Compute Solutions

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Compute Solutions

Experience comprehensive solutions for Optical Genome Mapping (OGM) data management and processing with Bionano Compute. Our suite encompasses a full spectrum of hardware, software, and cloud-based solutions, ensuring a seamless workflow from start to finish.

Bionano Compute offers end-to-end experiment management and bioinformatics processing, empowering researchers with robust tools for efficient data analysis. Additionally, it provides convenient management and monitoring tools tailored for the Saphyr™ and Stratys™ instruments, streamlining operations and enhancing productivity.

With Bionano Compute, researchers can harness the power of advanced technology to unlock insights from genomic data with unparalleled ease and efficiency.

The Stratys™ Compute high-performance workstation ensures seamless scalability for your workflow demands.

Fueled by NVIDIA RTX GPUs, it offers expedited runtimes and reduced compute costs, thanks to its cutting-edge technology. With each software release, expect accelerated performance, enhancing overall efficiency.

Experience unparalleled sensitivity in detecting all classes of structural variants (SVs) across the genome with the latest informatics pipeline tailored for Optical Genome Mapping (OGM) data.

Installed alongside the Stratys instrument, the Stratys Compute workstation minimizes IT burdens and implementation time, optimizing your setup for streamlined operations.

Reduce infrastructure costs and expand your Optical Genome Mapping (OGM) capacity effortlessly with Bionano Compute On Demand.

This pay-per-use solution, accessible via the Bionano Access web server for Bionano Solve operations, revolutionizes OGM data analysis from the Saphyr™ or Stratys™ instruments without necessitating additional infrastructure. Enjoy the flexibility and scalability your experiments demand with Compute On Demand.

Key advantages of Compute On Demand include:

Analyze large genomes and numerous samples simultaneously, maximizing throughput and efficiency.
Perform pipeline analysis operations seamlessly, without concerns about server capacity constraints.
Safeguard data integrity with encryption measures, ensuring secure operations and compliance with data protection regulations.
Maintain data center compliance with IPAA, CSA, SOC2, and ITAR regulations, guaranteeing adherence to industry standards and regulations.

With Bionano Compute On Demand, unlock the full potential of your OGM experiments while optimizing costs and maintaining data security and compliance.

Experience high-speed, on-site Optical Genome Mapping (OGM) data processing tailored for the Saphyr™ with the Saphyr™ Compute Server.

This compact solution delivers cluster-like performance at an affordable cost, revolutionizing your data analysis capabilities.

Key features of the Saphyr™ Compute Server include:

Cluster-like Performance: Enjoy the power of multiple simultaneous analyses and sustained throughput, reducing downtime and accelerating your research.
Rapid Analysis: Perform rare variant analysis and annotation of a human genome in approximately nine hours, enabling swift insights into complex genomic structures.
User-Friendly Interface: Seamlessly integrate the Saphyr™ Compute Server into any network setup with its simple web-based interface, ensuring compatibility and ease of use.

With the Saphyr™ Compute Server, spend less time waiting for data and more time delving into meaningful results, advancing your research endeavors with unparalleled efficiency and speed.

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Sample Preparation Kits

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Sample Preparation Kits

Effortlessly prepare samples for Optical Genome Mapping (OGM) with Bionano’s comprehensive Sample Preparation Solutions, ensuring accurate identification of structural variants.

OGM necessitates labeled ultra-high molecular weight (UHMW) DNA, and Bionano offers a diverse range of DNA sample prep kits designed for simple and reliable isolation of UHMW DNA from various sample types. Once DNA isolation is complete, our Direct Label and Stain (DLS) kits can efficiently label DNA for compatibility with the Saphyr system.

With our Generation 2 Kits, featuring robust enhancements and optimizations to the sample preparation OGM workflow, you can achieve sample-to-answer results in just 3 to 4 days! Experience accelerated and streamlined sample preparation, paving the way for enhanced genomic analysis and structural variant detection.

