Entries by Harshita Sharma

Modified LongPlex™ Protocol (LongPlex XL)

Modified LongPlex™ Protocol (LongPlex XL)

Unlock with quick sign up!


    This technical note outlines an alternative workflow for generating 10–15 kb HiFi reads from high-quality genomic DNA using the LongPlex Long Fragment Multiplexing Kit. In this approach, LongPlex is used to fragment and barcode samples, and PacBio’s Short Read Eliminator (SRE) is applied to size-select fragments >10 kb before SMRTbell® library preparation.

    LongPlex uses plate-based transposase tagmentation for multiplexed fragmentation and barcoding, removing the need for mechanical shearing and allowing barcoded samples to be pooled before SMRTbell prep. This simplifies the workflow, increases throughput, and lowers library prep costs.

    The standard LongPlex protocol generates 6–9 kb HiFi reads from high- to medium-quality DNA—ideal for microbial and other small-genome projects. However, users working with higher-quality DNA may want longer HiFi reads to maximize gigabase yield on PacBio systems.

    This modified workflow is only suitable for high-quality DNA (Femto Pulse GQN30kb ≥7). Using degraded DNA will result in substantial sample loss during SRE size selection.

    LongPlex™ XL Long Fragment Multiplexing

    Chris Wicky

    Country Manager - NZ

    As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

    Site Directed Mutagenesis

    Mutants Synthesized. Mutagenesis Simplified.

    Make Site-Directed Mutagenesis precise, simple, and affordable with Twist’s Mutagenesis by Synthesis. Traditional site-directed mutagenesis can be time consuming and imprecise. Site directed mutagenesis through synthesis eliminates these complexities, providing you with precisely engineered sequences tailored to your exact specifications. From protein engineering to functional genomics, incorporate precision synthesis of mutants into your workflow and focus on achieving your research goals

    Why it matters to you:

    Precision engineering – 

    site-directed mutagenesis, custom DNA

    Flexible design

    protein engineering, functional genomics

    Fast turnaround

    Express Clonal Genes, rapid synthesis

    Cost-effective

    affordable variants, scalable synthesis

    How to Qualify


    Product: Clonal Genes
    Number of mutation per genes: No Limit
    Mutation type: any number of point mutation,
    deletions, and/or insertions*
    Pricing: Discounts on every variant
    (Please kindly contact your Decode Sales Rep for enquiry)

    How it Works

    Terms and Conditions
    * This promo is only available to customers in the Asia Pacific region (excluding China and Japan). Pricing is subjected to changes.
    * To enjoy the special service of site directed mutagenesis, please quote your previous order number or approach Decode Science support.
    * Each mutation is defined as any combination of bases change within a 10 codon spread over the entire gene.
    * Average turnaround time for Express Clonal Genes is 4 -7 business days. This time will vary based on complexity and length of the sequence. Orders placed outside of the US will incur additional delivery turnaround time. Turnaround time for Clonal Genes is subject to change based on customizations and complexity. Additional specification: 50ng – 2 ug.

    Watch Successful Implementations

    WEBINAR

    Stronger, tighter, and faster: designing new protein functions

    WEBINAR

    Designing Enzymes for the Infinite Recycling and Upcycling of Plastic

    WEBINAR

    Screening Gene Libraries to Rapidly Identify Immune-recognised Virulence Genes.

    Daina Elliott

    Business Development Manager

    As the authorized distributor of Twist Bioscience in Australia and New Zealand, Decode Science makes integrating Twist’s DNA synthesis solutions seamless. We connect your lab with high-throughput, high-fidelity Twist technology, enabling faster, more reliable genomic workflows—with local support and guidance every step of the way.

    Twist Portfolio

    Twist NGS

    NGS

    Raise confidence in variant detection with superior target enrichment solutions

    Twist Oligo Pools

    Oligo Pools

    Precision, uniformity, and flexibility for results you can trust

    Synthetic Controls

    Synthetic RNA and DNA standards for assay development

    Twist Libraries

    Libraries

    Identify more hits and streamline screening with Twist's precise Variant Libraries

    Twist Genes

    Genes

    DNA Your Way: think bigger, expand your scope, and accelerate discovery in genes

    Twist Antibody

    Antibody

    Robust solutions for Antibody Discovery and Development by Twist Bioscience

    Comparison of Evercode™ WT v3 and Chromium™ GEM-X Single Cell 3’ Kit v4 in Mouse Brain Nuclei

    Comparison of Evercode™ WT v3 and Chromium™ GEM-X Single Cell 3’ Kit v4 in Mouse Brain Nuclei

    Unlock with quick sign up!


