Stop doing CRISPR. Start using CRISPR. Synthego have optimized CRISPR. You focus on discoveries. Synthego’s Engineered Cells are powered by the Eclipse™ Platform.
Knockout iPS Cells
Leverage high editing efficiencies without sacrificing quality. Confidently perform gene function analyses or precise target validation, enabled by gene knockouts from Synthego’s automated CRISPR workflow.
What You Can Do
Access Unprecedented CRISPR Knockout Efficiency in iPSCs Without Sacrificing Quality
Engineered Knockout iPS Cells are the one-stop-solution to access reliable and accurate gene disruption in induced pluripotent stem cells (iPSCs) for your gene function or gene-disease linkage studies. Synthego’s robust CRISPR editing process delivers consistently high knockout efficiency (>95%) to even near-complete, functional knockout even prior to clonal selection. Using high-quality, synthetic non-integrating reagents, Synthego’s proprietary, automated process preserves cell viability and pluripotency, eliminating concern that your cells are carrying artifacts that may negatively impact experimental integrity.
Engineered Knockout iPS Cells are available as clones (derived from single cells and are 100% knockout guaranteed), or pools (edited cells that have not undergone single-cell sorting).
Leverage the full potential of precise Knock-in iPS Cells. Confidently perform protein localization studies or utilize isogenic neuronal lines enabled by knock-in editing from Synthego’s automated CRISPR workflow.
Precise CRISPR Knock-Ins While Maintaining the Quality of Your iPSCs
When your neuroscience, cardiovascular or regenerative medicine research calls for an iPSC (induced pluripotent stem cell) edit, let Synthego handle the editing, so you can focus on assay development, differentiation, and/or other downstream applications. Synthego utilizes a robust, automated platform for CRISPR editing iPSCs that achieves high editing efficiencies while maintaining quality to ensure pluripotency. Their reliable process puts your mind at ease when differentiating your CRISPR-edited iPSCs into your final cell type.
To enable your discoveries, Synthego offers knock-ins that generate single nucleotide variants (SNVs), tags, and <100 bp insertions, in homozygous or heterozygous states and clone or pool formats.
What You Can Do
Access CRISPR Cell Lines Without Sacrificing Time.
Generating genetically modified CRISPR knockout cells yourself is a complex process that can take several months to complete – with no guarantee of success. Let Synthego help accelerate your research by creating your knockout clonal cell lines, allowing you to focus on your discoveries.
Synthego’s CRISPR Knockout Cell Clones deliver your desired gene knockout, 100% sequence verified in hundreds of human cell lines, in as few as 10 weeks.
You now have full access to the latest CRISPR technology in your lab.
Accelerate Your Discoveries with CRISPR Knockout Cells.
Synthego’s Knockout Cell Clones provide a fast and easy path to fully realizing CRISPR’s potential. Achieve the results you need to advance your research without investing the considerable time and effort required to generate CRISPR cell lines in your lab.
Your CRISPR Knockout Cells. Guaranteed.
CRISPR-Cas9 is a powerful research tool, but learning and perfecting this revolutionary technology takes time.
Every order contains two vials of a knockout pool—a mixed population of edited cells—two vials of unedited cells, and a QC report. The Knockout Cell Pool arrives with guaranteed 50% or better gene knockout so cells are ready to assay, or can be selected for clonal isolation.
Spend your time making discoveries, not optimizing CRISPR editing.
Each Knockout Cell Pool product undergoes Synthego’s rigorous cell editing process, which consists of sgRNA design, transfection optimization, gene editing, and sequencing validation. We take on the hard work of CRISPR editing, so you don’t have to.
All the benefits of CRISPR are one click away.