RNA Cartridges

December 21, 2023/in BiOptic, Consumables, Partners/by Harshita Sharma

PRODUCTS

RNA Cartridges

R1 RNA Cartridge Kit

The cartridge is ideal for low concentration RNA analysis and the analysis time is between 5~7 minutes.
The system provides RNA Quality Number (RQN) for total RNA integrity reference.
Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.
The cartridge can be stored at room temperature (15~27°C) and is valid for 4 months.

NR1 High Sensitivity RNA Cartridge Kit

The cartridge is ideal for low concentration RNA analysis (LOD 1 ng/μl) and the analysis time is between 5~7 minutes.
The system provides RNA Quality Number (RQN) for total RNA integrity reference.
Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.
The cartridge can be stored at room temperature (15~27°C) and is valid for 4 months.

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Protein Cartridges

December 21, 2023/in BiOptic, Consumables, Partners/by Harshita Sharma

PRODUCTS

Protein Cartridges

P2 Protein Cartridge Kit

The cartridge analyzes protein sample size and purity with higher sensitivity and resolution.
The analysis size range is 11~155kDa but the detection range is up to 600kDa.
Qsep100 Advance is the recommended platform for detecting fluorescent-labeled protein sample.
Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.

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Quantification Kit

December 21, 2023/in BiOptic, Consumables, Partners/by Harshita Sharma

PRODUCTS

Quantitative Kit

S2 Standard Quantitative Cartridge Kit

The fragment sizes and relatively accurate quantitative results can be obtained simultaneously. Extra time and cost for quantitative analysis can be saved.
S2 cartridge is for PCR products, small-sized DNA, and NGS quality control (Fragmentation and Library sample) analyses.
The analysis time is about 3 minutes, and the best resolution is 4~10bp if the sample size is less than 500bp.
Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 6 months.

S1 High Resolution Quantitative Cartridge Kit

The fragment sizes and relatively accurate quantitative results can be obtained simultaneously. Extra time and cost for quantitative analysis can be saved.
Not only the total concentration but also the individual fragment concentration can be provided.
The analysis time is about 3~5 minutes, and the best resolution is 1~4bp if the sample size is less than 500bp.
Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 6 months.

N1 High Sensitivity Quantitative Cartridge Kit

The fragment sizes and relatively accurate quantitative results of low concentration DNA can be obtained simultaneously with individual fragment concentration provided.
The applications include low concentration DNA fragments and cell-free DNA quality control.
The analysis takes about 3 minutes with a recommended size range up to around 5,000bp and a detection limit of about 10 pg/μl.
Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 4 months.

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S2 Cartridge (Standard Cartridge) BiOptic

DNA Cartridges

December 21, 2023/in BiOptic, Consumables, Partners/by Harshita Sharma

PRODUCTS

DNA Cartridges

S2 Standard Cartridge Kit

S2 cartridge is for PCR products, small-sized DNA, and NGS quality control (Fragmentation and Library sample) analyses.
The analysis time is 2~3 minutes and the best resolution is 4~10bp if the sample size is less than 500bp.
It has a recommended size range up to around 5,000bp and a detection limit of about 0.1 ng/μl in low concentration.
Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 6 months.

S1 High Resolution Cartridge Kit

The analysis time is 2~5 minutes and the best resolution is 1~4bp if the sample size is less than 500bp.
It provides high resolution result with multiple methods from low to high voltage (2~10kV) for user to choose from.
It has a recommended analysis range up to around 5,000bp and a detection limit of about 0.1 ng/μl in low concentration.
Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 6 months.

S3 Kilobase Cartridge Kit

S3 cartridge is for large-sized DNA analysis.
It has a recommended 5~165kb size range and is ideal for quality control of second and third generation sequencing.
The system provides DNA Quality Number (DQN) for gDNA integrity reference.
Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 6 months.

F3 Fast Cartridge Kit

The analysis time is 90 seconds and can be applied to PCR product analysis.
It has a recommended analysis range up to around 5,000bp for DNA.
It runs on Qsep100 and Qsep400 only.
Each cartridge can analyze 300 runs for single-channel cartridge or 1200 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 4 months.

