Entries by Harshita Sharma

OGM Data Services

PRODUCTS

OGM Data Services

Compute Solutions Bionano

USING OGM IN YOUR RESEARCH

Incorporating Optical Genome Mapping (OGM) into your research opens up a realm of possibilities for detecting genome-wide structural variations with unparalleled sensitivity and unbiased analysis. Unlike sequencing-based technologies and conventional cytogenetic techniques, OGM offers a comprehensive and highly sensitive approach to uncovering structural variations within the genome.

By leveraging our services laboratory, you can embark on projects to analyze samples using OGM. Our expert team will guide you through the process, ensuring accurate and reliable results. Whether you’re exploring genetic anomalies in cancer, investigating constitutional genetic disorders, or studying complex genomic rearrangements, OGM provides a powerful tool for uncovering structural variations with precision and efficiency.

With OGM, you can gain deeper insights into the genomic landscape of your samples, leading to breakthroughs in understanding disease mechanisms, identifying potential therapeutic targets, and advancing personalized medicine initiatives. Join us in harnessing the transformative potential of OGM to drive forward your research and uncover the hidden secrets of the genome.

HOW IT WORKS

During an Optical Genome Mapping (OGM) research project with our services laboratory, you’ll embark on a collaborative journey with our experienced team.

 

Here’s how it works:

  1. Project Initiation: You’ll collaborate with our team to define the scope of your research project. Together, we’ll discuss your research question, objectives, and sample set selection.
  2. Sample Analysis: Once the project scope is defined, our laboratory will perform OGM and initial structural variant analysis on your selected sample set. Using state-of-the-art technology and methodologies, we’ll generate high-quality data to address your research needs.
  3. Collaboration and Communication: Throughout the project, we’ll maintain open communication channels to ensure that your research goals are met. We’ll provide regular updates on the progress of the analysis and seek your input as needed.
  4. Data Delivery: At the conclusion of the project, you’ll receive comprehensive deliverables, including raw molecules data, assemblies, and annotated structural variant (SV) calls. Additionally, we’ll provide training on our proprietary visualization software, empowering you to explore and interpret the results effectively.
  5. Data Integration: Our team will support you in integrating OGM results with other data types, such as sequencing and array data. We’ll facilitate exports to various file formats, including VCF files, enabling seamless comparison and combination of OGM results with other datasets.

Through this collaborative approach, we aim to deliver actionable insights that advance your research objectives and drive scientific discovery. Join us in unlocking the full potential of OGM to uncover the mysteries of the genome and accelerate breakthroughs in your field of study.

COMPARISON ANALYSIS

Structural variants called against GRCh37/hg19 or GRCh38/hg38 will be filtered against a control database or gene list of choice based on the project goals. Dual or trio variant annotation can be run for various applications. These include identifying de novo or inherited variants in germline samples, somatic variants in matched tumor-control samples, and targeted structural variants in edited versus unedited control cell lines. Just indicate the relationship between samples in the intake form.

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Bionano Portfolio

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    Compute Solutions

    PRODUCTS

    Compute Solutions

    Compute Solutions Bionano

    Experience comprehensive solutions for Optical Genome Mapping (OGM) data management and processing with Bionano Compute. Our suite encompasses a full spectrum of hardware, software, and cloud-based solutions, ensuring a seamless workflow from start to finish.

    Bionano Compute offers end-to-end experiment management and bioinformatics processing, empowering researchers with robust tools for efficient data analysis. Additionally, it provides convenient management and monitoring tools tailored for the Saphyr™ and Stratys™ instruments, streamlining operations and enhancing productivity.

    With Bionano Compute, researchers can harness the power of advanced technology to unlock insights from genomic data with unparalleled ease and efficiency.

    The Stratys™ Compute high-performance workstation ensures seamless scalability for your workflow demands.

    Fueled by NVIDIA RTX GPUs, it offers expedited runtimes and reduced compute costs, thanks to its cutting-edge technology. With each software release, expect accelerated performance, enhancing overall efficiency.

    Experience unparalleled sensitivity in detecting all classes of structural variants (SVs) across the genome with the latest informatics pipeline tailored for Optical Genome Mapping (OGM) data.

    Installed alongside the Stratys instrument, the Stratys Compute workstation minimizes IT burdens and implementation time, optimizing your setup for streamlined operations.

    Reduce infrastructure costs and expand your Optical Genome Mapping (OGM) capacity effortlessly with Bionano Compute On Demand.

    This pay-per-use solution, accessible via the Bionano Access web server for Bionano Solve operations, revolutionizes OGM data analysis from the Saphyr™ or Stratys™ instruments without necessitating additional infrastructure. Enjoy the flexibility and scalability your experiments demand with Compute On Demand.

