Entries by Harshita Sharma

Protein Cartridges

PRODUCTS

Protein Cartridges

Protein Cartridges

P2 Protein Cartridge Kit

  1. The cartridge analyzes protein sample size and purity with higher sensitivity and resolution.
  2. The analysis size range is 11~155kDa but the detection range is up to 600kDa.
  3. Qsep100 Advance is the recommended platform for detecting fluorescent-labeled protein sample.
  4. Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.

P2 Cartridge BiOptic

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    Quantification Kit

    PRODUCTS

    Quantitative Kit

    Quantitative Kit

    S2 Standard Quantitative Cartridge Kit

    1. The fragment sizes and relatively accurate quantitative results can be obtained simultaneously. Extra time and cost for quantitative analysis can be saved.
    2. S2 cartridge is for PCR products, small-sized DNA, and NGS quality control (Fragmentation and Library sample) analyses.
    3. The analysis time is about 3 minutes, and the best resolution is 4~10bp if the sample size is less than 500bp.
    4. Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
    5. The cartridge can be stored at 4~27°C and is valid for 6 months.

    Standard Quantitative Cartridge Kit BiOptic

    S1 High Resolution Quantitative Cartridge Kit

    1. The fragment sizes and relatively accurate quantitative results can be obtained simultaneously. Extra time and cost for quantitative analysis can be saved.
    2. Not only the total concentration but also the individual fragment concentration can be provided.
    3. The analysis time is about 3~5 minutes, and the best resolution is 1~4bp if the sample size is less than 500bp.
    4. Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
    5. The cartridge can be stored at 4~27°C and is valid for 6 months.

    High Resolution Quantitative Cartridge Kit BiOptic

    N1 High Sensitivity Quantitative Cartridge Kit

    1. The fragment sizes and relatively accurate quantitative results of low concentration DNA can be obtained simultaneously with individual fragment concentration provided.
    2. The applications include low concentration DNA fragments and cell-free DNA quality control.
    3. The analysis takes about 3 minutes with a recommended size range up to around 5,000bp and a detection limit of about 10 pg/μl.
    4. Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.
    5. The cartridge can be stored at 4~27°C and is valid for 4 months.

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    BiOptic Consumables Portfolio

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      DNA Cartridges

      PRODUCTS

      DNA Cartridges

      DNA Cartridges

      S2 Standard Cartridge Kit

      1. S2 cartridge is for PCR products, small-sized DNA, and NGS quality control (Fragmentation and Library sample) analyses.
      2. The analysis time is 2~3 minutes and the best resolution is 4~10bp if the sample size is less than 500bp.
      3. It has a recommended size range up to around 5,000bp and a detection limit of about 0.1 ng/μl in low concentration.
      4. Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
      5. The cartridge can be stored at 4~27°C and is valid for 6 months.

      S2 Cartridge (Standard Cartridge) BiOptic

      S1 High Resolution Cartridge Kit

      1. The analysis time is 2~5 minutes and the best resolution is 1~4bp if the sample size is less than 500bp.
      2. It provides high resolution result with multiple methods from low to high voltage (2~10kV) for user to choose from.
      3. It has a recommended analysis range up to around 5,000bp and a detection limit of about 0.1 ng/μl in low concentration.
      4. Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
      5. The cartridge can be stored at 4~27°C and is valid for 6 months.

      S1 Cartridge BiOptic

      S3 Kilobase Cartridge Kit

      1. S3 cartridge is for large-sized DNA analysis.
      2. It has a recommended 5~165kb size range and is ideal for quality control of second and third generation sequencing.
      3. The system provides DNA Quality Number (DQN) for gDNA integrity reference.
      4. Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
      5. The cartridge can be stored at 4~27°C and is valid for 6 months.

      S3 Cartridge BiOptic

      F3 Fast Cartridge Kit

      1. The analysis time is 90 seconds and can be applied to PCR product analysis.
      2. It has a recommended analysis range up to around 5,000bp for DNA.
      3. It runs on Qsep100 and Qsep400 only.
      4. Each cartridge can analyze 300 runs for single-channel cartridge or 1200 runs for 4-channel cartridge.
      5. The cartridge can be stored at 4~27°C and is valid for 4 months.

      F3 Cartridge BiOptic

      N1 High Sensitivity Cartridge Kit

      1. The sample concentration for analysis has a detection limit of about 5 pg/μl (or 1 pg/μl if dissolved in ddH2O) and the analysis time is about 3 minutes.
      2. It can be used for analysis of low concentration DNA fragment and quality control of cell-free DNA.
      3. It has a recommended analysis range up to around 5,000bp for DNA.
      4. Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.
      5. The cartridge can be stored at 4~27°C and is valid for 4 months.

