Arrayed gRNA Libraries

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PRODUCTS

Arrayed gRNA Libraries

Arrayed gRNA Libraries

Smarter, Faster, and More Efficient CRISPR Screening

Achieve unparalleled knockout efficiency with EditCo’s multi-guide CRISPR design. Our Arrayed CRISPR gRNA Libraries eliminate the inefficiencies of traditional loss-of-function screens, offering a reliable and ready-to-transfect solution. With up to three spatially coordinated sgRNAs per gene, our approach ensures higher knockout success, reduces false negatives, and eliminates the need for complex NGS data analysis. Designed for both human and mouse genes, our libraries provide fast delivery, robust quality control, and seamless Sanger sequencing analysis—so you can focus on results, not troubleshooting.

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Whole Genome CRISPR Libraries for Comprehensive Gene Editing

EditCo’s Whole Human and Whole Mouse Genome Libraries provide unmatched gene coverage with our multi-guide design, ensuring high editing efficiency across 20,000+ gene targets. Designed for seamless transfection, these libraries reduce false negatives and eliminate time-consuming preparation, making large-scale CRISPR screening easier than ever.

  • – Comprehensive Coverage: Target the entire human or mouse genome with high knockout efficiency.
  • – Ready-to-Use Libraries: Pre-plated and transfection-ready, minimizing preparation time.
  • – Enhanced Stability: Chemically modified sgRNAs resist degradation and prevent immune responses.
  • – Flexible Formats: Available in 96- or 384-well plates with multi-guide sgRNAs for reliable gene disruption.
Accelerate Target Discovery with Pathway Libraries

EditCo’s 30+ Pathway Libraries, including druggable targets, GPCRs, kinases, and immuno-oncology genes, provide a powerful tool for target identification studies. Designed with our multi-guide CRISPR strategy, these libraries ensure high knockout efficiency and fewer false negatives. Select libraries ship in as little as one week, helping you start your screen faster.

  • – Diverse Pathway Coverage: Includes key gene sets for drug discovery and functional studies.
  • – Fast Shipping: Select libraries ready to ship within a week.
  • – High-Efficiency Knockouts: Multi-guide sgRNAs deliver precise, predictable gene disruption.
  • – Ready-to-Use Format: Available in 96- or 384-well plates with modified sgRNAs for stability.
Available Gene Pathways
Optimal Knockout Efficiency for High-Throughput Screening

 

XDel technology delivers precise, high-efficiency knockouts by using a multi-guide RNA strategy that ensures consistent and reliable gene editing. Unlike traditional single-guide methods, XDel induces fragment deletions in early exons, maximizing on-target accuracy while minimizing variability and off-target effects.

  • Superior editing efficiency – Multi-guide design achieves higher and more consistent knockouts
  • Reduced off-target effects – XDel minimizes unintended edits compared to single-guide methods
  • Sustained knockout effects – Gene edits remain stable across multiple cell passages
  • High viability & protein depletion – Maintains cell health while ensuring effective functional knockouts

Achieve robust genotype and phenotype screening with XDel’s optimized CRISPR knockout technology.

XDel multiple gRNA creates fragment deletions

Image: XDel multiple gRNA creates fragment deletions

Image: XDel design includes up to 3 modified sgRNAs (grey bars) that target a single gene of interest

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Gene Knockout kits

Arrayed gRNA Libraries

Let’s Find You an Application That Helps Your Research

Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

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    1300 581 991

    Gene Knockout Kits

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    PRODUCTS

    Gene Knockout Kits

    national-cancer-institute-c-wqrSCjVf4-unsplash (2)

    EditCo Gene Knockout Kits: Reliable and Efficient CRISPR Solutions

    EditCo’s Gene Knockout Kit offers a simplified, highly efficient solution for generating human and mouse protein-coding gene knockouts. Unlike traditional CRISPR methods, which rely on a single guide RNA (gRNA) to create random indels, EditCo’s multi-guide approach ensures consistent and precise gene disruption. This method generates fragment deletions at the targeted loci, providing a more reliable and predictable knockout, ultimately enhancing experimental success. With fast delivery times (kits arrive in just 5 days), users can avoid the trial and error of guide screening and proceed quickly with their experiments. The process is streamlined further with an easy online ordering portal, which includes the option to purchase controls, SpCas9 nuclease, and Transfection Optimization kits to complement your knockout experiment. This solution guarantees high knockout efficiency, making gene editing faster and more reliable than ever before.