    Key advantages of Compute On Demand include:

    1. Analyze large genomes and numerous samples simultaneously, maximizing throughput and efficiency.
    2. Perform pipeline analysis operations seamlessly, without concerns about server capacity constraints.
    3. Safeguard data integrity with encryption measures, ensuring secure operations and compliance with data protection regulations.
    4. Maintain data center compliance with IPAA, CSA, SOC2, and ITAR regulations, guaranteeing adherence to industry standards and regulations.

    With Bionano Compute On Demand, unlock the full potential of your OGM experiments while optimizing costs and maintaining data security and compliance.

    Experience high-speed, on-site Optical Genome Mapping (OGM) data processing tailored for the Saphyr™ with the Saphyr™ Compute Server.

    This compact solution delivers cluster-like performance at an affordable cost, revolutionizing your data analysis capabilities.

    Key features of the Saphyr™ Compute Server include:

    1. Cluster-like Performance: Enjoy the power of multiple simultaneous analyses and sustained throughput, reducing downtime and accelerating your research.

    2. Rapid Analysis: Perform rare variant analysis and annotation of a human genome in approximately nine hours, enabling swift insights into complex genomic structures.

    3. User-Friendly Interface: Seamlessly integrate the Saphyr™ Compute Server into any network setup with its simple web-based interface, ensuring compatibility and ease of use.

    With the Saphyr™ Compute Server, spend less time waiting for data and more time delving into meaningful results, advancing your research endeavors with unparalleled efficiency and speed.

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      Sample Preparation Kits

      PRODUCTS

      Sample Preparation Kits

      Sample Prep Kits Bionano

      Effortlessly prepare samples for Optical Genome Mapping (OGM) with Bionano’s comprehensive Sample Preparation Solutions, ensuring accurate identification of structural variants.

      OGM necessitates labeled ultra-high molecular weight (UHMW) DNA, and Bionano offers a diverse range of DNA sample prep kits designed for simple and reliable isolation of UHMW DNA from various sample types. Once DNA isolation is complete, our Direct Label and Stain (DLS) kits can efficiently label DNA for compatibility with the Saphyr system.

      With our Generation 2 Kits, featuring robust enhancements and optimizations to the sample preparation OGM workflow, you can achieve sample-to-answer results in just 3 to 4 days! Experience accelerated and streamlined sample preparation, paving the way for enhanced genomic analysis and structural variant detection.

      Attain robust isolation and labeling of Ultra-High Molecular Weight (UHMW) DNA, crucial for visualizing large genomic structural variants.

      Bionano’s innovative Solution Phase (SP) technology facilitates the isolation of DNA fragments exceeding 1 Megabase pair (Mbp) in length, consistently yielding average fragments surpassing 230 kilobase pairs (kbp).

      To contextualize, while short-read sequencing generates reads up to 150 base pairs (bp) in length, even leading high-accuracy long-read sequencing methods offer read lengths limited to approximately 25 kilobases (kb). Bionano’s SP technology surpasses these limitations, enabling the analysis of genomic structural variants with unprecedented detail and accuracy.

      Extract DNA from a diverse array of crucial sample types effortlessly with the latest Bionano SP DNA prep kits.

      These kits excel at purifying Ultra-High Molecular Weight (UHMW) DNA from tissues, tumors, bone marrow aspirate (BMA), blood, cells, as well as various plant and animal tissues. This versatility makes Optical Genome Mapping (OGM) applicable across a wide spectrum of studies and applications, including oncology, constitutional genetic disease research, bioprocessing, and general scientific inquiry.

      Bionano’s SP kits necessitate 1.5 * 10^6 cells (for blood, cell lines, and BMA) or 10 – 30 mg of tissue as input. Employing a lyse, bind, and wash process along with novel paramagnetic disks, these kits enable the isolation of UHMW DNA in approximately four hours. This streamlined workflow ensures efficient extraction of high-quality DNA, empowering researchers across various fields to unlock the mysteries of the genome with ease.

      Boost your workflow throughput by integrating the efficiency of automation.

      Through a pioneering collaboration with the Hamilton Company, Bionano presents the groundbreaking Long String Star V – the world’s inaugural automated platform tailored for the isolation of Ultra-High Molecular Weight (UHMW) DNA.

      The Long String Star V stands as an assay-ready workstation, harmoniously designed to complement Bionano’s G2.LS DNA Isolation kits. With this innovative platform, a single operator can seamlessly extract UHMW DNA from up to 24 samples per day, revolutionizing sample processing efficiency while maintaining high-quality results. Experience unparalleled productivity and precision as you propel your research forward with the Long String Star V automation system.