Attain robust isolation and labeling of Ultra-High Molecular Weight (UHMW) DNA, crucial for visualizing large genomic structural variants.

Bionano’s innovative Solution Phase (SP) technology facilitates the isolation of DNA fragments exceeding 1 Megabase pair (Mbp) in length, consistently yielding average fragments surpassing 230 kilobase pairs (kbp).

To contextualize, while short-read sequencing generates reads up to 150 base pairs (bp) in length, even leading high-accuracy long-read sequencing methods offer read lengths limited to approximately 25 kilobases (kb). Bionano’s SP technology surpasses these limitations, enabling the analysis of genomic structural variants with unprecedented detail and accuracy.

Extract DNA from a diverse array of crucial sample types effortlessly with the latest Bionano SP DNA prep kits.

These kits excel at purifying Ultra-High Molecular Weight (UHMW) DNA from tissues, tumors, bone marrow aspirate (BMA), blood, cells, as well as various plant and animal tissues. This versatility makes Optical Genome Mapping (OGM) applicable across a wide spectrum of studies and applications, including oncology, constitutional genetic disease research, bioprocessing, and general scientific inquiry.

Bionano’s SP kits necessitate 1.5 * 10^6 cells (for blood, cell lines, and BMA) or 10 – 30 mg of tissue as input. Employing a lyse, bind, and wash process along with novel paramagnetic disks, these kits enable the isolation of UHMW DNA in approximately four hours. This streamlined workflow ensures efficient extraction of high-quality DNA, empowering researchers across various fields to unlock the mysteries of the genome with ease.

Boost your workflow throughput by integrating the efficiency of automation.

Through a pioneering collaboration with the Hamilton Company, Bionano presents the groundbreaking Long String Star V – the world’s inaugural automated platform tailored for the isolation of Ultra-High Molecular Weight (UHMW) DNA.

The Long String Star V stands as an assay-ready workstation, harmoniously designed to complement Bionano’s G2.LS DNA Isolation kits. With this innovative platform, a single operator can seamlessly extract UHMW DNA from up to 24 samples per day, revolutionizing sample processing efficiency while maintaining high-quality results. Experience unparalleled productivity and precision as you propel your research forward with the Long String Star V automation system.

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Stratys

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Stratys

Elevate the OGM Sample-to-Report Workflow with the Stratys™ System

Embark on a revolutionary journey towards enhanced workflow speed and simplicity by leveraging the power of Optical Genome Mapping (OGM) combined with the cutting-edge Bionano Stratys™ System. With this innovative approach, break free from the limitations of conventional cytogenetics and sequencing techniques, as you delve into the comprehensive detection of all classes of structural variants. Experience a paradigm shift in genetic analysis, where efficiency and precision converge to unlock new realms of understanding within the genome.

*Lower VAF percentages can be achieved when using the Stratys Plus Chip, which enables up to 1200x genome coverage.

STRATYS CHIPS

Experience unparalleled efficiency and tailored performance with STRATYS CHIPS – your gateway to optimized reagents and consumables for diverse applications. Tailor your journey to results with a versatile array of chips meticulously crafted to align with your unique requirements. Within the STRATYS chips, immerse DNA molecules in a precise nanofluidic environment, where they seamlessly linearize across hundreds of thousands of nanochannels. Through advanced imaging, unravel the intricate genomic architecture and uncover subtle structural variations with unparalleled clarity and accuracy.

STRATYS COMPUTE

Maximize workflow efficiency with STRATYS COMPUTE, your solution for streamlined data processing, ensuring a seamless flow of operations.

Data Processing Powerhouse: Powered by NVIDIA RTX GPUs, STRATYS COMPUTE boasts remarkable processing power, enabling significantly faster runtimes and reduced compute costs. Leveraging cutting-edge technology, software releases drive acceleration, enhancing overall performance.

Support a Constant Flow of Data: Benefit from STRATYS COMPUTE’s advanced technology and intelligent processing, facilitating a continuous stream of data from the Stratys instrument. This ensures optimal scalability of your workflow, maintaining productivity at scale.