    Gene knockout cells
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    Human and Mouse Knockouts

    Guaranteed for human and mouse genes (excluding non-essential genes), ensuring high knockout efficiency.

    Multi-Guide sgRNA

    Chemically modified sgRNA resists degradation and prevents immune responses for reliable gene editing.

    Complete CRISPR Solution

    Optional add-ons like the Transfection Optimization Kit, SpCas9 nuclease, and controls for a comprehensive experiment.

    Kit Contents

    Includes multiguide sgRNA, SpCas9 EZ Scaffold, buffers, water, and quality control documents for PCR and sequencing.

    Guaranteed Knockouts with Multi-Guide CRISPR

    EditCo’s Gene Knockout Kit uses a multi-guide gRNA approach to ensure reliable and efficient gene disruption. This method targets a single exon with three spatially coordinated gRNAs, creating multiple double-strand breaks and resulting in large fragment deletions. Compared to single-guide CRISPR, our multi-guide strategy significantly increases knockout efficiency, with over 75% large deletions and a 29.2% improvement in knockout success.

    • – High Knockout Efficiency: Multi-guide format provides up to 89.9% knockout success across 32 genetic targets.
    • – Reduced Off-Target Effects: Less occurrence of off-target edits compared to single-guide methods.
    • – Consistent Results: Fragment deletions lead to sustained protein depletion over time, confirmed through Western blot analysis.
    • – Reliable Gene Editing: Achieve complete knockout in just 7 days post-transfection.

    Image: Better knockout efficiency was found across 32 genetic targets assessed.

    Image: EditCo’s Gene Knockout Kit was designed to increase the efficacy of CRISPR-mediated knockouts.

    Image: Multi-guide gRNA for each target resulted in >75% large deletion outcomes.

    Image: Editing of three genes (CDK9, CINP, COASY) in HEK293 cells (transfected via nucleofection) using the multi-guide approach resulted in high knockout efficiencies, as indicated by Knockout (KO) Scores

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    CRISPR Reagents Portfolio

    Gene Knockout kits

    Arrayed gRNA Libraries

    Let’s Find You an Application That Helps Your Research

    Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

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      Knockout T-cells

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      PRODUCTS

      Knockout CD8+ & CD4+ T Cells

      Knockout Tcells

      Advanced CRISPR Knock-Ins for iPSC Research

      EditCo delivers efficient gene editing with guaranteed >80% efficiency in human primary cells, achieving >90% in many cases, using a smart multi-guide design and a 7-day protocol for results in 2 weeks or faster. Their Primary Cell KO Pools produce functionally consistent cell populations, ideal for drug discovery or biological modeling, while maintaining high viability and functionality. Researchers can use EditCo-supplied cells or their own CD8+/CD4+ T cells, ensuring flexibility and reliability. By minimizing failed experiments and false negatives, EditCo saves time and resources, offering 1M-cell EC Pools for high-quality, rapid, and dependable gene editing.

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      EditCo Knockout Immortalized Cells

      Focus on your experiment while they handle CRISPR

      Their KO Primary T-cells ensure >80% editing efficiency, available with EditCo-supplied cells or your own experimental/clinical samples.

      Choose your starting point

      Options include EditCo-supplied cells or customer-provided samples, with edits available for single knockouts using multi-guide synthetic sgRNA.

      Transparent and detailed results

      Receive regular updates, 2 vials of edited cell pools (>1M cells/vial), control-transfected pools, gRNA sequences, NGS primers, sequencing reports, and a detailed QC analysis.