      The Hamilton Long String Star V

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        Stratys

        PRODUCTS

        Stratys

        Bionano Stratys Product

        Elevate the OGM Sample-to-Report Workflow with the Stratys™ System

        Embark on a revolutionary journey towards enhanced workflow speed and simplicity by leveraging the power of Optical Genome Mapping (OGM) combined with the cutting-edge Bionano Stratys™ System. With this innovative approach, break free from the limitations of conventional cytogenetics and sequencing techniques, as you delve into the comprehensive detection of all classes of structural variants. Experience a paradigm shift in genetic analysis, where efficiency and precision converge to unlock new realms of understanding within the genome.

        500 bp

        Detect SVs starting at
        500 bp

        5%

        VAF at 5% or lower*

        12 Samples

        Scalable throughput

        1200x

        Up to 1200x target effective coverage

        *Lower VAF percentages can be achieved when using the Stratys Plus Chip, which enables up to 1200x genome coverage.

        Stratys Performance

        STRATYS CHIPS

        Experience unparalleled efficiency and tailored performance with STRATYS CHIPS – your gateway to optimized reagents and consumables for diverse applications. Tailor your journey to results with a versatile array of chips meticulously crafted to align with your unique requirements. Within the STRATYS chips, immerse DNA molecules in a precise nanofluidic environment, where they seamlessly linearize across hundreds of thousands of nanochannels. Through advanced imaging, unravel the intricate genomic architecture and uncover subtle structural variations with unparalleled clarity and accuracy.

        STRATYS COMPUTE

        Maximize workflow efficiency with STRATYS COMPUTE, your solution for streamlined data processing, ensuring a seamless flow of operations.

        Data Processing Powerhouse: Powered by NVIDIA RTX GPUs, STRATYS COMPUTE boasts remarkable processing power, enabling significantly faster runtimes and reduced compute costs. Leveraging cutting-edge technology, software releases drive acceleration, enhancing overall performance.

        Support a Constant Flow of Data: Benefit from STRATYS COMPUTE’s advanced technology and intelligent processing, facilitating a continuous stream of data from the Stratys instrument. This ensures optimal scalability of your workflow, maintaining productivity at scale.

        Best Sensitivity for OGM: Equipped with the latest informatics pipeline for Optical Genome Mapping (OGM) data, STRATYS COMPUTE delivers unparalleled sensitivity for genome-wide detection of all classes of structural variants (SVs) using OGM technology.

        Minimal IT Resources Required: Designed for ease of implementation, the STRATYS COMPUTE workstation can be conveniently installed alongside the Stratys instrument without the need for a dedicated data center. This reduces IT overhead and minimizes implementation time, ensuring a hassle-free setup process.

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          Saphyr

          PRODUCTS

          Saphyr

          Saphyr System

          Reveal genome-wide structural variation with the Saphyr™ optical genome mapping system.

          Consistently identify structural variants across all classes with a resolution as low as 500 base pairs (bp) and a variant allele frequency (VAF) as low as 5% utilizing optical genome mapping (OGM) through the Saphyr™ system. Saphyr™ stands as the foremost tool for detecting structural variants, surpassing the capabilities of next-generation sequencing (NGS) methods and traditional cytogenetic approaches, thus capturing genomic variations often overlooked by these technologies.

          Achieve broad, unbiased genomic coverage with flexible data collection.

          The Saphyr™ system offers adaptable genomic coverage, enabling the identification of heterozygous or infrequent variants present in mosaic samples and heterogeneous tumors.

          In just six hours, obtain a comprehensive 100X coverage of a human genome. To uncover deeper and rarer variants, merely prolong the data collection time on Saphyr™ without incurring additional consumable costs. Achieve an impressive 400X coverage within a 24-hour period, facilitating structural variant (SV) detection down to a 5% variant allele frequency (VAF). Extend runtime further to explore variants with even lower VAF levels.

          Enjoy seamless integration and workflow efficiency with the Saphyr™ Chip® consumable and Saphyr™ system.

          The Saphyr Chips feature hundreds of thousands of highly parallel nanochannels, which efficiently linearize long, labeled DNA molecules, enabling direct imaging of your samples by the Saphyr instrument.

          Sample loading onto the Saphyr Chip is swift and straightforward. Easily pipette up to three samples into individual flow cells on the chip. With the capability to load up to two chips onto the Saphyr instrument per run, achieve a maximum throughput of six samples per operation.

          Benefit from the Saphyr instrument and chips’ integration of machine learning-based adaptive loading and automatic run optimization. These features ensure hassle-free scanning and optimize throughput speed, allowing for walk-away operation and the fastest achievable throughput for each run.

          Guarantee optimal performance through automated health system monitoring accessible remotely.

          The Saphyr™ Assure Service offers an optional (opt-in) automated health monitoring feature, which consistently evaluates data quality and instrument functionality. This feature detects potential issues before they impact data quality and performance, enabling Bionano Support to proactively address any concerns and conduct necessary repairs with minimal downtime.

