Simoa Dry Blood Extraction Kit

January 8, 2026/in Partners, Quanterix/by Harshita Sharma

Huber, H., Montoliu-Gaya, L., Brum, W.S. et al. A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology. Nat Med (2026). https://doi.org/10.1038/s41591-025-04080-0

Simoa Dry Blood Extraction Kit

The Simoa Dry Blood Extraction Kit is a validated, device-agnostic solution for extracting analytes from dried plasma and dried blood spot (DPS/DBS) samples for use with Simoa® assays. It enables consistent, reproducible recovery of low-abundance biomarkers while maintaining the femtogram-level sensitivity required for clinical and translational research.

Designed to support decentralized and remote sample collection, the kit simplifies pre-analytical workflows without compromising data quality. It is well suited for longitudinal studies, multi-site trials, and settings where traditional venous sampling and cold-chain logistics are impractical.

Key Features of the Simoa Dry Blood Extraction Kit

Clinical Evidence: DROP-AD Study (Nature Medicine)

Hanna Huber
Nutrition Scientist // Ph.D // Postdoctoral researcher @DZNE Bonn & University of Gothenburg

The Simoa Dry Blood Extraction Kit workflow is supported by evidence from the DROP-AD study, published in Nature Medicine, demonstrating that capillary dried blood samples can be used to reliably quantify key Alzheimer’s disease biomarkers.

The multi-centre European study showed strong concordance between capillary dried blood and conventional venous plasma measurements for:

p-Tau217 – strong correlation across multiple sites
GFAP and NfL – reliable quantification with high plasma concordance

The approach demonstrated good diagnostic accuracy for identifying CSF-confirmed Alzheimer’s pathology and high reproducibility with self-collected samples, supporting decentralized and remote study designs.

Importantly, the study confirms the feasibility of this approach in high-risk and underrepresented populations, including individuals with Down syndrome, and eliminates the need for venipuncture, centrifugation, and cold-chain logistics.

This workflow is intended for research use only and is not designed for clinical diagnosis or clinical decision-making.

Instant Download Simoa Dry Blood Extraction Kit Tech Note

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Designed for Real-World Clinical and Research Workflows

The Simoa Dry Blood Extraction Kit is designed to support high-sensitivity biomarker analysis in settings where traditional venous sampling and cold-chain logistics are limiting.

For academic and translational neuroscience teams conducting large cohort or longitudinal studies, the kit provides a standardized method for extracting biomarkers from small-volume, remotely collected samples, reducing pre-analytical variability and improving inter-site comparability.

In pharmaceutical and biotechnology research, the workflow supports early-phase and decentralized study designs where sample volume is limited but analytical sensitivity is critical.

For public health and global research settings, the kit enables reliable laboratory-grade biomarker analysis from capillary dried blood samples, supporting studies in low-resource or geographically distributed populations.

Applications and Intended Use

The Simoa Dry Blood Extraction Kit is intended for the extraction of analytes from capillary-derived dried blood and plasma collection devices to support detection of low-abundance biomarkers using Simoa® assay kits.

For research use only.

Kit Contents

Each kit includes Quanterix extraction buffer and two precipitation plates.

As the official distributor of Quanterix in Australia and New Zealand, Decode Science is providing local access to Simoa® platforms, assays, and workflow solutions with region-based technical and application support.

Proteomics in Transition: From Discovery to Diagnostic Relevance Whitepaper

November 24, 2025/in Quanterix/by Harshita Sharma

Proteomics in Transition: From Discovery to Diagnostic Relevance Whitepaper

For years, discovery proteomics uncovered hundreds of candidate biomarkers — but most stalled before reaching the clinic. New digital platforms change that: they deliver femtogram-level sensitivity, reproducible quantification across sites, and the analytical rigor required for regulatory and clinical use.

Why this matters
Proteins reflect real-time biology. That means faster detection, better trial enrollment, and clearer measures of therapeutic effect. Whether you’re developing a diagnostic, designing an adaptive trial, or building a multi-omics model, the right proteomic data reduces guesswork and accelerates decisions.