      N1 Cartridge BiOptic

      N3 High Sensitivity Kilobase Cartridge Kit

      1. N3 cartridge is for low concentration large-sized DNA analysis.
      2. It has a recommended 5~165kb size range and is ideal for quality control of second and third generation sequencing.
      3. The system provides DNA Quality Number (DQN) for gDNA integrity reference.
      4. Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
      5. The cartridge can be stored at 4~27°C and is valid for 4 months.

      N3 Cartridge BiOptic

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        Qsep1-Plus

        PRODUCTS

        Qsep1-Plus

        Qsep1-Plus



        Smallest/portable-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.



        Qsep1-Plus is ideal for small laboratories with low throughput (1~15 samples) needs.



        The system supports Wi-Fi and cable connections, breaking the barriers of space.



        10+ types of cartridges can be easily exchanged between various applications.



        The provided quantitative method delivers fragment size and concentration information in one run.

        Qsep1-Plus has the highest specification product among all portable automated Bio-Fragment Analyzers. Advantages of capillary electrophoresis are high resolution (1~4bp if less than 500bp), high sensitivity (5pg/μl) and significantly faster preparation and analysis time. Besides analyzing fragment sizes and concentrations, it is also suitable for quality control of next-generation sequencing (NGS).

        Qsep1-Plus is equipped with completed hardware and software and has fully functional remote access via cable/Wi-Fi. The system provides various kinds of applications such as RNA quality control with RNA Quality Number (RQN) provided, auto-distribution of NGS QC and quality control of gDNA with DNA Quality Number (DQN) provided. Qsep1-Plus is a top choice for modern small or medium-sized laboratory.

        Qsep series can not only replace the complicated and time-consuming gel preparation and analysis procedure, but increase the accuracy of analysis, elevate efficiency and reproducibility, and reduce the human error and costs.

        Qsep1-plus BiOptic

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        BiOptic Instruments Portfolio

        Qsep100

        Qsep1

        Qsep400

        Qsep1+

        Qsep100 Advance

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          Qsep400

          PRODUCTS

          Qsep400

          Qsep400



          4-channel Bio-Fragment Analyzer designed for medium and large-sized labs, offering higher throughput and faster analysis.



          Qsep400 features an integrated PC and touchscreen for user-friendly operation.



          Capable of analyzing DNA, RNA, or protein with a 4~96 sample capacity.



          Quantitative method provides comprehensive fragment size and concentration data in a single run.

          Qsep400 is a high-throughput automated Bio-Fragment Analyzer. It is the highest specification product of Qsep series and can analyze hundreds of samples in one day. It supports various types of applications, including DNA, RNA and protein fragment analyses and high-voltage fast analysis. Advantages of capillary electrophoresis are high resolution (1~4bp if less than 500bp), high sensitivity (5pg/μl) and significantly faster preparation and analysis time. Besides analyzing the fragment sizes and concentrations, it is also a tool for quality control, and is best for NGS facilities and research centers.

          Qsep400 is equipped with an integrated PC and touchscreen and can be directly controlled and analyzed. The system provides applications such as RNA quality control with RNA Quality Number (RQN) provided, auto-distribution of NGS QC and quality control of gDNA with DNA Quality Number (DQN) provided. Qsep400 is an independent and highly-efficient instrument.

          Qsep series can not only replace the complicated and time-consuming gel preparation and analysis procedure, but increase the accuracy of analysis, elevate efficiency and reproducibility, and reduce the human error and costs.

           

          Qsep400 BiOptic

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            Qsep100

            PRODUCTS

            Qsep100

            Qsep100



            Standard-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.



            Ideal for small to medium-sized labs with 1~96 sample capacity.



            Easily exchangeable cartridges for versatile applications.



            Provides quantitative data on fragment size and concentration in a single run.

            Efficient Bio-Fragment Analysis with Qsep100

            The Qsep100, a standard-sized automated Bio-Fragment Analyzer, represents the classic model in the Qsep series. Boasting a single-channel design, it can seamlessly process 1 to 96 samples, making it an ideal choice for small and medium-sized laboratories. This high sample flexibility extends to various applications, including DNA, RNA, and protein fragment analyses, as well as high-voltage fast analysis.