N1 High Sensitivity Cartridge Kit

The sample concentration for analysis has a detection limit of about 5 pg/μl (or 1 pg/μl if dissolved in ddH2O) and the analysis time is about 3 minutes.
It can be used for analysis of low concentration DNA fragment and quality control of cell-free DNA.
It has a recommended analysis range up to around 5,000bp for DNA.
Each cartridge can analyze 100 runs for single-channel cartridge or 400 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 4 months.

N3 High Sensitivity Kilobase Cartridge Kit

N3 cartridge is for low concentration large-sized DNA analysis.
It has a recommended 5~165kb size range and is ideal for quality control of second and third generation sequencing.
The system provides DNA Quality Number (DQN) for gDNA integrity reference.
Each cartridge can analyze 200 runs for single-channel cartridge or 800 runs for 4-channel cartridge.
The cartridge can be stored at 4~27°C and is valid for 4 months.

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Qsep1-Plus

December 21, 2023/in BiOptic, Instruments, Partners/by Harshita Sharma

PRODUCTS

Qsep1-Plus

Smallest/portable-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.

Qsep1-Plus is ideal for small laboratories with low throughput (1~15 samples) needs.

The system supports Wi-Fi and cable connections, breaking the barriers of space.

10+ types of cartridges can be easily exchanged between various applications.

The provided quantitative method delivers fragment size and concentration information in one run.

Qsep1-Plus has the highest specification product among all portable automated Bio-Fragment Analyzers. Advantages of capillary electrophoresis are high resolution (1~4bp if less than 500bp), high sensitivity (5pg/μl) and significantly faster preparation and analysis time. Besides analyzing fragment sizes and concentrations, it is also suitable for quality control of next-generation sequencing (NGS).

Qsep1-Plus is equipped with completed hardware and software and has fully functional remote access via cable/Wi-Fi. The system provides various kinds of applications such as RNA quality control with RNA Quality Number (RQN) provided, auto-distribution of NGS QC and quality control of gDNA with DNA Quality Number (DQN) provided. Qsep1-Plus is a top choice for modern small or medium-sized laboratory.

Qsep series can not only replace the complicated and time-consuming gel preparation and analysis procedure, but increase the accuracy of analysis, elevate efficiency and reproducibility, and reduce the human error and costs.

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BiOptic Instruments Portfolio

Qsep100

Qsep1

Qsep400

Qsep1+

Qsep100 Advance

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Qsep400

December 21, 2023/in BiOptic, Instruments, Partners/by Harshita Sharma

PRODUCTS

Qsep400

4-channel Bio-Fragment Analyzer designed for medium and large-sized labs, offering higher throughput and faster analysis.

Qsep400 features an integrated PC and touchscreen for user-friendly operation.

Capable of analyzing DNA, RNA, or protein with a 4~96 sample capacity.

Quantitative method provides comprehensive fragment size and concentration data in a single run.

Qsep400 is a high-throughput automated Bio-Fragment Analyzer. It is the highest specification product of Qsep series and can analyze hundreds of samples in one day. It supports various types of applications, including DNA, RNA and protein fragment analyses and high-voltage fast analysis. Advantages of capillary electrophoresis are high resolution (1~4bp if less than 500bp), high sensitivity (5pg/μl) and significantly faster preparation and analysis time. Besides analyzing the fragment sizes and concentrations, it is also a tool for quality control, and is best for NGS facilities and research centers.

Qsep400 is equipped with an integrated PC and touchscreen and can be directly controlled and analyzed. The system provides applications such as RNA quality control with RNA Quality Number (RQN) provided, auto-distribution of NGS QC and quality control of gDNA with DNA Quality Number (DQN) provided. Qsep400 is an independent and highly-efficient instrument.

Qsep series can not only replace the complicated and time-consuming gel preparation and analysis procedure, but increase the accuracy of analysis, elevate efficiency and reproducibility, and reduce the human error and costs.

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Qsep100

December 21, 2023/in BiOptic, Instruments, Partners/by Harshita Sharma

PRODUCTS

Qsep100

Standard-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.

Ideal for small to medium-sized labs with 1~96 sample capacity.

Easily exchangeable cartridges for versatile applications.

Provides quantitative data on fragment size and concentration in a single run.