      Reliable and validated outcomes

      Each order includes a QC report with mycoplasma testing, passage number, and NGS analysis to ensure high-quality, functional edited cells.

      Image: High editing efficiency across multiple donors.

      Image: EditCo KO CD8+ T cell pools can be thawed and expanded for weeks, with or without TCR stimulation.

      Next-Level Edited CD8+ T Cells – Powerful, Stable, and Ready for Action

      Take your research further with precision-engineered CD8+ T cells that combine high editing efficiency, long-term stability, and exceptional functionality. Designed to maintain their knockout integrity, expand effortlessly post-thaw, and deliver strong antigen-specific responses, these cells are built for performance. Whether you’re exploring immune responses or advancing cell therapy, these edited T cell pools provide the reliability and power you need.

       

      🔬 Unmatched Editing Precision – Achieve over 90% knockout efficiency across multiple donors, maintaining stability before and after cryopreservation.

      🧬 Thrives & Expands with Ease – These cells stay healthy and proliferate for weeks, with or without stimulation, ensuring flexibility in your experiments.

      ⚡ Optimized for Real-World Function – A single round of activation preserves normal function, preventing overstimulation and exhaustion.

      🎯 Potent, Targeted Cytotoxicity – Strong antigen-specific activation, with robust CD107a expression, ensures effective tumor-killing potential.

       

      Power up your research with CD8+ T cells engineered to perform when it matters most.

      CD4+ T Cells - Stability and Functionality Post-Editing

      The editing of CD4+ T cells has shown high efficiency and stability, with a robust ability to maintain functionality after the editing process. The efficiency of the CD4+ T cell editing was determined through ICE analysis, with results demonstrating high editing efficacy across multiple loci while ensuring cell viability during the freezing stage. Post-editing, the cells can be thawed and expanded without loss of functionality or editing efficiency. Cytokine production in edited T cells, including IFNg, IL2, and TNFa, indicates that the editing process does not negatively impact the cells’ ability to produce essential cytokines upon stimulation. These edited pools also show high viability, making them suitable for further downstream assays.

      • – High editing efficiency of CD4+ T cells determined by ICE analysis.
      • – No reduction in cell viability after freezing, as indicated by flow cytometry
      • – Successful expansion and thawing of edited cells without affecting functionality
      • – Edited cells exhibit high levels of cytokine production (IFNg, IL2, TNFa) post-stimulation 
      • – High viability and expansion potential, with >90% viability after 14 days in culture 
      • – Statistical analysis shows significant cytokine differences between edited and mock cells 

      Image: Editing Efficiency and Viability for CD4+ T cell pools.

      Image: Editing Efficiency leads to protein depletion as shown by flow cytometry

      Image: CD4+ pool stability after thaw.

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      Our team can help you in placing the order. Click below to get a quote and fast ordering.
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      Let’s Find You an Application That Helps Your Research

      Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

        Or give us a call at:

        1300 581 991

        Knockout Immortalized Cells

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        PRODUCTS

        Knockout Immortalized Cells

        Knock-in Immortalized Cell Lines

        Reliable, Reproducible CRISPR Editing for Breakthrough Discoveries

        Spend Less Time on Editing, More on Innovation: EditCo’s advanced automation eliminates time-consuming steps, allowing you to focus on impactful research.

        Superior Performance & Scalability: Our CRISPR platform delivers high knockout efficiencies, ensuring consistent, reproducible results across experiments.

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        EditCo Knockout Immortalized Cells

        Characterize Genes Associated with Neurodegenerative Disease:

        Develop immortalized cell line models to uncover and characterize genes involved in Parkinson’s Disease.

        Investigate a Protein’s Mechanism of Action:

        Accelerate your data generation with high-quality reagents that avoid high off-target issues to quickly and confidently confirm protein function.

        Expedite Drug Discovery
        Research:

        Validate a new drug lead without having to invest time learning or optimizing CRISPR.

        Thoroughly Confirm Your Phenotype in Multiple Models in Parallel:

        Generate data in time for your next board meeting or publication by running assays in parallel to identify your targets.