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As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

BCR Sequencing of 1 Million Healthy and Diseased Samples in a Single Experiment

November 24, 2025/in Parse/by Harshita Sharma

BCR Sequencing of 1 Million Healthy and Diseased Samples in a Single Experiment

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Key Takeaways

Profiled 1 million human B cells in a single experiment
Detected 900,000+ unique paired clonotypes across Type 1 Diabetes, Multiple Sclerosis, Rheumatoid Arthritis, Crohn’s, Celiac, and healthy donors
Achieved sensitive detection of CDR3 regions, clonotypes, and full-length sequences at scale

Evercode BCR uncovered over 900,000 unique paired clonotypes across 24 samples in a single experiment. Negatively selected B cells from 12 healthy donors were purchased, while pan B cells were isolated from 12 autoimmune-diseased human PBMCs and fixed using the Evercode Cell Fixation Kit v3 to preserve cell structure and protect RNA integrity. Fixed samples were stored at -80°C until all were ready for combined processing with the Evercode BCR Mega Kit. Whole transcriptome and BCR-specific libraries were sequenced on the Illumina Novaseq X, and data were analyzed using Parse Biosciences’ Analysis Pipeline v1.3.0. Clustering with Seurat 5.0 showed that the majority of cells corresponded to major B cell subtypes, as illustrated in the UMAP below (Figure 1).

The assay demonstrated high sensitivity, detecting paired heavy and light chains in up to 89% of cells (Figure 2).

Downloads

As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

MosaiX High-Complexity Library Prep Kit – Early Access Promotion

November 24, 2025/in SeqWell/by Harshita Sharma

MosaiX High-Complexity Library Prep Kit ,
– Early Access Promotion

Be among the first to experience the newest in high-complexity library prep technology.

SeqWell has just launched the MosaiX High-Complexity Library Prep Kit, unveiled at ASHG, and we’re offering a limited-time early-access promotion for researchers in AU & NZ.

5/5

Early-Access Offer Includes:

How to Qualify?

CNV Backbone Spike-in Panels

November 19, 2025/in NGS, Partners, Twist/by Harshita Sharma

Stronger CNV Detection — Without Changing Your Exome Workflow.

Large copy number variations can be easy to miss when exome sequencing focuses on exonic regions – leading to blind spots, repeat testing, and extra time interpreting unclear data. By spiking in Twist’s CNV Backbone Panels, you give your exome run the evenly spaced genomic coverage it needs to reliably surface clinically relevant CNVs — especially the ones standard exomes struggle with.

Available in 100 kb, 50 kb, and 25 kb resolutions, the CNV Backbone Panels strengthen your detection sensitivity while keeping your workflow identical. Blend it into your existing exome panel, follow your standard Twist enrichment protocol, and immediately get more confident CNV calls backed by consistent probe tiling across intergenic regions.

But... Why These Panels?

Download Poster on utilization of these panels with exome for cytogenetic research

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Why It Matters to You

Reliable CNV detection isn’t just a technical metric—it directly impacts research outcomes, diagnostic accuracy, and patient care. Standard exome sequencing often misses CNVs due to uneven probe coverage, creating blind spots in your analysis. Twist CNV Backbone Spike-in Panels bridge those gaps, ensuring that even subtle copy number changes are identified, so you can make confident, data-driven decisions.

For labs and clinicians, this means fewer follow-up tests, reduced time spent troubleshooting ambiguous results, and a smoother workflow. You can trust that your exome sequencing captures the variations that truly matter, whether for rare disease research, clinical diagnostics, or high-throughput screening.

Moreover, the ability to choose between 25 kb, 50 kb, or 100 kb resolution gives you control over sensitivity and throughput, aligning with your project goals and patient population needs. Evidence-based validation demonstrates improved detection of CNVs—including those smaller than 50 kb—so your results aren’t just comprehensive, they’re actionable.

By integrating these panels into your existing workflow, you enhance not only the quality of your data but also the efficiency of your lab operations, freeing time and resources for deeper analysis and patient-focused outcomes.