            Versatility for Various Applications

            The Qsep100 supports a range of applications, offering RNA quality control with the provision of RNA Quality Number (RQN), automated distribution of NGS QC, and quality control of genomic DNA (gDNA) with the availability of DNA Quality Number (DQN). Particularly, it stands out as a top choice for Next-Generation Sequencing Quality Control (NGS QC).

            Streamlining Processes and Enhancing Accuracy

            The Qsep series, including the Qsep100, eliminates the need for intricate and time-consuming gel preparation and analysis procedures. This not only increases the accuracy of analysis but also elevates overall efficiency and reproducibility while reducing human errors and costs. Invest in Qsep100 for a seamless, reliable, and efficient bio-fragment analysis experience.

            Qsep100 BiOptic

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            BiOptic Instruments Portfolio

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              Qsep1

              PRODUCTS

              Qsep1

              Qsep1



              Smallest/portable-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.



              Ideal for small laboratories with low throughput needs (1~8 samples).



              Supports Wi-Fi and cable connections, enhancing spatial flexibility.



              Easy exchange of 10+ cartridges between various applications.



              Quantitative method provides fragment size and concentration info in a single run.

              Qsep1 is an automated Bio-Fragment Analyzer for DNA, RNA and protein fragments. Advantages of capillary electrophoresis are high resolution (1~4bp if less than 500bp), high sensitivity (5pg/μl) and significantly faster preparation and analysis time. Besides analyzing fragment sizes and concentrations, it is also suitable for quality control of next-generation sequencing (NGS).

              Qsep1 is equipped with completed hardware and software and has fully functional remote access via cable/Wi-Fi. The system provides various kinds of applications such as RNA quality control with RNA Quality Number (RQN) provided, auto-distribution of NGS QC and quality control of gDNA with DNA Quality Number (DQN) provided. Qsep1 is a top choice for modern small laboratory.

              Qsep series can not only replace the complicated and time-consuming gel preparation and analysis procedure, but increase the accuracy of analysis, elevate efficiency and reproducibility, and reduce the human error and costs.

              Qsep1 BiOptic

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              BiOptic Instruments Portfolio

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                Viral Controls

                PRODUCTS

                Synthetic Viral Controls

                Synthetic Viral Controls

                Trusted Controls for Diverse Applications

                In the wake of the global demand for diagnostic tests amid the Coronavirus pandemic, laboratories worldwide seek reliable tools for detecting SARS-CoV-2 and Respiratory viruses across various sample types. Our controls offer a trusted solution to address the expanding need for testing, ensuring accuracy and safety in a wide range of applications.

                Ensuring Reproducible, High-Quality Results

                Positive controls play a pivotal role in maintaining quality standards for diagnostic assays, spanning from development to day-to-day testing. These controls facilitate the verification and validation of diagnostic tests, supporting both next-generation sequencing (NGS) and reverse transcription polymerase chain reaction (RT-PCR) assays, ensuring reproducibility and reliability.

                Safe and Effective Alternatives to “Live Virus”

                Concerns regarding safety and security associated with controls based on viral nucleic acids extracted from infected patients or live virus cultures led us to develop synthetic controls through gene synthesis. These alternatives offer a safe and effective solution, allowing broader access to diverse strains while mitigating potential risks.

                Flexible Formulations for Varied Needs

                Tailor your approach with our flexible control formulations—Standard, Assay Ready, or Encapsulated. Whether in a frozen liquid, dried pellet, or encapsulated dried pellet form, our controls provide options for shipping, storage, and stability, meeting the unique requirements of your applications. Ambient shipping reduces costs and enhances accessibility for researchers globally, making our controls a reliable choice in the dynamic landscape of diagnostic testing.

                RESPIRATORY VIRUS CONTROLS

                Comprehensive Controls for Respiratory Virus Research

                Twist’s Synthetic Respiratory Virus Controls encompass a wide spectrum of RNA and DNA viruses crucial for respiratory disease studies. Aligned with the Twist Respiratory Virus Research Panel (PN 103067), these controls seamlessly integrate into Twist Fixed Panel NGS workflows, as well as RT-PCR or qPCR experiments designed by users.

                Navigating the Viral Landscape

                Refer to the taxonomic tree in the accompanying figure for a visual representation of the viruses covered by Twist Respiratory Virus Controls. The table provides GenBank IDs, virus types, and lengths for each control, facilitating an in-depth understanding of the viral landscape. Custom synthesis options are also available—connect with your local sales representative for additional details.