        XDel Knockout Cell Pools & Clones - EditCo | Decode Science
        XDel Knockout Cell Pools & Clones

        XDel is an advanced CRISPR knockout tool that eliminates uncertainty in gene editing. Using a groundbreaking guide RNA design approach, it provides highly effective, reliable, and repeatable gene knockouts, enabling researchers to speed up their breakthroughs with assurance.

        • – Higher Efficiency & Consistency: XDel technology ensures superior on-target knockout rates with minimal variability.
        • – Reduced Off-Target Effects: Achieve precise edits with lower unintended mutations compared to single-guide methods.
        • – Validated & Scalable: Persistent protein depletion enables direct use in functional assays, drug discovery, and disease modeling.
        CRISPR Knockout Cell Pools & Clones
        CRISPR Knockout Cell Pools & Clones

        Accelerate your research with high-efficiency CRISPR Knockout Cell Pools & Clones from EditCo. Our cell pools provide a mix of edited and unedited cells for immediate assays, while clonal lines ensure precise gene knockouts with sequence-verified accuracy.

        • – 50%+ knockout efficiency in cell pools
        • – Up to 95% protein knockout for functional validation
        • – Single, double, or triple knockouts available
        • – Comprehensive QC & sequencing reports included
        Knockout Cell Libraries – High-Throughput CRISPR Screening Made Easy

        EditCo’s Knockout Cell Libraries enable high-efficiency CRISPR screening with over 90% editing success in a ready-to-use 96-well arrayed format. Designed for functional assays and drug target discovery, our libraries eliminate transfection challenges and infrastructure barriers.

        • – Multi-guide CRISPR design for precise knockouts
        • – High-throughput screening with scalable workflows
        • – Comprehensive QC & sequencing reports included
        • – Compatible with diverse assays for discovery & validation
        Knockout Cell Libraries – High-Throughput CRISPR Screening Made Easy
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        Immortalized Cells Portfolio

        Knockout Immortalized Cells

        Knock-in Immortalized Cells

        Let’s Find You an Application That Helps Your Research

        Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

          Or give us a call at:

          1300 581 991

          Knock-in iPS Cells

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          PRODUCTS

          Knock-in iPS Cells

          iPSC_min

          Advanced CRISPR Knock-Ins for iPSC Research

          EditCo’s advanced CRISPR knock-ins empower neuroscience, cardiovascular, and regenerative medicine research by delivering precise edits in iPSCs while maintaining their quality, pluripotency, and integrity. Our high-throughput automated platform ensures fast lead times and high editing efficiencies, allowing you to focus on downstream applications like assay development and differentiation.

          With minimal off-target effects, our platform offers a range of knock-ins, including single nucleotide variants, tags, and small insertions (<100 bp), available in both homozygous and heterozygous states, as well as in clone or pool formats. Trust EditCo’s robust editing process to accelerate your discoveries with artifact-free, reliable CRISPR-edited iPSCs.

          Get a Quote
          Knock-in Immortalized Cells

          Isogenic Neuronal Lines:

          Create isogenic neuronal lines by reverting disease SNV genotypes to wild type with CRISPR-edited iPSCs.

          Drug Screening:

          Enhance drug screening with gene-corrected control lines for disease-relevant cell types.

          Protein Tagging:

          Tag target proteins to study subcellular localization under endogenous regulation.

          Disease Modeling:

          Model mutations in disease-relevant cell types using high-quality edited iPSCs.

          iPS cells were assessed for standard pluripotency markers

          Image: iPS cells were assessed for standard pluripotency markers, three days post-editing.

          Single-guide RNA Knock-in Cell Pools

          Achieve high-efficiency CRISPR iPSC knock-ins with EditCo’s Knock-in iPS Cell Pools. These pools offer a mix of edited and unedited cells, giving you flexibility for clonal isolation. Our optimized platform ensures precise edits, while you have the option to perform clonal isolation yourself. For those looking for a fully automated process, explore our Knock-in iPS Cell Clones for homogeneity and convenience.

