CNV Backbone Spike-in Panels

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Twist CNV Backbone Spike-in Panel with exome for cytogenetic research
Stronger CNV Detection — Without Changing Your Exome Workflow.

Large copy number variations can be easy to miss when exome sequencing focuses on exonic regions – leading to blind spots, repeat testing, and extra time interpreting unclear data. By spiking in Twist’s CNV Backbone Panels, you give your exome run the evenly spaced genomic coverage it needs to reliably surface clinically relevant CNVs — especially the ones standard exomes struggle with.

Available in 100 kb, 50 kb, and 25 kb resolutions, the CNV Backbone Panels strengthen your detection sensitivity while keeping your workflow identical. Blend it into your existing exome panel, follow your standard Twist enrichment protocol, and immediately get more confident CNV calls backed by consistent probe tiling across intergenic regions.

But... Why These Panels?

1. Fine-Tune CNV Resolution

Choose from 100 kb, 50 kb, or 25 kb probe spacing to match your CNV detection needs. Strategically tiled probes in intergenic regions enhance sensitivity for even small CNVs.

2. Seamless Workflow Integration

Easily spike into your Twist Exome 2.0 panel and follow standard enrichment protocols—no workflow disruption, no extra training required.

3. Evidence-Based Performance

Validated with highly characterized samples, the panels consistently improve CNV calls, including those smaller than 50 kb, boosting confidence in your results.

4. Flexible Panel Sizes

Available in 2-reaction (16 samples) and 12-reaction (96 samples) formats to fit both small-scale research and high-throughput lab workflows.

Download Poster on utilization of these panels with exome for cytogenetic research

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    Why It Matters to You

    Reliable CNV detection isn’t just a technical metric—it directly impacts research outcomes, diagnostic accuracy, and patient care. Standard exome sequencing often misses CNVs due to uneven probe coverage, creating blind spots in your analysis. Twist CNV Backbone Spike-in Panels bridge those gaps, ensuring that even subtle copy number changes are identified, so you can make confident, data-driven decisions.

    For labs and clinicians, this means fewer follow-up tests, reduced time spent troubleshooting ambiguous results, and a smoother workflow. You can trust that your exome sequencing captures the variations that truly matter, whether for rare disease research, clinical diagnostics, or high-throughput screening.

    Moreover, the ability to choose between 25 kb, 50 kb, or 100 kb resolution gives you control over sensitivity and throughput, aligning with your project goals and patient population needs. Evidence-based validation demonstrates improved detection of CNVs—including those smaller than 50 kb—so your results aren’t just comprehensive, they’re actionable.

    By integrating these panels into your existing workflow, you enhance not only the quality of your data but also the efficiency of your lab operations, freeing time and resources for deeper analysis and patient-focused outcomes.

    Select the CNV Resolution You Need

    Select CNV Resolution You Need

    Table 1. Example data of Twist CNV Backbone Spike-in Panels. A highly characterized sample set known to contain CNVs (1) and a baseline set of 12 healthy individuals were sequenced with 2×150 reads on an Illumina NovaSeq 6000. The average number of SNVs, INDELs, and CNVs called and sequencing depth at each probe density was determined for each panel when spiked into Twist Exome 2.0 plus Comprehensive Spike-in. CNV calling was performed with a commercially available software solution (2)
     

    (1) Coriell Institute’s CNVPANEL01 – Human CNV Reference Panel.
    (2) eVai Platform (secondary workflow), enGenome Software. 

    Related Products

    Twist Exome 2.0

    Leading exome solution covering key genetic databases with high uniformity

    Twist Standard Hybridization Reagent Kit

    Reagents for high-efficiency NGS target enrichment (TE).

    Library Preparation Enzymatic Fragmentation Kit 2.0

    Enzymatic DNA fragmentation for efficient library prep.

    Ordering
    Higher Resolution: 

    110756  –  Twist 25kb CNV Backbone Spike-in Panel, 2 Reaction kit

    110757  –  Twist 25kb CNV Backbone Spike-in Panel, 12 Reaction kit

    Intermediate Resolution:

    110758 –  Twist 50kb CNV Backbone Spike-in Panel, 2 Reaction kit

    110759 –  Twist 50kb CNV Backbone Spike-in Panel, 12 Reaction kit

    Lower Resolution: 

    110760 –  Twist 100kb CNV Backbone Spike-in Panel, 2 Reaction kit

    110761 –  Twist 100kb CNV Backbone Spike-in Panel, 12 Reaction kit

    Exome Panels

    104132 –  Twist Exome 2.0, 2 Reactions, Kit

    104134 –  Twist Exome 2.0, 12 Reactions, Kit

    104136 –  Twist Exome 2.0, 96 Reactions, Kit

    105034 –  Twist Exome 2.0 plus Comprehensive Exome Spike-in, 2 Reactions

    105035 –  Twist Exome 2.0 plus Comprehensive Exome Spike-in, 12 Reactions

    105036 –  Twist Exome 2.0 plus Comprehensive Exome Spike-in, 96 Reactions

    *For research use only 

    Chris Wicky

    Clinical Genomics Manager - ANZ
    & Country Manager - NZ

    For guidance on integrating these panels into your operations, Decode Science can provide personalised support and local assistance.
    TALK TO ME DIRECTLY
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      * This promo is only available to customers in the Asia Pacific region (excluding China and Japan). Pricing is subjected to changes.
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      Introducing CHO and HEK293 Antibody Production

      Twist Bioscience helps researchers speed up antibody discovery with Express Antibody Production using CHO and HEK293 expression systems. Our high-throughput antibody production platform can generate anywhere from dozens to thousands of antibodies, enabling efficient antibody screening for binding specificity and biophysical properties.