Best Sensitivity for OGM: Equipped with the latest informatics pipeline for Optical Genome Mapping (OGM) data, STRATYS COMPUTE delivers unparalleled sensitivity for genome-wide detection of all classes of structural variants (SVs) using OGM technology.

Minimal IT Resources Required: Designed for ease of implementation, the STRATYS COMPUTE workstation can be conveniently installed alongside the Stratys instrument without the need for a dedicated data center. This reduces IT overhead and minimizes implementation time, ensuring a hassle-free setup process.

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Saphyr

February 19, 2024/in Bionano, Partners/by Harshita Sharma

PRODUCTS

Saphyr

Reveal genome-wide structural variation with the Saphyr™ optical genome mapping system.

Consistently identify structural variants across all classes with a resolution as low as 500 base pairs (bp) and a variant allele frequency (VAF) as low as 5% utilizing optical genome mapping (OGM) through the Saphyr™ system. Saphyr™ stands as the foremost tool for detecting structural variants, surpassing the capabilities of next-generation sequencing (NGS) methods and traditional cytogenetic approaches, thus capturing genomic variations often overlooked by these technologies.

Achieve broad, unbiased genomic coverage with flexible data collection.

The Saphyr™ system offers adaptable genomic coverage, enabling the identification of heterozygous or infrequent variants present in mosaic samples and heterogeneous tumors.

In just six hours, obtain a comprehensive 100X coverage of a human genome. To uncover deeper and rarer variants, merely prolong the data collection time on Saphyr™ without incurring additional consumable costs. Achieve an impressive 400X coverage within a 24-hour period, facilitating structural variant (SV) detection down to a 5% variant allele frequency (VAF). Extend runtime further to explore variants with even lower VAF levels.

Enjoy seamless integration and workflow efficiency with the Saphyr™ Chip® consumable and Saphyr™ system.

The Saphyr Chips feature hundreds of thousands of highly parallel nanochannels, which efficiently linearize long, labeled DNA molecules, enabling direct imaging of your samples by the Saphyr instrument.

Sample loading onto the Saphyr Chip is swift and straightforward. Easily pipette up to three samples into individual flow cells on the chip. With the capability to load up to two chips onto the Saphyr instrument per run, achieve a maximum throughput of six samples per operation.

Benefit from the Saphyr instrument and chips’ integration of machine learning-based adaptive loading and automatic run optimization. These features ensure hassle-free scanning and optimize throughput speed, allowing for walk-away operation and the fastest achievable throughput for each run.

Guarantee optimal performance through automated health system monitoring accessible remotely.

The Saphyr™ Assure Service offers an optional (opt-in) automated health monitoring feature, which consistently evaluates data quality and instrument functionality. This feature detects potential issues before they impact data quality and performance, enabling Bionano Support to proactively address any concerns and conduct necessary repairs with minimal downtime.

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Franklin

January 30, 2024/in Genoox, Partners/by Harshita Sharma

PRODUCTS

Franklin

Introducing Franklin – a groundbreaking initiative that seamlessly integrates public data sets with real-world evidence, revolutionizing clinical diagnosis, expediting clinical reporting, ensuring consistent classification, all while fostering a thriving community of genomic professionals and upholding data sovereignty and security.

Impacting Lives at the
Point of Care

Your Gateway to the
Actionable Genome

The Power of
Community

Actionable Insights: With Franklin, genomic professionals can redirect their focus from navigating evidence to delving into actionable insights. Our mission is to construct the most extensive and diverse real-world evidence dataset, unlocking answers to any genomic query through the collaborative power of the community, data, and insights.

Franklin’s Community: Who makes up the Franklin community? Our genomic professionals hail from every facet of the medical genetics domain and span the globe. From genetic counselors, expert physicians, and oncologists to variant scientists, bioinformaticians, clinical geneticists, researchers, and pharmacologists, Franklin unites a diverse array of specialists dedicated to advancing genomic knowledge and practice.