Efficient Bio-Fragment Analysis with Qsep100

The Qsep100, a standard-sized automated Bio-Fragment Analyzer, represents the classic model in the Qsep series. Boasting a single-channel design, it can seamlessly process 1 to 96 samples, making it an ideal choice for small and medium-sized laboratories. This high sample flexibility extends to various applications, including DNA, RNA, and protein fragment analyses, as well as high-voltage fast analysis.

Versatility for Various Applications

The Qsep100 supports a range of applications, offering RNA quality control with the provision of RNA Quality Number (RQN), automated distribution of NGS QC, and quality control of genomic DNA (gDNA) with the availability of DNA Quality Number (DQN). Particularly, it stands out as a top choice for Next-Generation Sequencing Quality Control (NGS QC).

Streamlining Processes and Enhancing Accuracy

The Qsep series, including the Qsep100, eliminates the need for intricate and time-consuming gel preparation and analysis procedures. This not only increases the accuracy of analysis but also elevates overall efficiency and reproducibility while reducing human errors and costs. Invest in Qsep100 for a seamless, reliable, and efficient bio-fragment analysis experience.

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Qsep1

December 21, 2023/in BiOptic, Instruments, Partners/by Harshita Sharma

PRODUCTS

Qsep1

Smallest/portable-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.

Ideal for small laboratories with low throughput needs (1~8 samples).

Supports Wi-Fi and cable connections, enhancing spatial flexibility.

Easy exchange of 10+ cartridges between various applications.

Quantitative method provides fragment size and concentration info in a single run.

Qsep1 is an automated Bio-Fragment Analyzer for DNA, RNA and protein fragments. Advantages of capillary electrophoresis are high resolution (1~4bp if less than 500bp), high sensitivity (5pg/μl) and significantly faster preparation and analysis time. Besides analyzing fragment sizes and concentrations, it is also suitable for quality control of next-generation sequencing (NGS).

Qsep1 is equipped with completed hardware and software and has fully functional remote access via cable/Wi-Fi. The system provides various kinds of applications such as RNA quality control with RNA Quality Number (RQN) provided, auto-distribution of NGS QC and quality control of gDNA with DNA Quality Number (DQN) provided. Qsep1 is a top choice for modern small laboratory.

Qsep series can not only replace the complicated and time-consuming gel preparation and analysis procedure, but increase the accuracy of analysis, elevate efficiency and reproducibility, and reduce the human error and costs.

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Viral Controls

December 20, 2023/in Partners, Synthetic Controls, Twist/by Harshita Sharma

PRODUCTS

Synthetic Viral Controls

Trusted Controls for Diverse Applications

In the wake of the global demand for diagnostic tests amid the Coronavirus pandemic, laboratories worldwide seek reliable tools for detecting SARS-CoV-2 and Respiratory viruses across various sample types. Our controls offer a trusted solution to address the expanding need for testing, ensuring accuracy and safety in a wide range of applications.

Ensuring Reproducible, High-Quality Results

Positive controls play a pivotal role in maintaining quality standards for diagnostic assays, spanning from development to day-to-day testing. These controls facilitate the verification and validation of diagnostic tests, supporting both next-generation sequencing (NGS) and reverse transcription polymerase chain reaction (RT-PCR) assays, ensuring reproducibility and reliability.

Safe and Effective Alternatives to “Live Virus”

Concerns regarding safety and security associated with controls based on viral nucleic acids extracted from infected patients or live virus cultures led us to develop synthetic controls through gene synthesis. These alternatives offer a safe and effective solution, allowing broader access to diverse strains while mitigating potential risks.

Flexible Formulations for Varied Needs

Tailor your approach with our flexible control formulations—Standard, Assay Ready, or Encapsulated. Whether in a frozen liquid, dried pellet, or encapsulated dried pellet form, our controls provide options for shipping, storage, and stability, meeting the unique requirements of your applications. Ambient shipping reduces costs and enhances accessibility for researchers globally, making our controls a reliable choice in the dynamic landscape of diagnostic testing.

RESPIRATORY VIRUS CONTROLS

Comprehensive Controls for Respiratory Virus Research

Twist’s Synthetic Respiratory Virus Controls encompass a wide spectrum of RNA and DNA viruses crucial for respiratory disease studies. Aligned with the Twist Respiratory Virus Research Panel (PN 103067), these controls seamlessly integrate into Twist Fixed Panel NGS workflows, as well as RT-PCR or qPCR experiments designed by users.