                Simplify Your Research Journey

                For further information or to make a purchase, contact your local sales representative or conveniently “Buy Now.” Twist’s Synthetic Respiratory Virus Controls offer a robust foundation for respiratory virus research, enhancing the precision and reliability of your experiments.

                SARS-COV-2 CONTROLS

                SARS-COV-2 CONTROLS

                Elevating Quality Control with Twist Synthetic RNA Controls for SARS-CoV-2

                Twist Bioscience offers synthetic RNA controls designed for diverse viral genomes, including SARS-CoV-2. With six non-overlapping 5 kb fragments transcribed into ssRNA, these controls provide over 99.9% genome coverage. Available in standard, Assay Ready, and Encapsulated Formats, they cater to various needs with concentrations tailored for flexibility.

                Unique Stability in Encapsulated Controls

                Twist’s Encapsulated Controls, sealed in a metal capsule around a desiccated pellet, ensure enhanced stability. With room temperature shipping and a five-year shelf life, these controls provide cost-effective and globally accessible solutions.

                Contribution to Multiplex Assay Development

                The Twist Assay Ready Synthetic SARS-CoV-2 RNA Control, developed with the US CDC, enables simultaneous testing for influenza A, B, and SARS-CoV-2. Originally designed for authorized laboratories, it is now available to customers outside the CDC.

                Best Practices and Regulatory Considerations

                For comprehensive guidance on storage and use of controls, refer to provided documents: Twist Assay Ready Synthetic Controls Storage and Use Document and Twist Sars-CoV-2 Encapsulated RNA Control Storage and Handling Guide.

                Note: This product is authorized for emergency use by the FDA under an EUA for the detection of SARS-CoV-2 nucleic acid. The emergency use is limited to circumstances justifying the authorization.

                SARS-COV-2 CONTROLS

                MONKEYPOX CONTROLS

                Twist Synthetic hMPXV Controls: Precision for Targeted Research

                Twist’s Synthetic Human Monkeypox Virus (hMPXV) Controls, representing CB and WA clades, cover over 80% of the viral genome. Validated for custom assays and compatible with CDC-recommended PCR procedures, these controls, in two variants, offer precise tiling of the genome at 900bp intervals. With concentrations at approximately 100,000 copies/uL, they provide accuracy and reproducibility. Contact your local sales representative for more information.

                Note: The Twist Synthetic hMPXV Controls are not ISO-13485 certified.

                Monkeypox control by Twist Bioscience

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                Synthetic Controls Portfolio

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                  cfDNA Pan-cancer Reference Standards

                  Twist cfDNA Pan-Cancer Reference Standard v2

                  The Twist cfDNA Pan-Cancer Reference Standard v2 is a meticulously engineered tool tailored for genomics professionals developing and validating NGS-based liquid biopsy assays. This reference standard provides a reliable and reproducible resource for detecting clinically relevant variants, enabling researchers to confidently evaluate assay performance at every stage. By integrating a wild-type (WT) cell-free DNA (cfDNA) background with synthetic oligonucleotides carrying mutant alleles, the material delivers exceptional precision and sensitivity.

                  Researchers can leverage this standard to define critical analytical parameters, including the Limit of Detection (LoD) and Limit of Blank (LoB), ensuring robust assay calibration and quality control. Ideal for both early-stage assay development and ongoing process monitoring, the Twist cfDNA Pan-Cancer Reference Standard v2 empowers genomics teams to accelerate liquid biopsy innovation while maintaining rigorous accuracy and reproducibility.

                  But... Why These Panels?



                  Comprehensive Detection of Cancer Variants

                  458 unique naturally occurring cancer variants

                  132 clinically relevant variants

                  Covers 84 different genes involved in cancer



                  Better Design of Background
                  DNA

                  Background DNA derived from human cfDNA samples

                  DNA size profile and post-sequencing profile mimic native cfDNA



                  Designed for Precision and Flexibility

                  Seven individual VAF percentages to choose from

                  Digital Droplet PCR verification of VAF percentages

                  Convenient test set of all VAF percentages available

                  Download Product Sheet, Data Files & Detailed FAQs

                  Unlock instantly with few steps.


                    Data To Back This Up

                    Fragment Profile Comparison: Twist vs. Competitors

                    Twist cfDNA Pan-Cancer Reference Standard v2 closely mimics the fragment size distribution of native cfDNA, including distinct mononucleosomal and dinucleosomal peaks. When compared to competitor reference materials standardized for peak height, Twist’s standards provide a more biologically accurate representation of circulating cell-free DNA, supporting realistic assay development and reliable performance benchmarking.