      Comparison Highlights

      1. Evercode WT v3 delivers superior gene detection in head-to-head sensitivity tests.
      2. Cell type proportions remain consistently represented.
      3. Analysis of differential gene expression shows Evercode WT v3 identifies 2× more genes than competing methods.

      WT-vs-Gem-x-mouse-brain-tech-note-experimental-design-1536x546

      Study Overview
      Two embryonic mouse brains were sagittally dissected and flash-frozen by a third-party vendor.
      One half from each brain was processed by a 10x Genomics certified provider for nuclei isolation and library preparation, while the other halves were processed by Parse Biosciences using their own workflow.
      Sequencing was performed by a third-party, and data analysis was completed using each manufacturer’s respective pipeline.

      Dr. Ebru Boslem

      ANZ Market Manager - Research Genomics

      As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

      Optimized CRISPR/Cas9 Gene Knockout PDF

      Accelerate knockout experiments with XDel’s next-generation CRISPR design.

      EditCo Bio’s XDel technology eliminates the need for guide RNA pre-screening, using a coordinated multi-gRNA design that delivers consistently high on-target editing across immortalized, primary, and iPSC lines. Validated through 768 edited samples and 4,816 NGS libraries, XDel achieves robust knockout efficiency while minimizing off-target effects—saving time and improving reproducibility across diverse cell types.

      Validated performance. Proven precision.
      With a standardized amplicon sequencing QC workflow and high-throughput automation, XDel enables scalable, high-confidence Cas9-mediated editing for both pooled and single-cell clone analysis. Download the full guide to explore the data, workflows, and results behind EditCo Bio’s high-efficiency gene knockout strategy.

      Optimized CRISPR/Cas9 Gene Knockout pdf EditCo Bio

      Unlock to Download Sheet


        Hamza Hassan

        Business Development Manager

        As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

        Excel Sheet: STOmics Validated Tissue List

        STOmics Validated Tissue List

        Our STOmics validated tissue list provides researchers with a comprehensive reference of hundreds of tissue types successfully tested using Stereo-seq, the cutting-edge spatial transcriptomics technology. Each tissue entry includes detailed sample information, experimental parameters, and test results, allowing scientists to make informed decisions before starting their single-cell or spatial transcriptomics experiments. By consulting this list, you can ensure compatibility with your tissue samples and streamline your experimental design.

        The list not only highlights tissue types that have been validated but also provides insights into the experimental conditions that yielded the most reliable results. Researchers can leverage this information to optimize sample preparation, sequencing protocols, and data quality control measures. This reduces trial-and-error, saves valuable time and resources, and ensures reproducibility across studies. It is an essential tool for anyone planning to use Stereo-seq for spatial gene expression profiling.

        In addition, our STOmics validated tissue list supports better planning for large-scale studies and comparative analyses. By providing a centralized reference for tissue performance, it helps guide tissue selection, anticipate potential challenges, and maximize experimental success. Whether you are exploring new tissue types or scaling up existing workflows, this validated tissue list is your key resource for robust, high-quality spatial transcriptomics research.

        STOmics-Validated-Tissue-List

        Unlock to Download Sheet


          Notices:

          The STOmics validated tissue list was generated using standard tissue and sample types, all of which are frozen. Each tissue sample had an area of less than 1 cm² and was sectioned at a thickness of 10 μm. Most experiments were performed using the Stereo-seq Transcriptomics Kit V1.2, with a few using V1.1. Sequencing depth ranged from 1–3 G reads per sample, and data were processed using the Stereo-seq Analysis Workflow (SAW) versions V2.1.0–V5.1.3. Testing was conducted between 2020 and 2022.

          Please note that all test parameters and results are highly dependent on the tissue and sample type. This information should be used as a reference guide to help design and optimize your own experiments, rather than as definitive outcomes for all samples.