Select the CNV Resolution You Need

Table 1. Example data of Twist CNV Backbone Spike-in Panels. A highly characterized sample set known to contain CNVs (1) and a baseline set of 12 healthy individuals were sequenced with 2×150 reads on an Illumina NovaSeq 6000. The average number of SNVs, INDELs, and CNVs called and sequencing depth at each probe density was determined for each panel when spiked into Twist Exome 2.0 plus Comprehensive Spike-in. CNV calling was performed with a commercially available software solution (2)

(1) Coriell Institute’s CNVPANEL01 – Human CNV Reference Panel.
(2) eVai Platform (secondary workflow), enGenome Software.

A CRE.AI.TIVE application of AI: Engineering a more resilient global food supply

November 17, 2025/in Twist/by Harshita Sharma

A CRE.AI.TIVE application of AI: Engineering a more resilient global food supply

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Phytoform Labs harnessed its AI-powered CRE.AI.TIVE platform to develop climate-resilient crops, with a focus on drought-tolerant tomatoes. By rapidly exploring millions of potential sequence edits, the platform identified 2,000 high-potential candidates for wet-lab validation.

To overcome the challenge of synthesizing complex, AT-rich sequences with homopolymers, the team partnered with Twist Bioscience. Twist’s high-fidelity oligos ensured accurate transfer of AI-designed sequences to the lab, enabling efficient MPRA screening in tomato protoplasts.

This AI-guided workflow validated predictions while streamlining experiments—reducing waste, saving resources, and ensuring only the most promising variants progressed to in vivo testing.

Case Study Highlights

AI-driven design of millions of sequence variants
Efficient identification of high-impact edits, conserving time and resources
Ensuring fidelity of AI-generated oligos for complex plant sequences
Insights on impact and future directions

As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

Modified LongPlex™ Protocol (LongPlex XL)

November 17, 2025/in SeqWell/by Harshita Sharma

Modified LongPlex™ Protocol (LongPlex XL)

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This technical note outlines an alternative workflow for generating 10–15 kb HiFi reads from high-quality genomic DNA using the LongPlex Long Fragment Multiplexing Kit. In this approach, LongPlex is used to fragment and barcode samples, and PacBio’s Short Read Eliminator (SRE) is applied to size-select fragments >10 kb before SMRTbell® library preparation.

LongPlex uses plate-based transposase tagmentation for multiplexed fragmentation and barcoding, removing the need for mechanical shearing and allowing barcoded samples to be pooled before SMRTbell prep. This simplifies the workflow, increases throughput, and lowers library prep costs.

The standard LongPlex protocol generates 6–9 kb HiFi reads from high- to medium-quality DNA—ideal for microbial and other small-genome projects. However, users working with higher-quality DNA may want longer HiFi reads to maximize gigabase yield on PacBio systems.

This modified workflow is only suitable for high-quality DNA (Femto Pulse GQN30kb ≥7). Using degraded DNA will result in substantial sample loss during SRE size selection.

As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

Site Directed Mutagenesis

November 17, 2025/in Partners, Synbio Genes, Twist/by Harshita Sharma

Mutants Synthesized. Mutagenesis Simplified.

Make Site-Directed Mutagenesis precise, simple, and affordable with Twist’s Mutagenesis by Synthesis. Traditional site-directed mutagenesis can be time consuming and imprecise. Site directed mutagenesis through synthesis eliminates these complexities, providing you with precisely engineered sequences tailored to your exact specifications. From protein engineering to functional genomics, incorporate precision synthesis of mutants into your workflow and focus on achieving your research goals

Why it matters to you:

Precision engineering –

site-directed mutagenesis, custom DNA

Flexible design –

protein engineering, functional genomics

Fast turnaround –

Express Clonal Genes, rapid synthesis

Cost-effective –

affordable variants, scalable synthesis

How to Qualify

Product: Clonal Genes
Number of mutation per genes: No Limit
Mutation type: any number of point mutation,
deletions, and/or insertions*
Pricing: Discounts on every variant
(Please kindly contact your Decode Sales Rep for enquiry)