Navigating the Viral Landscape

Refer to the taxonomic tree in the accompanying figure for a visual representation of the viruses covered by Twist Respiratory Virus Controls. The table provides GenBank IDs, virus types, and lengths for each control, facilitating an in-depth understanding of the viral landscape. Custom synthesis options are also available—connect with your local sales representative for additional details.

Simplify Your Research Journey

For further information or to make a purchase, contact your local sales representative or conveniently “Buy Now.” Twist’s Synthetic Respiratory Virus Controls offer a robust foundation for respiratory virus research, enhancing the precision and reliability of your experiments.

SARS-COV-2 CONTROLS

Elevating Quality Control with Twist Synthetic RNA Controls for SARS-CoV-2

Twist Bioscience offers synthetic RNA controls designed for diverse viral genomes, including SARS-CoV-2. With six non-overlapping 5 kb fragments transcribed into ssRNA, these controls provide over 99.9% genome coverage. Available in standard, Assay Ready, and Encapsulated Formats, they cater to various needs with concentrations tailored for flexibility.

Unique Stability in Encapsulated Controls

Twist’s Encapsulated Controls, sealed in a metal capsule around a desiccated pellet, ensure enhanced stability. With room temperature shipping and a five-year shelf life, these controls provide cost-effective and globally accessible solutions.

Contribution to Multiplex Assay Development

The Twist Assay Ready Synthetic SARS-CoV-2 RNA Control, developed with the US CDC, enables simultaneous testing for influenza A, B, and SARS-CoV-2. Originally designed for authorized laboratories, it is now available to customers outside the CDC.

Best Practices and Regulatory Considerations

For comprehensive guidance on storage and use of controls, refer to provided documents: Twist Assay Ready Synthetic Controls Storage and Use Document and Twist Sars-CoV-2 Encapsulated RNA Control Storage and Handling Guide.

Note: This product is authorized for emergency use by the FDA under an EUA for the detection of SARS-CoV-2 nucleic acid. The emergency use is limited to circumstances justifying the authorization.

MONKEYPOX CONTROLS

Twist Synthetic hMPXV Controls: Precision for Targeted Research

Twist’s Synthetic Human Monkeypox Virus (hMPXV) Controls, representing CB and WA clades, cover over 80% of the viral genome. Validated for custom assays and compatible with CDC-recommended PCR procedures, these controls, in two variants, offer precise tiling of the genome at 900bp intervals. With concentrations at approximately 100,000 copies/uL, they provide accuracy and reproducibility. Contact your local sales representative for more information.

Note: The Twist Synthetic hMPXV Controls are not ISO-13485 certified.

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Synthetic Controls Portfolio

cfDNA Pan Cancer Reference standards

Viral
Controls

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cfDNA Pan-cancer Reference Standards

December 20, 2023/in Partners, Synthetic Controls, Twist/by Harshita Sharma

Twist cfDNA Pan-Cancer Reference Standard v2

The Twist cfDNA Pan-Cancer Reference Standard v2 is a meticulously engineered tool tailored for genomics professionals developing and validating NGS-based liquid biopsy assays. This reference standard provides a reliable and reproducible resource for detecting clinically relevant variants, enabling researchers to confidently evaluate assay performance at every stage. By integrating a wild-type (WT) cell-free DNA (cfDNA) background with synthetic oligonucleotides carrying mutant alleles, the material delivers exceptional precision and sensitivity.

Researchers can leverage this standard to define critical analytical parameters, including the Limit of Detection (LoD) and Limit of Blank (LoB), ensuring robust assay calibration and quality control. Ideal for both early-stage assay development and ongoing process monitoring, the Twist cfDNA Pan-Cancer Reference Standard v2 empowers genomics teams to accelerate liquid biopsy innovation while maintaining rigorous accuracy and reproducibility.

But... Why These Panels?