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            Franklin

            PRODUCTS

            Franklin

            Introducing Franklin – a groundbreaking initiative that seamlessly integrates public data sets with real-world evidence, revolutionizing clinical diagnosis, expediting clinical reporting, ensuring consistent classification, all while fostering a thriving community of genomic professionals and upholding data sovereignty and security.

             



            Impacting Lives at the
            Point of Care



            Your Gateway to the
            Actionable Genome



            The Power of
            Community

            Actionable Insights: With Franklin, genomic professionals can redirect their focus from navigating evidence to delving into actionable insights. Our mission is to construct the most extensive and diverse real-world evidence dataset, unlocking answers to any genomic query through the collaborative power of the community, data, and insights.

            Franklin’s Community: Who makes up the Franklin community? Our genomic professionals hail from every facet of the medical genetics domain and span the globe. From genetic counselors, expert physicians, and oncologists to variant scientists, bioinformaticians, clinical geneticists, researchers, and pharmacologists, Franklin unites a diverse array of specialists dedicated to advancing genomic knowledge and practice.

            Franklin dashboard

            Want to try before you buy?

            Our team at Decode Science can help connect you with the experts at Genoox, to arrange a customised demo for your group.

            Let’s Find You an Application That Helps
            Your Research

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              DNBSEQ-E25

              E25: Sequencing on the Go

              Not every sequencing question belongs in a core facility. Whether you’re working at a remote field site, a resource-limited clinic, a teaching lab, or simply need a dedicated benchtop instrument without competing for shared equipment time, the DNBSEQ-E25 puts high-quality sequencing where you need it. Weighing just 15 kg and requiring nothing more than a power source, the E25 integrates microfluidic flow cell technology, CMOS-based detection, and self-luminous dye chemistry into a single compact unit that takes you from loaded sample to FASTQ output — no ancillary hardware, no bioinformatics workstation, no internet connection.

              What sets the E25 apart from other portable or benchtop sequencers is the degree to which the entire workflow is self-contained. The built-in computing module handles base calling and report generation on-board, and the enhanced E25A model extends this to full data analysis pipelines for applications including whole-genome sequencing. There’s no washing required between runs, setup takes roughly 10 minutes, and the system supports both MGI and App-C libraries without primer substitutio

              But... Why E25?

              Truly Portable Sequencing

              Plug it in,
              load your sample,
              and sequence.

              No optical alignment, no external fluidics, no vibration-sensitive components to worry about.

              Integrated Detection, No Optical System Required

              CMOS detection module built directly beneath each spot on the microfluidic sequencing chip.

              Eliminates the environmental sensitivity and maintenance overhead.

              Sample to Report — No External Computing

              Handles sequencing and FASTQ output independently.

              No server rack, no cloud upload, no network dependency — which also means no data breach risk for sensitive or clinical samples.

              Specifications

              Your Data Security is Our Top Priority

              All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.

              Download brochure instantly...


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                Supports MGI and App-C libraries and requires no primer substitutions
                Reads* Read Length** Data Output Run Time*** Q30****
                25 M SE100 2.5 Gb 5 hrs >90%
                25 M PE150 7.5 Gb 20 hrs >80%
                * The maximum number of valid reads is obtained by running a specific standard library. Actual performance may vary depending on sample type and library construction method. ** SE100 consumables can be used for SE50 sequencing; PE150 consumables can be used for PE100 sequencing. Read lengths can be customized in the sequencer user interface. *** Run time includes DNB loading and FASTQ generation. Barcode sequencing time is excluded. **** Q30 and run time are averaged across the entire run using a standard library. Actual performance may vary depending on sample type, library quality, insert size, etc.

                Product Model

                E25, E25A*

                Power, Dimensions & Net Weight

                1. Rated Power: 25V DC, 5A
                2. Dimensions (L×W×H): 348 mm × 312 mm × 257 mm
                3. Net Weight: 15 kg
                 

                Operating Environment Requirements

                1. Temperature: 15℃–30℃
                2. Relative Humidity: 20% RH – 80% RH
                3. Atmospheric Pressure: 70 kPa – 106 kPa
                4. Pollution Level: Level 2

                * For indoor use only.

                Why It Matters to You

                For Infectious Disease & Public Health Surveillance

                Pathogen identification and outbreak tracking shouldn't wait for samples to ship back to a central facility. The E25 enables on-site whole-genome sequencing of bacterial and viral isolates — giving public health teams actionable genomic data in hours rather than days, directly at the point of need.

                For Remote & Field-Based Research

                Ecological genomics, conservation biology, environmental monitoring, agricultural pathogen surveillance — all of these benefit from sequencing data generated close to the source. The E25's compact footprint, tolerance to variable environmental conditions, and independence from network infrastructure make it a practical tool for work outside traditional lab settings.