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Our team at Decode Science can help connect you with the experts at Genoox, to arrange a customised demo for your group.

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DNBSEQ-E25

January 29, 2024/in MGI, Partners, Sequencing Platforms/by Harshita Sharma

PRODUCTS

DNBSEQ-E25

DNBSEQ-E25 : Sequence Your Samples On-The-Go

Embark on a streamlined sequencing journey from sample to report with the DNBSEQ-E25 sequencer. This compact and standalone system is designed to operate effortlessly inside or outside the lab, providing versatility in its usage. The E25 seamlessly integrates a microfluidic chip, an integrated CMOS detection module, self-luminous dye, and a proprietary computing module. This harmonious combination results in a lightweight and cost-effective instrument that breaks free from location restrictions, allowing you to conduct sequencing processes with ease and efficiency. The DNBSEQ-E25 is your solution for convenient and accessible sequencing wherever you need it.

Plug-And-Play

Experience seamless and hassle-free sequencing with our plug-and-play solution. The DNBSEQ-E25 incorporates an integrated microfluidic sequencing chip with a CMOS detection module underneath each spot. This innovative design minimizes environmental sensitivity, reduces costs, and lightens the weight of the sequencer. The result is a truly plug-and-play system, streamlining the sequencing process and providing you with an efficient and user-friendly solution for your research needs.

Data Analysis Has Never Been Easier

Simplify your data analysis process with the DNBSEQ-E25, where efficiency meets ease. The advanced model, DNBSEQ-E25A, takes it a step further by incorporating an enhanced computing module capable of running data analysis for various applications, including whole-genome sequencing. These sequencing platforms operate as standalone systems, managing the entire workflow from sample to result without the need for a network connection. This not only ensures ease of use but also eliminates the risk of data breaches, providing you with a secure and reliable solution for your sequencing needs.

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MGI Portfolio

DNBSEQ T7+

DNBSEQ-T1+

DNBSEQ-E25

DNBSEQ-G400

DNBSEQ-T7

DNBSEQ-G99

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DNBSEQ-G400

January 29, 2024/in MGI, Partners, Sequencing Platforms/by Harshita Sharma

PRODUCTS

DNBSEQ-G400

DNBSEQ-G400 : Your Day-to-Day Sequencing Solution

Elevate your day-to-day sequencing experience with the DNBSEQ-G400, your comprehensive sequencing solution. This system offers a versatile range of sequencing options, accommodating read lengths of up to SE400/PE300 and supporting two flow cell types. With built-in primary data analysis and optimized optical and biochemical systems, the DNBSEQ-G400 ensures a seamless and efficient sequencing process for your daily research needs. Trust in this innovative solution to deliver reliable and high-quality results, making it an essential tool for your routine sequencing endeavors.

Features

The sequencing platform offers a broad data output range of 55 Gb to 1440 Gb per run, with PE150(FCS) sequencing achieving full capacity in just 37 hours. It supports various read lengths, including SE50, SE100, SE400, PE100, PE150, PE200, and PE300. The platform’s versatility extends to diverse applications, encompassing basic research, clinical research, forensics, and agriculture, making it suitable for a wide range of scientific and investigative endeavors.

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MGI Portfolio

DNBSEQ T7+

DNBSEQ-T1+

DNBSEQ-E25

DNBSEQ-G400

DNBSEQ-T7

DNBSEQ-G99

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DNBSEQ-T7

January 29, 2024/in MGI, Partners, Sequencing Platforms/by Harshita Sharma

Turbocharge Your Sequencing with MGI DNBSEQ-T7

High-throughput sequencing projects often stall when data volume, turnaround time, or workflow scalability become limiting factors — especially in whole genome, deep exome, transcriptome, and epigenome studies. Traditional platforms struggle to keep pace, leading to longer runtimes, bottlenecks between runs, and delayed analysis.