Comprehensive Detection of Cancer Variants

458 unique naturally occurring cancer variants

132 clinically relevant variants

Covers 84 different genes involved in cancer

Better Design of Background
DNA

Background DNA derived from human cfDNA samples

DNA size profile and post-sequencing profile mimic native cfDNA

Designed for Precision and Flexibility

Seven individual VAF percentages to choose from

Digital Droplet PCR verification of VAF percentages

Convenient test set of all VAF percentages available

Download Product Sheet, Data Files & Detailed FAQs

Unlock instantly with few steps.

Data To Back This Up

Fragment Profile Comparison: Twist vs. Competitors

Twist cfDNA Pan-Cancer Reference Standard v2 closely mimics the fragment size distribution of native cfDNA, including distinct mononucleosomal and dinucleosomal peaks. When compared to competitor reference materials standardized for peak height, Twist’s standards provide a more biologically accurate representation of circulating cell-free DNA, supporting realistic assay development and reliable performance benchmarking.

Schematic of Synthetic Variant DNA Design

Twist’s synthetic variant DNA is engineered to tile across each genomic locus with extensive overlap, ensuring high coverage and diverse fragment representation. This design captures the variant in multiple positions relative to the DNA termini, providing realistic fragment diversity and enabling more accurate assay performance assessment.

Background Mutation Rate Comparison

Background mutation rate measures the occurrence of non-germline variants in duplex consensus reads from target-enriched wild-type samples. Analysis across Twist cfDNA Pan-Cancer Reference Standard v2, native cfDNA, competitors, and Twist v1 shows that v2 closely matches the low background error rate of native cfDNA. Its superior fidelity—lower than both v1 and competitor standards—is achieved through a high-precision production process, ensuring more reliable and accurate assay benchmarking.

INDEL Size Distribution

The Twist cfDNA Pan-Cancer Reference Standard v2 includes a wide range of insertion and deletion (INDEL) sizes, from deletions of 30 bp to insertions of 15 bp. Visualized as a histogram (bin width = 1), this distribution allows researchers to comprehensively evaluate INDEL detection performance across diverse fragment lengths. Single nucleotide variants (SNVs) are not included in this visualization, highlighting the standard’s focus on structural variant representation and assay sensitivity testing.

Variant Calling in Target Enrichment Workflows

Twist cfDNA Pan-Cancer Reference Standards deliver highly accurate variant detection across a range of variant allele frequencies (VAFs). Using a custom panel targeting 215 SNVs and sequencing to 80,000× raw coverage before UMI deduplication, the observed mean VAFs closely match the intended levels. This precision allows researchers to confidently benchmark and validate their NGS-based assays, ensuring reliable performance across the full spectrum of variant frequencies.

Archive for month: December, 2023

RNA Cartridges

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Protein Cartridges

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Quantitative Kit

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DNA Cartridges

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Qsep1-Plus

Smallest/portable-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.

Qsep1-Plus is ideal for small laboratories with low throughput (1~15 samples) needs.

The system supports Wi-Fi and cable connections, breaking the barriers of space.

10+ types of cartridges can be easily exchanged between various applications.

The provided quantitative method delivers fragment size and concentration information in one run.

Have a question?

Qsep400

4-channel Bio-Fragment Analyzer designed for medium and large-sized labs, offering higher throughput and faster analysis.

Qsep400 features an integrated PC and touchscreen for user-friendly operation.

Capable of analyzing DNA, RNA, or protein with a 4~96 sample capacity.

Quantitative method provides comprehensive fragment size and concentration data in a single run.

Have a question?

Qsep100

Standard-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.

Ideal for small to medium-sized labs with 1~96 sample capacity.

Easily exchangeable cartridges for versatile applications.

Provides quantitative data on fragment size and concentration in a single run.

Have a question?

Qsep1

Smallest/portable-sized capillary electrophoresis Bio-Fragment Analyzer for DNA, RNA, and protein.

Ideal for small laboratories with low throughput needs (1~8 samples).

Supports Wi-Fi and cable connections, enhancing spatial flexibility.

Easy exchange of 10+ cartridges between various applications.

Quantitative method provides fragment size and concentration info in a single run.

Have a question?

Synthetic Viral Controls

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Comprehensive Detection of Cancer Variants

Better Design of Background DNA

Designed for Precision and Flexibility

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Chris Wicky

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FREE UMBRELLA

Better Design of Background
DNA