                For Clinical & Diagnostic Development Labs

                For groups developing or validating sequencing-based assays, the E25 offers a self-contained platform that simplifies compliance considerations. On-board data processing with no network dependency means sensitive patient-derived data never leaves the instrument, reducing IT and security overhead during assay development and pilot studies.

                For Teaching & Training Environments

                Giving students hands-on sequencing experience usually requires access to expensive, shared equipment with strict booking schedules. The E25 is affordable enough, compact enough, and simple enough to operate in a teaching lab context — making it possible to integrate real sequencing runs into graduate coursework and workshops.

                Step 1 — Talk to Us

                Speak with a Decode Science specialist to determine whether the E25 fits your application, throughput needs, and operating environment. We'll help you understand the available configurations (E25 vs. E25A) and consumable options.

                Step 2 — Prepare Your Libraries

                Use your existing MGI-compatible or App-C library preparation workflow. No primer substitutions or protocol modifications are required. The E25 supports SE100 and PE150 read configurations, with customisable read lengths set directly in the instrument interface.

                How You Can Achieve These Results

                Step 3 — Load and Run

                Set up takes approximately 10 minutes. Load your DNB library onto the microfluidic flow cell, insert it into the instrument, and start the run. SE100 runs complete in around 5 hours; PE150 runs in approximately 20 hours.

                Step 4 — Get Your Results

                FASTQ files are generated on-board at the end of each run. With the E25A model, downstream analysis — including alignment and variant calling for WGS applications — is handled directly on the instrument. Transfer data via USB or external drive.

                Ebru Boslem

                ANZ Market Manager - Research Genomics

                Considering portable sequencing for your lab or field site?
                 
                We can advise on applications, library compatibility, and how the E25 fits into your current workflow. Simply reach out to me.

                What our customer says...

                Dr Lyman Ngiam (PhD) Postdoctoral Research Fellow at Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance

                Dr Lyman Ngiam (PhD)

                Postdoctoral Research Fellow at Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance

                "Both E25 and D4 have demonstrated the capability to generate sequencing results within a single day. The prebuilt library preparation protocol and streamlined sequencing workflow make the system highly user-friendly, enabling anyone with piptetting skill to perform sequencing runs with ease.
                The simplified operation has significantly reduced preparation time. Notably, the system’s ability to work with low starting DNA concentrations makes it particularly versatile, allowing sequencing of a wide range of sample matrices without the need to obtain high DNA yields beforehand.
                Overall, it is an efficient and practical platform, essentially a "load-and-go" system."

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                MGI Portfolio

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                  Antibody EngineeringAquacultureCardiovascularCore FacilityCROsCytogeneticsDrug DiscoveryEarly stage biotechEnzyme EngineeringFood SafetyGermlineHorticulture (plant)ImmunologyInfectious DiseaseLivestockmRNA/RNANeuropathologiesNeuroscienceOncologyOncology Pre ClinicalPhysiologyProtein EngineeringRare DiseaseSoil and EnviromentalStructural BiologySynthetic BiologyTherapeuticsOther

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                  DNBSEQ-G400

                  DNBSEQ-G400

                  G400: Seamless, Fast, and Precise Sequencing

                  Most genomics labs don’t run one application — they run many. The DNBSEQ-G400 is designed for exactly this reality. With two independent flow cell slots, two flow cell formats (FCS and FCL), and read configurations spanning SE50 through to PE200 and even SE400, the G400 lets you run different applications simultaneously on the same instrument without compromising on turnaround or data quality. Powered by MGI’s StandardMPS 2.0 reagent chemistry, the platform achieves Q40 accuracy across key read lengths — a level of base-calling precision that reduces error rates and strengthens confidence in variant calls, differential expression, and any downstream analysis where per-base accuracy matters.

                  What makes the G400 particularly practical for mid-scale genomics operations is the balance between throughput and flexibility. The large flow cell (FCL) delivers up to 1,800M reads and 540 Gb per flow cell at PE150, putting whole-genome sequencing, large RNA-seq experiments, and high-depth exome batches comfortably within reach. Meanwhile, the small flow cell (FCS) supports faster, lower-volume runs — ideal for targeted panels, amplicon sequencing, or urgent turnaround samples — without wasting capacity. 

                  Flexible Enough for Every Application on Your List

                  Q40 Data Quality as Standard

                  Across SE50, SE100, PE100, and PE150 read lengths on the FCL flow cell — meaning fewer than 1 in 10,000 bases called incorrectly.

                  Dual Flow Cell, Dual Application Flexibility

                  Pair a high-output FCL run (up to 540 Gb at PE150) with a fast-turnaround FCS run (up to 165 Gb at PE150) on the same instrument, at the same time. No scheduling conflicts, no idle capacity, no need for a second instrument.