                    Schematic of Synthetic Variant DNA Design

                    Twist’s synthetic variant DNA is engineered to tile across each genomic locus with extensive overlap, ensuring high coverage and diverse fragment representation. This design captures the variant in multiple positions relative to the DNA termini, providing realistic fragment diversity and enabling more accurate assay performance assessment.

                    Background Mutation Rate Comparison

                    Background mutation rate measures the occurrence of non-germline variants in duplex consensus reads from target-enriched wild-type samples. Analysis across Twist cfDNA Pan-Cancer Reference Standard v2, native cfDNA, competitors, and Twist v1 shows that v2 closely matches the low background error rate of native cfDNA. Its superior fidelity—lower than both v1 and competitor standards—is achieved through a high-precision production process, ensuring more reliable and accurate assay benchmarking.

                    INDEL Size Distribution

                    The Twist cfDNA Pan-Cancer Reference Standard v2 includes a wide range of insertion and deletion (INDEL) sizes, from deletions of 30 bp to insertions of 15 bp. Visualized as a histogram (bin width = 1), this distribution allows researchers to comprehensively evaluate INDEL detection performance across diverse fragment lengths. Single nucleotide variants (SNVs) are not included in this visualization, highlighting the standard’s focus on structural variant representation and assay sensitivity testing.

                    Variant Calling in Target Enrichment Workflows

                    Twist cfDNA Pan-Cancer Reference Standards deliver highly accurate variant detection across a range of variant allele frequencies (VAFs). Using a custom panel targeting 215 SNVs and sequencing to 80,000× raw coverage before UMI deduplication, the observed mean VAFs closely match the intended levels. This precision allows researchers to confidently benchmark and validate their NGS-based assays, ensuring reliable performance across the full spectrum of variant frequencies.

                    Related Products

                    Twist UMI Adapters

                    Detect low freqency variants from cfDNA with unique molecular IDs (UMIs).

                    MRD Rapid 500 Panels

                    A scalable target enrichment solution for monitoring minimal residual disease.

                    Custom Panels

                    User-designed target enrichment panels for targeted NGS.

                    Product SKUS

                    107576: Twist cfDNA Pan-Cancer Reference Standard v2 Set, 300ng kit

                    107577: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0% (WT), 3 ug

                    107578: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0.1%, 3 ug

                    107579: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0.25%, 3 ug

                    107580: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0.5%, 3 ug

                    107581: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 1%, 3 ug

                    107582: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 2%, 3 ug

                    107583: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 5%, 3 ug

                    107584: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0%, 600ng

                    107585: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0.1%, 600ng

                    107586: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0.25%,600ng

                    107587: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 0.5%, 600ng

                    107588: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 1%, 600ng

                    107589: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 2%, 600ng

                    107590: Twist cfDNA Pan-Cancer Reference Standard v2 VAF 5%, 600ng

                    *Kit includes 7 VAFs individually: 0% (WT), 0.1%, 0.25%, 0.5%, 1%, 2%, 5% at 300ng each tube

                    *For research use only. Not for use in any diagnostic or clinical procedures.

                    Chris Wicky

                    Clinical Genomics Manager - ANZ
                    & Country Manager - NZ

                    For support integrating the Twist cfDNA Pan-Cancer Reference Standards into your workflows, Decode Science offers personalized guidance and local expertise to help you maximize assay performance and streamline your liquid biopsy development.

                    Twist Portfolio

                    Twist NGS

                    NGS

                    Raise confidence in variant detection with superior target enrichment solutions

                    Twist Oligo Pools

                    Oligo Pools

                    Precision, uniformity, and flexibility for results you can trust

                    Synthetic Controls

                    Synthetic RNA and DNA standards for assay development

                    Twist Libraries

                    Libraries

                    Identify more hits and streamline screening with Twist's precise Variant Libraries

                    Twist Genes

                    Genes

                    DNA Your Way: think bigger, expand your scope, and accelerate discovery in genes

                    Twist Antibody

                    Antibody

                    Robust solutions for Antibody Discovery and Development by Twist Bioscience

                    Synthetic Controls Portfolio

                    Custom Panels

                    PRODUCTS

                    NGS Custom Panels

                    Twist Custom NGS Target Enrichment Panels -
                    Precision Panels, Distributed by Decode Science

                    Twist Bioscience’s custom target enrichment panels are designed using a silicon-based DNA synthesis platform that produces highly accurate, reliable probes for next-generation sequencing (NGS). These panels can be tailored to suit a wide variety of applications, from small and highly focused panels targeting specific regions to large and complex designs that span broad genomic areas, making them suitable for almost any sequencing project. The combination of advanced design algorithms, proprietary synthesis processes, and a streamlined production pipeline ensures that each panel delivers uniform coverage, reduced off-target effects, and consistent, high-quality performance across sequencing platforms.

