OGM Data Services

PRODUCTS

OGM Data Services

Compute Solutions Bionano

USING OGM IN YOUR RESEARCH


Incorporating Optical Genome Mapping (OGM) into your research opens up a realm of possibilities for detecting genome-wide structural variations with unparalleled sensitivity and unbiased analysis. Unlike sequencing-based technologies and conventional cytogenetic techniques, OGM offers a comprehensive and highly sensitive approach to uncovering structural variations within the genome.

By leveraging our services laboratory, you can embark on projects to analyze samples using OGM. Our expert team will guide you through the process, ensuring accurate and reliable results. Whether you’re exploring genetic anomalies in cancer, investigating constitutional genetic disorders, or studying complex genomic rearrangements, OGM provides a powerful tool for uncovering structural variations with precision and efficiency.

With OGM, you can gain deeper insights into the genomic landscape of your samples, leading to breakthroughs in understanding disease mechanisms, identifying potential therapeutic targets, and advancing personalized medicine initiatives. Join us in harnessing the transformative potential of OGM to drive forward your research and uncover the hidden secrets of the genome.

HOW IT WORKS

During an Optical Genome Mapping (OGM) research project with our services laboratory, you’ll embark on a collaborative journey with our experienced team.

 

Here’s how it works:

  1. Project Initiation: You’ll collaborate with our team to define the scope of your research project. Together, we’ll discuss your research question, objectives, and sample set selection.
  2. Sample Analysis: Once the project scope is defined, our laboratory will perform OGM and initial structural variant analysis on your selected sample set. Using state-of-the-art technology and methodologies, we’ll generate high-quality data to address your research needs.
  3. Collaboration and Communication: Throughout the project, we’ll maintain open communication channels to ensure that your research goals are met. We’ll provide regular updates on the progress of the analysis and seek your input as needed.
  4. Data Delivery: At the conclusion of the project, you’ll receive comprehensive deliverables, including raw molecules data, assemblies, and annotated structural variant (SV) calls. Additionally, we’ll provide training on our proprietary visualization software, empowering you to explore and interpret the results effectively.
  5. Data Integration: Our team will support you in integrating OGM results with other data types, such as sequencing and array data. We’ll facilitate exports to various file formats, including VCF files, enabling seamless comparison and combination of OGM results with other datasets.

Through this collaborative approach, we aim to deliver actionable insights that advance your research objectives and drive scientific discovery. Join us in unlocking the full potential of OGM to uncover the mysteries of the genome and accelerate breakthroughs in your field of study.

COMPARISON ANALYSIS

Structural variants called against GRCh37/hg19 or GRCh38/hg38 will be filtered against a control database or gene list of choice based on the project goals. Dual or trio variant annotation can be run for various applications. These include identifying de novo or inherited variants in germline samples, somatic variants in matched tumor-control samples, and targeted structural variants in edited versus unedited control cell lines. Just indicate the relationship between samples in the intake form.

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    Compute Solutions

    PRODUCTS

    Compute Solutions

    Compute Solutions Bionano

    Experience comprehensive solutions for Optical Genome Mapping (OGM) data management and processing with Bionano Compute. Our suite encompasses a full spectrum of hardware, software, and cloud-based solutions, ensuring a seamless workflow from start to finish.

    Bionano Compute offers end-to-end experiment management and bioinformatics processing, empowering researchers with robust tools for efficient data analysis. Additionally, it provides convenient management and monitoring tools tailored for the Saphyr™ and Stratys™ instruments, streamlining operations and enhancing productivity.

    With Bionano Compute, researchers can harness the power of advanced technology to unlock insights from genomic data with unparalleled ease and efficiency.

    The Stratys™ Compute high-performance workstation ensures seamless scalability for your workflow demands.

    Fueled by NVIDIA RTX GPUs, it offers expedited runtimes and reduced compute costs, thanks to its cutting-edge technology. With each software release, expect accelerated performance, enhancing overall efficiency.

    Experience unparalleled sensitivity in detecting all classes of structural variants (SVs) across the genome with the latest informatics pipeline tailored for Optical Genome Mapping (OGM) data.

    Installed alongside the Stratys instrument, the Stratys Compute workstation minimizes IT burdens and implementation time, optimizing your setup for streamlined operations.

    Reduce infrastructure costs and expand your Optical Genome Mapping (OGM) capacity effortlessly with Bionano Compute On Demand.

    This pay-per-use solution, accessible via the Bionano Access web server for Bionano Solve operations, revolutionizes OGM data analysis from the Saphyr™ or Stratys™ instruments without necessitating additional infrastructure. Enjoy the flexibility and scalability your experiments demand with Compute On Demand.

    Key advantages of Compute On Demand include:

    1. Analyze large genomes and numerous samples simultaneously, maximizing throughput and efficiency.
    2. Perform pipeline analysis operations seamlessly, without concerns about server capacity constraints.
    3. Safeguard data integrity with encryption measures, ensuring secure operations and compliance with data protection regulations.
    4. Maintain data center compliance with IPAA, CSA, SOC2, and ITAR regulations, guaranteeing adherence to industry standards and regulations.