                  C. Read Length Versatility from SE50 to SE400

                  Short reads (SE50, SE100) for counting-based applications like RNA-seq and ChIP-seq.

                  Standard paired-end reads (PE100, PE150) for exomes, genomes, and panels.

                  And long single-end reads (SE400) for applications requiring extended coverage of contiguous sequence — no hardware reconfiguration required.

                  D. Production-Ready Throughput in a Manageable Footprint

                  Up to 1,080 Gb total output across both flow cells in a single run cycle

                  At 200 kg and roughly 1 m wide, it's a serious production instrument — but one that fits into a standard lab space without the infrastructure requirements of ultra-high-throughput platforms.

                  Chris Wicky

                  Clinical Genomics Manager - ANZ & Country Manager - NZ

                  Running multiple sequencing applications and need a single platform that handles them all? Our team can walk you through flow cell configurations, throughput planning, and how the G400 fits alongside your existing setup.

                  Why It Matters to You

                  For Genomics Core Facilities

                  Your users submit everything from targeted panels to whole genomes, and they all want results yesterday. The G400’s dual flow cell design lets you batch high-throughput projects on the FCL while running urgent or low-volume jobs on the FCS — simultaneously. Q40 data quality across key read lengths means fewer reruns and higher first-pass success rates, keeping your queue moving and your users satisfied.

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                  For Cancer & Clinical Research Labs

                  Somatic variant detection demands accuracy. Q40-grade base quality reduces false positive variant calls, particularly at low allele frequencies where sequencing errors and true variants are hardest to distinguish. The G400’s flexible read lengths also let you run tumour-normal WGS, RNA-seq for gene expression, and targeted hotspot panels on a single platform — simplifying your instrument fleet and standardising your data quality.

                  For Translational & Pharma Research Groups

                  Drug target validation, biomarker discovery, and companion diagnostic development all require reproducible, high-quality sequencing data across multiple assay types. The G400 supports the breadth of applications these programmes demand — WGS, WES, RNA-seq, methylation, targeted panels — on a single instrument with consistent Q40 performance, reducing the platform-to-platform variability that complicates cross-study comparisons.

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                   

                  For Agricultural & Environmental Genomics

                  Genotyping-by-sequencing, amplicon panels for pathogen surveillance, metagenomic profiling, and small genome assemblies all fit comfortably within the G400’s output range. The SE400 read mode is particularly relevant for applications requiring longer contiguous reads without moving to a long-read platform. For labs processing high sample volumes across diverse project types, the dual flow cell system keeps throughput high while accommodating varied experimental designs.

                  Specifications & resources

                  Download Brochure Instantly!


                    Performance by Read Length
                    Read Length Data Output/Flow Cell Data Quality Q30* Data Quality Q40* Run Time**
                    SE50-FCL 75 Gb ~ 90 Gb >90% >85% ~14 h
                    SE100-FCL 150 Gb ~ 180 Gb >90% >85% ~25 h
                    SE400-FCL 600 Gb ~ 720 Gb >70% / ~109 h
                    PE100-FCL 300 Gb ~ 360 Gb >85% >85% ~35 h / 38 h***
                    PE150-FCL 450 Gb ~ 540 Gb >85% >85% ~50 h / 56 h***
                    PE200-FCL 600 Gb ~ 720 Gb >75% / ~107 h
                    SE100-FCS 55 Gb >85% / ~13 h
                    PE100-FCS 110 Gb >85% / ~22 h / 26 h***
                    PE150-FCS 165 Gb >85% / ~31 h / 37 h***
                    * The percentage of bases above Q30 and Q40 is the average from internal standard libraries across the full run. Actual results may vary depending on sample type, library quality, and insert fragment length. Q40 is only achievable with StandardMPS 2.0 reagents.
                    ** Run time is calculated based on dual-slide mode and includes sample loading, sequencing, base calling, and data processing.
                    *** 35 h, 50 h, 22 h, and 31 h reflect reduced times with the latest system upgrade.

                    MGI Portfolio

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                      Antibody EngineeringAquacultureCardiovascularCore FacilityCROsCytogeneticsDrug DiscoveryEarly stage biotechEnzyme EngineeringFood SafetyGermlineHorticulture (plant)ImmunologyInfectious DiseaseLivestockmRNA/RNANeuropathologiesNeuroscienceOncologyOncology Pre ClinicalPhysiologyProtein EngineeringRare DiseaseSoil and EnviromentalStructural BiologySynthetic BiologyTherapeuticsOther

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                      DNBSEQ-T7

                      Turbocharge Your Sequencing with MGI DNBSEQ-T7

                      High-throughput sequencing projects often stall when data volume, turnaround time, or workflow scalability become limiting factors — especially in whole genome, deep exome, transcriptome, and epigenome studies. Traditional platforms struggle to keep pace, leading to longer runtimes, bottlenecks between runs, and delayed analysis.