          Features:

          • – Cell Source: EditCo or customer supplied
          • – Available Edits: SNV, Tag, or Insertion
          • – CRISPR Design: Synthetic modified sgRNA, Donor ssODN
          • – Add-ons: QC for pluripotency testing

          Deliverables:

          • – Edited cell pools (2 vials with 5 million cells)
          • – Regular updates, sequencing data, and comprehensive QC reports

          EditCo ensures robust editing with high efficiency across a variety of iPSC lines, maintaining pluripotency and delivering consistent, reliable results.

          Single-guide RNA Knock-in Cell Clones

          EditCo’s Knock-in iPS Cell Clones provide homogeneous populations derived from single CRISPR-edited cells. Skip the editing and cloning process, and move directly into functional assays with high-quality, reliable clones. We manage the entire CRISPR editing and cloning process, ensuring you receive precise, genetically modified clones for accelerated research.

          Features:

          • – Cell Source: EditCo or customer supplied
          • – Genetic Modifications: SNV, Tag, or Insertion (Homozygous or Heterozygous)
          • – CRISPR Design: Synthetic modified sgRNA, Donor ssODN
          • – Add-ons: Additional clones, QC for pluripotency and karyotype testing

          Deliverables:

          • – 2 independent clones with the required knock-in (2 vials of 500,000 cells each)
          • – Regular progress updates, sequencing data, and comprehensive QC reports

          EditCo ensures precise SNV editing and delivers reliable, pluripotent clones ready for your downstream applications.

          SNV editing in iPS cell clones

          Image: 100% SNV editing in iPS cell clones.

          Use EditCo’s iPS Cell Lines or Bring Your Own
          EditCo provides iPS cell lines for all engineered cell orders at no extra cost. Alternatively, you can onboard your own cell lines.

          EditCo-supplied cell lines

          * Parental vials available for evaluation prior to booking an edit

          Ready to Order?
          Our team can help you in placing the order. Click below to get a quote and fast ordering.
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          IPS Cells Portfolio

          Knockout iPS Cells

          Knock-in iPS Cells

          Let’s Find You an Application That Helps Your Research

          Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

            Or give us a call at:

            1300 581 991

            Knockout iPS Cells

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            PRODUCTS

            Knockout iPS Cells

            Knockout iPS Cells

            Precise and efficient models for cutting-edge disease research.

            EditCo’s cutting-edge CRISPR technology ensures accurate and efficient gene editing while maintaining iPSC quality, pluripotency, and overall cell integrity. Our automated platform, optimized guide design, and superior reagents enable high-efficiency knock-ins and knockouts, minimizing errors and off-target effects. With a focus on delivering reliable and functional gene modifications, our robust process allows researchers to confidently assay gene functions, model diseases, and explore new therapeutic targets.

            Whether you need precise knockouts or complex knock-ins, EditCo’s advanced editing solutions provide the accuracy and consistency required for high-impact scientific discoveries in biomedical research.

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            Knock-in Immortalized Cells

            Gene Function Studies:

            Disrupt your target gene to assess its role in a phenotype or cellular function.

            Gene-Disease Linkage:

            Investigate genetic factors in neurodegenerative diseases using edited iPSCs and neuronal cell types.

            Pathway Analysis:

            Knock out genes in your disease pathway. Differentiate cells into disease-relevant types and test for drug targets.

            Target Validation:

            Validate targets in CRISPR-edited iPSCs to confirm gene-disease linkage in cell models.

            Single Guide Pools Results
            XDel Knockout Cell Pools and Clones

            XDel is a CRISPR technology for precise, efficient gene editing. With a unique guide RNA design, it ensures reproducible knockouts without affecting pluripotency or cell integrity, accelerating research in gene function, disease modeling, and drug development.