    With Bionano Compute On Demand, unlock the full potential of your OGM experiments while optimizing costs and maintaining data security and compliance.

    Experience high-speed, on-site Optical Genome Mapping (OGM) data processing tailored for the Saphyr™ with the Saphyr™ Compute Server.

    This compact solution delivers cluster-like performance at an affordable cost, revolutionizing your data analysis capabilities.

    Key features of the Saphyr™ Compute Server include:

    1. Cluster-like Performance: Enjoy the power of multiple simultaneous analyses and sustained throughput, reducing downtime and accelerating your research.

    2. Rapid Analysis: Perform rare variant analysis and annotation of a human genome in approximately nine hours, enabling swift insights into complex genomic structures.

    3. User-Friendly Interface: Seamlessly integrate the Saphyr™ Compute Server into any network setup with its simple web-based interface, ensuring compatibility and ease of use.

    With the Saphyr™ Compute Server, spend less time waiting for data and more time delving into meaningful results, advancing your research endeavors with unparalleled efficiency and speed.

    Ready to Order?
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    Bionano Portfolio

    Let’s Find You an Application That Helps Your Research

    Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

      Or give us a call at:

      1300 581 991

      Sample Preparation Kits

      PRODUCTS

      Sample Preparation Kits

      Sample Prep Kits Bionano

      Effortlessly prepare samples for Optical Genome Mapping (OGM) with Bionano’s comprehensive Sample Preparation Solutions, ensuring accurate identification of structural variants.

      OGM necessitates labeled ultra-high molecular weight (UHMW) DNA, and Bionano offers a diverse range of DNA sample prep kits designed for simple and reliable isolation of UHMW DNA from various sample types. Once DNA isolation is complete, our Direct Label and Stain (DLS) kits can efficiently label DNA for compatibility with the Saphyr system.

      With our Generation 2 Kits, featuring robust enhancements and optimizations to the sample preparation OGM workflow, you can achieve sample-to-answer results in just 3 to 4 days! Experience accelerated and streamlined sample preparation, paving the way for enhanced genomic analysis and structural variant detection.

      Attain robust isolation and labeling of Ultra-High Molecular Weight (UHMW) DNA, crucial for visualizing large genomic structural variants.

      Bionano’s innovative Solution Phase (SP) technology facilitates the isolation of DNA fragments exceeding 1 Megabase pair (Mbp) in length, consistently yielding average fragments surpassing 230 kilobase pairs (kbp).

      To contextualize, while short-read sequencing generates reads up to 150 base pairs (bp) in length, even leading high-accuracy long-read sequencing methods offer read lengths limited to approximately 25 kilobases (kb). Bionano’s SP technology surpasses these limitations, enabling the analysis of genomic structural variants with unprecedented detail and accuracy.

      Extract DNA from a diverse array of crucial sample types effortlessly with the latest Bionano SP DNA prep kits.

      These kits excel at purifying Ultra-High Molecular Weight (UHMW) DNA from tissues, tumors, bone marrow aspirate (BMA), blood, cells, as well as various plant and animal tissues. This versatility makes Optical Genome Mapping (OGM) applicable across a wide spectrum of studies and applications, including oncology, constitutional genetic disease research, bioprocessing, and general scientific inquiry.

      Bionano’s SP kits necessitate 1.5 * 10^6 cells (for blood, cell lines, and BMA) or 10 – 30 mg of tissue as input. Employing a lyse, bind, and wash process along with novel paramagnetic disks, these kits enable the isolation of UHMW DNA in approximately four hours. This streamlined workflow ensures efficient extraction of high-quality DNA, empowering researchers across various fields to unlock the mysteries of the genome with ease.

      Boost your workflow throughput by integrating the efficiency of automation.

      Through a pioneering collaboration with the Hamilton Company, Bionano presents the groundbreaking Long String Star V – the world’s inaugural automated platform tailored for the isolation of Ultra-High Molecular Weight (UHMW) DNA.

      The Long String Star V stands as an assay-ready workstation, harmoniously designed to complement Bionano’s G2.LS DNA Isolation kits. With this innovative platform, a single operator can seamlessly extract UHMW DNA from up to 24 samples per day, revolutionizing sample processing efficiency while maintaining high-quality results. Experience unparalleled productivity and precision as you propel your research forward with the Long String Star V automation system.

      The Hamilton Long String Star V
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        Stratys

        PRODUCTS

        Stratys

        Bionano Stratys Product

        Elevate the OGM Sample-to-Report Workflow with the Stratys™ System

        Embark on a revolutionary journey towards enhanced workflow speed and simplicity by leveraging the power of Optical Genome Mapping (OGM) combined with the cutting-edge Bionano Stratys™ System. With this innovative approach, break free from the limitations of conventional cytogenetics and sequencing techniques, as you delve into the comprehensive detection of all classes of structural variants. Experience a paradigm shift in genetic analysis, where efficiency and precision converge to unlock new realms of understanding within the genome.