                      DNBSEQ-T7 solves this by delivering ultra-high-throughput sequencing designed specifically for data-intensive genomics.
                      Built on DNBSEQ™ Technology, it combines advanced biochemical, fluidic, and optical systems to generate up to 6 terabytes of high-quality sequencing data per day, enabling faster completion of large and parallel sequencing projects.

                      Designed for population-scale studies and production sequencing, DNBSEQ-T7 allows labs to run multiple workflows simultaneously without compromising data quality or consistency. It fits seamlessly into large genomics programs where speed, scale, and sustained performance are critical.

                      For genomics core facilities and research institutes running high-volume sequencing operations, DNBSEQ-T7 removes throughput constraints and accelerates time to results—without forcing workflow trade-offs.

                      But... Why T7?

                      Reads Per Run

                      Up to 24 billion reads per run

                      Samples

                      Processes up to 60 whole human genomes per day

                      Read Lengths

                      PE100, PE150, App-A

                      SPECIFICATIONS

                      Your Data Security is Our Top Priority

                      All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.



                      Dimensions & Weight

                      1. Dimensions (L × W × H): 1656 mm × 903 mm × 1815 mm

                      2. Net Weight: 765 kg

                       

                      Power

                      1. Power Type: 200 V~240 V, 50/60 Hz, 30 A

                      2. Rated Power: 3000 VA

                       

                      Floor Bearing Capacity

                      Over 650 kg/m²

                       

                      Operational Environment Requirements

                      1. Temperature: 19°C~25°C; fluctuation < 2°C per hour

                      2. Relative Humidity: 30% RH ~ 80% RH; non-condensing

                      3. Atmospheric Pressure: 80 kPa ~ 106 kPa

                      4. Waterproof Rating: IPX0

                      5. Altitude: Below 2000 meters

                       

                      Bandwidth for Network Connection

                      300 Mb/s: For local storage network uploads

                      Number of Flow Cells : 1-4

                      Reads : 5800 M

                      Read Length

                      1. PE100:

                        1. Data Output: 1 – 4 Tb

                        2. Run Time: 20 – 22 hr

                        3. Q30: >85%

                      2. PE150:

                        1. Data Output: 1.5 – 6 Tb

                        2. Run Time: 24 – 30 hr

                        3. Q30: >85%

                      The maximum number of effective reads is based on the sequencing of an internal standard library. Actual output may vary with sample types and library preparation methods.

                      Run time includes DNB loading, sequencing, and base calling. The percentage of base above Q30 is the average of an internal standard library over the entire run. The actual performance is affected by factors such as sample type, library quality, and insert fragment length.

                      The DNBSEQ sequencing platforms are for Research Use Only. Not for use in diagnostic procedures.

                      DNBSEQ-T7 (CE-IVD)

                      Product Code: 900-000241-00

                       
                      DNBSEQ-T7RS

                      Product Code: 900-000242-00

                      Ebru Boslem

                      ANZ Market Manager - Research Genomics

                      For guidance on integrating T7 into your research, Decode Science can provide personalised support and local assistance. Simply reach out to me.

                      MGI Portfolio

                      Contact Decode Science Today

                      We only need these information to serve you better. Decode Science respects your privacy and will never spam you with unrelated content.




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                        DNBSEQ-G99

                        G99: Lightning-Fast, High-Precision

                        Speed matters in genomics — and not just for urgent clinical samples. Faster turnaround means tighter experimental iteration, shorter time-to-answer for surveillance workflows, and more efficient use of lab time across every application. The DNBSEQ-G99 is engineered around this principle. Delivering PE150 sequencing with Q40 base quality in approximately 12 hours, it is one of the fastest benchtop sequencers in its throughput class. That speed comes from coordinated advances in biochemistry, optics, fluidics, and temperature control — not from cutting corners on data quality. Q40 accuracy (fewer than 1 in 10,000 miscalled bases) is maintained across key read lengths using MGI’s StandardMPS 2.0 reagents, giving you high-confidence data on the first pass.

                         

                        What gives the G99 its breadth is the three-tier flow cell system. The FCS (40M reads) handles small targeted panels and rapid-turnaround jobs. The FCL (80M reads) covers the mid-range — oncology panels, microbial genomes, RNA-seq, methylation, and more — with read lengths from SE50 through PE300 and even SE400 for forensics and long-amplicon work. And the FCU (200M reads) extends into whole-exome sequencing territory, delivering up to 120 Gb per flow cell at PE150 and supporting batches of 8 or more exomes per run. With dual flow cell slots running independently, you can pair any two of these formats in a single run — matching throughput to demand without wasting capacity or waiting for a full batch.