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        RNA Sequencing

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          Customized Panel Designs:
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              NGS Portfolio

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                Clonal Genes

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                Clonal Genes

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                Overview

                Twist Bioscience’s advanced platform is designed to meet diverse DNA synthesis needs, with the capability to synthesize hundreds of thousands of genes each month. Utilizing a silicon-based platform for DNA synthesis, Twist delivers highly precise, sequence-perfect clonal genes of various lengths and complexities, all verified through Next-Generation Sequencing (NGS). Now, with the introduction of the Express Genes service, Twist offers even faster turnaround times, synthesising NGS-verified Clonal Genes in as few as 5 days.

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                Low Cost – High Quality:

                Priced from 18¢ (AUD) per base pair.

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                Delivery in as fast as 12 business days.

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                Four preparation scales (50ng – 2µg | 2µg – 10µg | 10µg – 100µg | 100µg – 1mg).

                Options for normalization and endotoxin-free available.

                Scalable Synthesis:

                No order limits, providing flexibility.

                Same turnaround time regardless of order size.

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                Express Genes Service

                Introducing Twist Bioscience’s Express Genes service*— synthesising NGS-verified, sequence-perfect Clonal Genes with an unprecedented order-to-ship turnaround time of 5-7 business days. Explore our full Clonal Genes offering below and experience the speed and efficiency of Express Genes for your research needs.

                Genes Table (Clonal and Express Gene)

                *Terms and Conditions: Eligible Express Genes ship in 5-7 business days. This time will vary based on complexity and length of the sequence. Orders placed outside of the US will incur additional delivery turnaround time. Turnaround time for Clonal Genes is subject to change based on customizations and complexity. Average turnaround time for Clonal Genes is 10-15 business days. New vector onboarding for both Express Genes and Clonal Genes will add additional time.

                DATA

                The data presented illustrates the high quality and precision of Twist Bioscience’s Clonal Genes, showcasing a graphical representation of the standard Next-Generation Sequencing (NGS) verification performed on each clonal gene. The featured clonal gene in the figure serves as an example of an error-free clone. The read depth is indicated for the entire plasmid, and no Single Nucleotide Polymorphisms (SNPs) or insertions/deletions (indels) were detected, emphasizing the accuracy and reliability of Twist’s clonal gene synthesis.

                This data emphasizes Twist’s commitment to providing researchers with sequence-perfect clonal genes, ensuring high-quality and error-free results for a wide range of applications in the field of genetic research and synthetic biology.

                Clonal Genes
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                Gene Fragments

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                  Gene Fragments

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                  Gene Fragments

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                  Overview

                  Twist Bioscience offers Synthetic Gene Fragments as a fast, economical, and efficient solution for building genes in your research. These gene fragments enhance the cloning process by minimizing the need for colony screening, saving valuable time and reducing overall costs associated with cloning and sequencing.

                  By leveraging Twist’s Synthetic Gene Fragments, researchers can think bigger, design on a grander scale, and accelerate their discoveries. With the advantage of an industry-leading error rate, customizable lengths and yields, and the convenience of no order limits, Twist’s Gene Fragments offer a cost-effective and time-efficient solution for diverse research needs. To learn more or place an order, researchers can explore the product sheet or directly proceed with ordering from Twist Bioscience.

                  Fast and Economical:

                  Gene Fragments for assembly and cloning.
                  Compatible with all downstream cloning methods.
                  Priced from 13¢ (AUD) per base pair.
                  Synthesised in as little as 2 business days.

                  Screen Less, Discover More:

                  Industry-leading error rate of 1:7500.
                  Length: 300 bp – 1800 bp.
                  Yield: 100 ng – 1 µg.
                  No order limit.

                  Get a Quote

                  Twist Bioscience’s DNA synthesis technology stands out by outperforming competitors with exceptionally low error rates. In a direct comparison of Gene Fragment products, Twist consistently demonstrated the lowest error rate, as illustrated in the graph comparing Twist and Integrated DNA Technologies, Inc. (IDT). The results reveal that Twist Gene Fragments exhibit greater sequence accuracy compared to eBlocks and gBlocks, boasting an average of 2-fold greater accuracy in sequence fidelity over gBlocks.

                  Moreover, Twist Gene Fragments consistently yield the highest percentage of perfect clones, offering a significant advantage in terms of time and cost savings for researchers. The graph showcasing a direct comparison of the percentage of sequence perfect clones across various gene lengths and sequences for three different gene products highlights Twist’s superiority. The data, derived from a set of 63 sequences with diverse gene lengths, reflects the broad applicability of Twist’s technology in addressing the varied requirements of real-world synthetic biology applications.

                  Gene-Fragments-AverageErrorRate-3
                  perfect-clones-bp-length@2x
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                  SynBio Genes Portfolio

                  Gene Fragments

                  Clonal Genes

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