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MGI is a global life science company offering lab automation and a comprehensive NGS sequencing product portfolio. MGI takes pride in its ability to develop and manufacture a full spectrum of instruments, ranging from low to extra-high throughput genetic sequencers, accelerating scientific breakthroughs for our scientists.
DNBSEQ™ technology combines the low error accumulation of DNA Nanoballs (DNB) with the high signal density of regular array chips, resulting in significantly improved detection accuracy, especially for Whole Genome Sequencing (WGS) and Whole Exome Sequencing (WES).
The DNBSEQ™ process includes efficient DNA single strand circularization and DNB making, using rolling circle replication (RCR). RCR reduces error introduced during amplification, leading to greatly improved sequencing accuracy.
The patterned array and DNB loading ensure high sequencing accuracy, optimal chip utilization, and efficient reagent usage. This results in high throughput and cost-effective sequencing.
The Combinatorial Probe-Anchor Synthesis (cPAS) technology incorporated in DNBSEQ™ allows for high-speed, high-accuracy base calling, significantly improving the sequencing reaction time.
MGI's proprietary Sub-pixel Registration algorithm and GPU accelerated algorithm enable image intensity extraction at the sub-pixel level, greatly improving base call accuracy and dramatically increasing data processing speed.
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