                        G99 with DecodeScience

                        Q40 Accuracy in 12 Hours — The Benchtop Sequencer Built for Speed, Flexibility, and Clinical-Grade Data

                        PE150 at Q40 in 12 Hours

                        For labs running oncology panels, infectious disease assays, or any workflow where next-day results matter, this means samples loaded in the morning can have FASTQ files ready by the end of the day.

                        Three Flow Cell Formats, One Instrument

                        FCS (40M reads), FCL (80M reads), and FCU (200M reads) — covering applications from small targeted panels through to whole-exome sequencing.

                        Read Lengths from SE50 to SE400 — Including PE300

                        SE50 for NIPT and low-pass WGS. SE100 and PE150 for the bulk of standard applications. PE300 for 16S metagenomics and long-amplicon work, delivering up to 240 Gb per run on dual FCU flow cells. And SE400 for forensic DNA applications and extended-read requirements.

                        Chris Wicky

                        Clinical Genomics Manager - ANZ & Country Manager - NZ

                        Need help matching flow cell format and read length to your application? Our sequencing specialists can model your sample batching, per-sample costs, and turnaround times — reach out and we’ll respond at the earliest.

                        Specifications

                        Your Data Security is Our Top Priority

                        All our sequencing platforms can work as standalone systems from sample to result without any network connection, eliminating the risk of data breaches and ensuring complete data security.

                        Go to Page 9 for detailed specifications.

                        View Brochure Instantly!



                          G99 Specifications

                          * Effective reads is determined using a standard library. Actual output may vary depending on sample type and library preparation method.

                          ** The percentage of bases above Q30 and run time is the average of an internal standard library over the entire run. The actual performance is affected by factors such as sample type, library quality, and insert fragment length. Only StandardMPS 2.0 (SM 2.0) reagents support the generation of Q40 data.

                          *** The sequencing time is the statistical duration for single flow cell sequencing and dual flow cell simultaneous sequencing.

                          ★ The instrument is equipped with SE50 and PE100 sequencing modes, and the existing reagent kits support SE50 and PE100 read length sequencing.

                          Note: APP-D has built-in Illumina’s Truseq, Nextera adapters, and MGI adapter, which supporting mixed testing of Illumina’s Truseq, Nextera adapters, and MGI adapter libraries.

                          Why It Matters to You

                          For Clinical & Diagnostic Genomics Labs

                          Turnaround time is a clinical deliverable, not a convenience metric. PE150 in 12 hours with Q40 accuracy means panels and exomes can be reported within clinically relevant timeframes. The G99's App-D compatibility with Illumina libraries simplifies validation and transition for labs moving from existing platforms, and the optional bioinformatics module (G99A) enables on-board analysis without external compute infrastructure — reducing IT overhead and data security complexity.

                          For Oncology Panel & Precision Medicine Groups

                          Somatic variant calling at low allele frequencies demands both accuracy and depth. Q40 data quality reduces false positive calls that waste follow-up resources, while the G99's flexible batching — from a handful of samples on the FCS to larger cohorts on the FCU — means you're not over-sequencing small batches or under-powering large ones. Methylation-based cancer detection panels are equally well served, with PE150 support at the depths these assays require.

                          For Infectious Disease & Public Health Surveillance

                          Pathogen identification, resistance profiling, metagenomic screening, and 16S community analysis all run on the G99. SE50 and SE100 modes handle rapid pathogen detection with same-day turnaround. PE300 on the FCL or FCU supports full 16S sequencing for microbiome and environmental monitoring. ATOPlex respiratory and COVID-19 panel workflows are directly supported, and the dual flow cell system lets you run surveillance samples alongside research projects without scheduling conflicts.

                          For Research Groups Running Diverse Applications

                          If your lab runs RNA-seq one week, targeted panels the next, and occasionally needs an exome or a small genome, the G99 eliminates the need to juggle multiple instruments or batch dissimilar projects together. Three flow cell options, read lengths from SE50 to SE400, and dual independent flow cell slots mean virtually any standard NGS application fits on this single benchtop platform.

                          Our team is ready to guide you through solutions that match your lab or clinical needs.

                          Contact Decode Science Today

                          We only need these information to serve you better. Decode Science respects your privacy and will never spam you with unrelated content.




                            Antibody EngineeringAquacultureCardiovascularCore FacilityCROsCytogeneticsDrug DiscoveryEarly stage biotechEnzyme EngineeringFood SafetyGermlineHorticulture (plant)ImmunologyInfectious DiseaseLivestockmRNA/RNANeuropathologiesNeuroscienceOncologyOncology Pre ClinicalPhysiologyProtein EngineeringRare DiseaseSoil and EnviromentalStructural BiologySynthetic BiologyTherapeuticsOther

                            You agree to receive communications from Decode Science. View our Privacy Policy