        500 bp

        Detect SVs starting at 500 bp

        5%

        VAF at 5% or lower*

        12 Samples

        Scalable throughput

        1200x

        Up to 1200x target effective coverage

        *Lower VAF percentages can be achieved when using the Stratys Plus Chip, which enables up to 1200x genome coverage.

        Stratys Performance

        STRATYS CHIPS

        Experience unparalleled efficiency and tailored performance with STRATYS CHIPS – your gateway to optimized reagents and consumables for diverse applications. Tailor your journey to results with a versatile array of chips meticulously crafted to align with your unique requirements. Within the STRATYS chips, immerse DNA molecules in a precise nanofluidic environment, where they seamlessly linearize across hundreds of thousands of nanochannels. Through advanced imaging, unravel the intricate genomic architecture and uncover subtle structural variations with unparalleled clarity and accuracy.

        STRATYS COMPUTE

        Maximize workflow efficiency with STRATYS COMPUTE, your solution for streamlined data processing, ensuring a seamless flow of operations.

        Data Processing Powerhouse: Powered by NVIDIA RTX GPUs, STRATYS COMPUTE boasts remarkable processing power, enabling significantly faster runtimes and reduced compute costs. Leveraging cutting-edge technology, software releases drive acceleration, enhancing overall performance.

        Support a Constant Flow of Data: Benefit from STRATYS COMPUTE’s advanced technology and intelligent processing, facilitating a continuous stream of data from the Stratys instrument. This ensures optimal scalability of your workflow, maintaining productivity at scale.

        Best Sensitivity for OGM: Equipped with the latest informatics pipeline for Optical Genome Mapping (OGM) data, STRATYS COMPUTE delivers unparalleled sensitivity for genome-wide detection of all classes of structural variants (SVs) using OGM technology.

        Minimal IT Resources Required: Designed for ease of implementation, the STRATYS COMPUTE workstation can be conveniently installed alongside the Stratys instrument without the need for a dedicated data center. This reduces IT overhead and minimizes implementation time, ensuring a hassle-free setup process.

        Ready to Order?
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          Saphyr

          PRODUCTS

          Saphyr

          Saphyr System

          Reveal genome-wide structural variation with the Saphyr™ optical genome mapping system.

          Consistently identify structural variants across all classes with a resolution as low as 500 base pairs (bp) and a variant allele frequency (VAF) as low as 5% utilizing optical genome mapping (OGM) through the Saphyr™ system. Saphyr™ stands as the foremost tool for detecting structural variants, surpassing the capabilities of next-generation sequencing (NGS) methods and traditional cytogenetic approaches, thus capturing genomic variations often overlooked by these technologies.

          Achieve broad, unbiased genomic coverage with flexible data collection.

          The Saphyr™ system offers adaptable genomic coverage, enabling the identification of heterozygous or infrequent variants present in mosaic samples and heterogeneous tumors.

          In just six hours, obtain a comprehensive 100X coverage of a human genome. To uncover deeper and rarer variants, merely prolong the data collection time on Saphyr™ without incurring additional consumable costs. Achieve an impressive 400X coverage within a 24-hour period, facilitating structural variant (SV) detection down to a 5% variant allele frequency (VAF). Extend runtime further to explore variants with even lower VAF levels.

          Enjoy seamless integration and workflow efficiency with the Saphyr™ Chip® consumable and Saphyr™ system.

          The Saphyr Chips feature hundreds of thousands of highly parallel nanochannels, which efficiently linearize long, labeled DNA molecules, enabling direct imaging of your samples by the Saphyr instrument.

          Sample loading onto the Saphyr Chip is swift and straightforward. Easily pipette up to three samples into individual flow cells on the chip. With the capability to load up to two chips onto the Saphyr instrument per run, achieve a maximum throughput of six samples per operation.

          Benefit from the Saphyr instrument and chips’ integration of machine learning-based adaptive loading and automatic run optimization. These features ensure hassle-free scanning and optimize throughput speed, allowing for walk-away operation and the fastest achievable throughput for each run.

          Guarantee optimal performance through automated health system monitoring accessible remotely.

          The Saphyr™ Assure Service offers an optional (opt-in) automated health monitoring feature, which consistently evaluates data quality and instrument functionality. This feature detects potential issues before they impact data quality and performance, enabling Bionano Support to proactively address any concerns and conduct necessary repairs with minimal downtime.

          Ready to Order?
          Our team can help you in placing the order. Click below to get a quote and fast ordering.
          Bionano Portfolio

          Let’s Find You an Application That Helps Your Research

          Get a call from your local Decode Science representative to help you find the best fit genomics products for you.

            Or give us a call at:

            1300 581 991