How it Works

Terms and Conditions
* This promo is only available to customers in the Asia Pacific region (excluding China and Japan). Pricing is subjected to changes.
* To enjoy the special service of site directed mutagenesis, please quote your previous order number or approach Decode Science support.
* Each mutation is defined as any combination of bases change within a 10 codon spread over the entire gene.
* Average turnaround time for Express Clonal Genes is 4 -7 business days. This time will vary based on complexity and length of the sequence. Orders placed outside of the US will incur additional delivery turnaround time. Turnaround time for Clonal Genes is subject to change based on customizations and complexity. Additional specification: 50ng – 2 ug.

Watch Successful Implementations

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Stronger, tighter, and faster: designing new protein functions

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Designing Enzymes for the Infinite Recycling and Upcycling of Plastic

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Screening Gene Libraries to Rapidly Identify Immune-recognised Virulence Genes.

As the authorized distributor of Twist Bioscience in Australia and New Zealand, Decode Science makes integrating Twist’s DNA synthesis solutions seamless. We connect your lab with high-throughput, high-fidelity Twist technology, enabling faster, more reliable genomic workflows—with local support and guidance every step of the way.

Twist Portfolio

Comparison of Evercode™ WT v3 and Chromium™ GEM-X Single Cell 3’ Kit v4 in Mouse Brain Nuclei

November 13, 2025/in Parse/by Harshita Sharma

Comparison of Evercode™ WT v3 and Chromium™ GEM-X Single Cell 3’ Kit v4 in Mouse Brain Nuclei

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Comparison Highlights

Evercode WT v3 delivers superior gene detection in head-to-head sensitivity tests.
Cell type proportions remain consistently represented.
Analysis of differential gene expression shows Evercode WT v3 identifies 2× more genes than competing methods.

Study Overview
Two embryonic mouse brains were sagittally dissected and flash-frozen by a third-party vendor.
One half from each brain was processed by a 10x Genomics certified provider for nuclei isolation and library preparation, while the other halves were processed by Parse Biosciences using their own workflow.
Sequencing was performed by a third-party, and data analysis was completed using each manufacturer’s respective pipeline.

As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

Optimized CRISPR/Cas9 Gene Knockout PDF

November 13, 2025/in EditCo, Partners/by Harshita Sharma

Accelerate knockout experiments with XDel’s next-generation CRISPR design.

EditCo Bio’s XDel technology eliminates the need for guide RNA pre-screening, using a coordinated multi-gRNA design that delivers consistently high on-target editing across immortalized, primary, and iPSC lines. Validated through 768 edited samples and 4,816 NGS libraries, XDel achieves robust knockout efficiency while minimizing off-target effects—saving time and improving reproducibility across diverse cell types.

Validated performance. Proven precision.
With a standardized amplicon sequencing QC workflow and high-throughput automation, XDel enables scalable, high-confidence Cas9-mediated editing for both pooled and single-cell clone analysis. Download the full guide to explore the data, workflows, and results behind EditCo Bio’s high-efficiency gene knockout strategy.

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As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

Device-agnostic compatibility

Standardized, semi-automated workflow

Preservation of analytical sensitivity

Direct compatibility with Simoa® assays

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Kit Contents

Julia Young

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Dr. Ebru Boslem

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Dr. Ebru Boslem

MosaiX High-Complexity Library Prep Kit , – Early Access Promotion

5/5

Chris Wicky

Early-Access Offer Includes:

How to Qualify?

Complete a short feedback survey by 31 December to access the early-bird discounted rate.

1. Fine-Tune CNV Resolution

2. Seamless Workflow Integration

3. Evidence-Based Performance

4. Flexible Panel Sizes

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Chris Wicky

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Chris Wicky

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Chris Wicky

Daina Elliott

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Dr. Ebru Boslem

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Hamza Hassan

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Special October Offer

FREE UMBRELLA

MosaiX High-Complexity Library Prep Kit ,
– Early Access Promotion