DNBSEQ-T7 solves this by delivering ultra-high-throughput sequencing designed specifically for data-intensive genomics.
Built on DNBSEQ™ Technology, it combines advanced biochemical, fluidic, and optical systems to generate up to 6 terabytes of high-quality sequencing data per day, enabling faster completion of large and parallel sequencing projects.

Designed for population-scale studies and production sequencing, DNBSEQ-T7 allows labs to run multiple workflows simultaneously without compromising data quality or consistency. It fits seamlessly into large genomics programs where speed, scale, and sustained performance are critical.

For genomics core facilities and research institutes running high-volume sequencing operations, DNBSEQ-T7 removes throughput constraints and accelerates time to results—without forcing workflow trade-offs.

But... Why T7?

SPECIFICATIONS

Dimensions & Weight

Dimensions (L × W × H): 1656 mm × 903 mm × 1815 mm
Net Weight: 765 kg

Power

Power Type: 200 V~240 V, 50/60 Hz, 30 A
Rated Power: 3000 VA

Floor Bearing Capacity

Over 650 kg/m²

Operational Environment Requirements

Temperature: 19°C~25°C; fluctuation < 2°C per hour
Relative Humidity: 30% RH ~ 80% RH; non-condensing
Atmospheric Pressure: 80 kPa ~ 106 kPa
Waterproof Rating: IPX0
Altitude: Below 2000 meters

Bandwidth for Network Connection

300 Mb/s: For local storage network uploads

Number of Flow Cells : 1-4

Reads : 5800 M

Read Length

PE100:
1. Data Output: 1 – 4 Tb
2. Run Time: 20 – 22 hr
3. Q30: >85%
PE150:
1. Data Output: 1.5 – 6 Tb
2. Run Time: 24 – 30 hr
3. Q30: >85%

The maximum number of effective reads is based on the sequencing of an internal standard library. Actual output may vary with sample types and library preparation methods.

Run time includes DNB loading, sequencing, and base calling. The percentage of base above Q30 is the average of an internal standard library over the entire run. The actual performance is affected by factors such as sample type, library quality, and insert fragment length.

The DNBSEQ sequencing platforms are for Research Use Only. Not for use in diagnostic procedures.

DNBSEQ-T7 (CE-IVD)

Product Code: 900-000241-00

DNBSEQ-T7RS

Product Code: 900-000242-00

For guidance on integrating T7 into your research, Decode Science can provide personalised support and local assistance. Simply reach out to me.

RESOURCES

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MGI Portfolio

DNBSEQ T7+

DNBSEQ-T1+

DNBSEQ-E25

DNBSEQ-G400

DNBSEQ-T7

DNBSEQ-G99

January 29, 2024/in MGI, Partners, Sequencing Platforms/by Harshita Sharma

PRODUCTS

DNBSEQ-G99

DNBSEQ-G99 : The Ultimate in Sequencing Speed

Introducing the DNBSEQ-G99, the epitome of sequencing speed and efficiency. This groundbreaking sequencer stands as the fastest ever created, offering unparalleled performance in low- to mid-range throughput, making it an exceptional choice for targeted gene and small genome sequencing research. The G99 features a triangular configuration on the patterned array, achieving a higher density of DNA Nanoballs (DNBs) and consequently yielding an impressive data output of up to 48 gigabytes per run.

Equipped with a proprietary high-resolution objective lens and a high-precision temperature control system, the DNBSEQ-G99 sets a new standard for efficiency. With a remarkable run time for PE150 sequencing, completing the process within just 12 hours, this sequencer ensures swift and reliable results. Notably, during PE100 or PE150 sequencing runs, informative preliminary reports are available within the first 2.5 hours, providing researchers with rapid insights into their experiments. The DNBSEQ-G99 redefines sequencing capabilities, offering researchers an unprecedented combination of speed, density, and data output for accelerated and informative sequencing workflows.