                    Another advantage of Twist’s approach is the flexibility it provides. Researchers can expand existing panels, update or enhance them with new content, or even combine multiple designs into blended panels to support evolving project needs. Turnaround times are fast, and the resulting panels are built to maintain accuracy and reproducibility, ensuring dependable results even in demanding research environments.



                    Exceptional, Reliable Performance

                    Twist’s double-stranded DNA probes undergo NGS-based quality control to ensure balanced representation and minimise dropout



                    Panel Blending

                    Easily combine two or more panels into a single design, either in your own lab or through Twist’s streamlined blending service.



                    Simple Design

                    Submit specifications online and benefit from Twist’s advanced design algorithms that optimize every panel for accuracy and efficiency.



                    Scalable Panels

                    From 100 probes to one million, Twist custom panels can be tailored to projects of any size while maintaining consistency and precision.

                    Chris Wicky

                    Clinical Genomics Manager - ANZ & Country Manager - NZ

                    As the official distributor for Twist Bioscience in Australia and New Zealand, Decode Science makes accessing these panels straightforward. Our role is to connect your lab with Twist’s advanced technologies, ensuring you get the right custom panel solution for your sequencing projects—delivered locally with support when you need it.

                    Nucleic Acid Panel Designs

                    DNA

                    Twist Bioscience’s custom DNA target enrichment panels provide advanced solutions for a variety of sequencing applications. Using proprietary strategies such as probe shifter technology, these panels deliver precise, consistent coverage and high-performance results tailored to specific biological targets.

                    RNA

                    Twist Bioscience’s RNA custom target enrichment panels are designed to capture and enrich cDNA libraries for next-generation sequencing (NGS). Using innovative strategies such as exon-aware probe placement, these panels provide precise, high-performance coverage to maximize transcriptional insights from your RNA sequencing experiments.

                    Methylation

                    Twist Bioscience’s methylation target enrichment panels are designed to capture libraries prepared to reveal DNA methylation patterns. Using a unique design approach with four probe species per target—fully methylated and unmethylated, sense and antisense—these panels deliver uniform coverage while preserving accurate methylation signatures for reliable NGS analysis.

                    Featured Resources

                    Custom NGS Assay

                    How analysis of blood-derived cfDNA enables minimally-invasive molecular...

                    Product Sheet

                    Design a Twist Custom Panel in minutes using a list of gene names or a ...

                    Exploring Redwood Genomes

                    Watch the interview where Twist chatted with Alexandra “Sasha” Nikolaeva (SN) ....

                    FAQs

                    What is the standard probe length in a custom panel?

                    Custom panels typically use probes that are 120 base pairs (bp) long. Twist also offers alternative lengths—such as 80 bp or 100 bp—depending on your experimental needs, but all probes within a single panel are uniform in length.

                    Can target enrichment panels be customized for gene fusions and SNPs?

                    Yes. Twist custom panels can be designed for a variety of targets, including gene fusions, single nucleotide polymorphisms (SNPs), viruses, microsatellite instabilities (MSIs), structural variants, copy number variants (CNVs), and insertion/deletion events (InDels).

                    Can Twist design panels for targeted methylation (bisulfite) sequencing?

                    Yes. Twist offers custom panels specifically for targeted methylation sequencing, optimized to capture methylation patterns with high accuracy.

                    Are Twist target enrichment probes double-stranded?

                    Yes, all Twist target enrichment probes are double-stranded DNA, ensuring stable hybridization and reliable performance.

                    How is the quality of Twist probes ensured?

                    Twist performs NGS-based quality control by sequencing the probes to verify their representation within the pool, ensuring consistent and uniform performance across the panel.

                    Ready To Order?

                    As the official distributor for Twist Bioscience in Australia and New Zealand, Decode Science makes accessing these panels straightforward. Our role is to connect your lab with Twist’s advanced technologies, ensuring you get the right custom panel solution for your sequencing projects—delivered locally with support when you need it.

                    NGS Portfolio