            • – High Efficiency: Superior editing and consistent knockouts.
            • – Reliable Results: Persistent protein depletion validated through assays.
            • – Reproducibility: Minimized variability for dependable outcomes.
            XDel Knockout Cell Pools & Clones - EditCo | Decode Science
            XDel multiple guide RNA off-target editing efficiency

            Features

            • – Cell Source: EditCo or customer supplied.
            • – Available Edits: Indel, fragment deletion, homozygous, or heterozygous.
            • – Design: Synthetic modified sgRNA.
            • – Add-Ons: Additional clones, testing.
            • – Deliverables: Updates, edited cell pools (2 vials), sequencing data, and QC reports.

            Superior Editing
            XDel offers more consistent and efficient on-target editing than single-guide RNA methods, ensuring reliable results.

            Reduced Off-Target Effects
            XDel delivers lower off-target editing compared to single-guide RNA, ensuring better precision.

            Robust Knockouts
            XDel pools maintain genomic stability, confirmed by karyotyping and PluriTest™.

            How XDel Works
            XDel uses up to 3 coordinated guides for reliable knockouts, offering more consistent edits than traditional single-guide methods.

            XDel pools and clones
            Multi-guide schematic-new
            Ready to Order?
            Our team can help you in placing the order. Click below to get a quote and fast ordering.
            Get a Quote
            IPS Cells Portfolio

            Knockout iPS Cells

            Knock-in iPS Cells

            Let’s Find You an Application That Helps Your Research

            Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

              Or give us a call at:

              1300 581 991

              Knock-in Immortalized Cells

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              PRODUCTS

              Knock-in Immortalized Cells

              Arrayed CRISPR sgRNA Libraries

              Get CRISPR-Engineered Cell Lines Faster and More Efficiently.

              EditCo’s Knock-in Immortalized Cells provide a fast and efficient way to integrate engineered cells into your research, using automated transfection optimization and RNP-based delivery to ensure high editing success with minimal off-target effects.

              By eliminating the delays and challenges of DIY CRISPR projects, our cost-effective solution enables you to model more genes and variants across multiple cell lines, accelerating your path to discovery without overspending.

              Get a Quote
              Knock-in Immortalized Cells

              Tag and Quantify Your Protein:

              Easily purify and measure your target protein with
              precise tagging.

              Create a Disease Model:

              Modify genes to introduce or correct mutations for studying disease phenotypes.

              Analyze Gene Regulation:

              Develop reporter cell lines with promoter tags to monitor
              gene activity.

              Uncover Protein Interactions:

              Use affinity tags to map protein-protein interactions and identify key partners.

              Single Guide Pools Results
              Cost-Effective CRISPR Knock-in Cell Pools – Flexible & Efficient

              EditCo’s Knock-in Immortalized Cell Pools provide a high-throughput, budget-friendly solution for introducing precise edits while maintaining a mixed population of edited and unedited cells.

              • – Optimized transfection for high-efficiency knock-ins
              • – Supports SNVs, tags, and large insertions with advanced HDR strategies
              • – Flexible clonal isolation—manage it yourself or opt for our Knock-in Clones
              • – Comprehensive QC & sequencing reports for reliable validation
              Precision-Verified CRISPR Knock-in Clones – Ready for Your Research

              EditCo’s Knock-in Immortalized Cell Clones provide a sequence-verified, clonal population for precise, high-quality knock-ins. Whether modifying SNVs, tagging proteins, or inserting large sequences, our automated isolation process ensures you receive a single-cell-derived clone with your desired edit.

              • – Guaranteed precision with fully validated knock-ins
              • – Endogenous tagging & SNV editing for functional studies
              • – Streamlined delivery with complete QC & sequencing reports
              • – Customizable options including additional clones & intermediate pools

              Skip the complexity—get ready-to-use, precision-edited clones with EditCo!

              Ready to Order?
              Our team can help you in placing the order. Click below to get a quote and fast ordering.
              Get a Quote
              Immortalized Cells Portfolio

              Knockout Immortalized Cells

              Knock-in Immortalized Cells

              Let’s Find You an Application That Helps Your Research

              Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

                Or give us a call at:

                1300 581 991