Dual Flow Cells for Maximum Flexibility

The DNBSEQ-G99 introduces a remarkable feature—dual flow cells for maximum flexibility. This innovative capability allows the sequencer to run two flow cells independently, providing users with the adaptable option to plug-and-play as needed. This dual-flow cell design enhances versatility and enables researchers to tailor their sequencing experiments to specific requirements, further expanding the utility and flexibility of the DNBSEQ-G99 in various applications.

Get up to 48 Gb per sequencing run

Unlock unparalleled sequencing capabilities with the DNBSEQ-G99 and achieve up to 48 gigabytes of data per sequencing run. This impressive data output sets a new standard in sequencing efficiency, providing researchers with extensive genomic information in a single run. The DNBSEQ-G99 empowers users to generate large volumes of high-quality data, enabling comprehensive insights and accelerating advancements in genomics research.

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MGI Portfolio

DNBSEQ T7+

DNBSEQ-T1+

DNBSEQ-E25

DNBSEQ-G400

DNBSEQ-T7

DNBSEQ-G99

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MGISP-7000

January 29, 2024/in Automated Systems, MGI, Partners, Sample Transfer/by Harshita Sharma

MGI
STP-7000

The STP-7000 is a fully automated sample transfer system built for high-throughput labs that can’t afford errors or downtime. It integrates tube decapping/recapping, barcode recognition, automated liquid handling, and negative-pressure protection into one continuous workflow. The system transfers up to 192 samples from airtight or standard tubes into 96-well plates in just 40 minutes, significantly boosting nucleic acid testing throughput. Dual HEPA filtration, integrated UV sterilization, automatic barcode capture, and ZLIMS connectivity ensure operator safety and end-to-end sample traceability.

One-Stop Sample Preparation and High Productivity

As the official distributor of MGI in Australia and New Zealand, Decode Science is providing local access to STP7000 solutions with region-based technical and application support. Simply talk to me and we can discuss your research needs.

Multiple Applications

The STP-7000 is supplied in a standard configuration supporting 5–30 mL screw-cap tubes, already eliminating up to 8 hours of manual handling. Optional upgrade modules extend compatibility to BD 4 mL, 6 mL, and 10 mL blood collection tubes, as well as 2 mL cryopreservation tubes. The system also enables direct tube-to-tube transfer into 1.5 mL centrifuge tubes, 2 mL cryovials, and 5 mL Roche tubes, with additional custom tube adaptors available to support diverse laboratory workflows.

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Product Specifications

Throughput	192 Samples / 40 mins; one sample in 15 s
Pipetting Method	Based on the principle of air displacement, liquid level detection
Volume Range	2 μL–1000 μL
Accuracy	10 μL: < 5 %; 100 μL: < 2 %; 1000 μL: < 1 %
Coefficient of Variation (CV)	10 μL: < ± 10 %; 100 μL: < ± 5 %; 1000 μL: < ± 2 %
Robot Arm Accuracy	X – Y – Z: ± 0.1 mm
Barcode Scanner	Four 1D scanner sensors
UV Light	36 W
Supply/Exhaust Air Filter	ISO5; HEPA 99.995 % at 0.3 μm; Negative pressure system
Tube Compatibility	Universal fit; excellent fit on 5 mL and 10 mL transport tubes with screw cap
Functions	Integrates decapping, recapping, barcode identification, automated liquid transfer, HEPA filtration, and negative pressure protection

MGI Portfolio

Author Archive for: Harshita

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Entries by Harshita Sharma

Compute Solutions

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Sample Preparation Kits

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Stratys

500 bp

5%

12 Samples

1200x

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Saphyr

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Franklin

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DNBSEQ-E25

Plug-and-Play

Efficient

Hassle-free

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DNBSEQ-G400

Accurate

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Reads Per Run

Samples

Read Lengths

DNBSEQ-T7 (CE-IVD)

DNBSEQ-T7RS

Ebru Boslem

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DNBSEQ-G99

Fast

Flexible

Easy-to-Use

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Fully automated sample prep

High throughput

Scalable automation

Powerful and User-friendly

Chris Wicky

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