          Key parameters included in the list:

          1. MID (K): Bin200_Median_MID in thousands

          2. GENETYPE (K): Bin200_Median_Genetype in thousands

          Dr. Ebru Boslem

          ANZ Market Manager - Research Genomics

          As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

          Data Set: Parse 10 Million Human PBMCs in a Single Experiment

          Scale Single-Cell Research Like Never Before

          Unlock with quick sign up!


            Key Takeaways

            1. Analyze 10 million cells across 1,152 samples in a single experiment

            2. Increase statistical power by profiling more cells per sample

            3. Capture detailed cellular responses to perturbations and drug treatments

            10 Million Human PBMCs in a Single Experiment

            Figure 1: Experimental Design Overview
            Approximately 10 million PBMCs from 12 healthy donors were treated with 90 different cytokines in a single GigaLab experiment, covering 1,092 experimental conditions.

            Cells were thawed, washed, and seeded at 1 million cells per well across 12 plates. After 24-hour cytokine treatment, cells were fixed, barcoded, and processed for whole transcriptome sequencing. Libraries were sequenced on the Ultima Genomics platform, achieving ~31,000 reads per cell, with 62.45% cell retention after barcoding.

            Results?

            After data processing with the Parse Analysis Pipeline v1.4.0, integration, and classification, 9,697,974 cells across 18 immune cell types were identified—including rare populations that are typically missed in smaller experiments. Each condition yielded a median of 7,400 cells, enabling high-resolution analysis of immune responses.

            Differential expression analysis identified how cytokines influenced gene activity across cell types. Many cytokines triggered strong transcriptional responses, with over 50 genes upregulated per treatment.

            Figure 2: Single-Cell UMAP Overview
            9,697,974 PBMCs from 12 donors were integrated with Harmony, clustered using Scanpy, and manually annotated, revealing 18 immune cell types present across all donors and experimental conditions.

            Figure 3: Cytokine-Induced Gene Changes
            A heatmap summarizes the averaged number of genes significantly upregulated (log fold change >0.3, p <0.001) for each cell type and cytokine, highlighting which immune cells respond most strongly to specific cytokine treatments.

            Example tutorial vignettes from Parse Biosciences and Fabian Theis’ lab at Helmoltz-Munich:

            Parse 10M PBMC Cytokines Clustering Tutorial
            Joey Pangallo, Efi Papalexi – Parse Biosciences, Seattle, WA
            Step-by-step example of analyzing 10 million PBMCs treated with cytokines using the Evercode workflow. Covers data loading, preprocessing, Leiden clustering, and generating UMAP plots with Scanpy.


            Parse 10M PBMC Cytokines Clustering Tutorial (Downsampled)
            Joey Pangallo, Efi Papalexi – Parse Biosciences, Seattle, WA
            Same workflow as above, starting with a downsampled dataset of 1 million cells. Ideal for quicker exploration or limited CPU memory setups.


            scCODA Parse 10M PBMC Cytokines
            Artur Szałata, Dominik Klein, Soeren Becker, Fabian Theis – Helmholtz-Munich
            Demonstrates analysis of cell proportion changes across 10 million PBMCs. Shows how using the full dataset improves statistical significance of perturbation effects. Based on scCODA, a Bayesian model for compositional single-cell data analysis (Nat Commun 12, 6876, 2021).


            Parse 10M PBMC Cytokines Dask Workflow
            Artur Szałata, Dominik Klein, Soeren Becker, Fabian Theis – Helmholtz-Munich
            Walks through preprocessing the 10M cell dataset using Dask. Loads data chunk-wise to reduce memory use and demonstrates highly variable gene selection for downstream analysis.


            Dataset License: CC BY-NC 4.0 (non-commercial use). Commercial licensing inquiries: support@parsebiosciences.com

            Dr. Ebru Boslem

            ANZ Market Manager - Research Genomics

            As the official distributor in Australia and New Zealand, Decode Science makes accessing genomics solutions straightforward. Our role is to connect your lab with advanced technologies, ensuring you get the right solution for your sequencing projects—delivered locally with support when you need it.

            DNBSEQ T7+

            MGI T7+ 2025

            T7+: Ultra-Fast, High-Throughput Sequencing Without Compromise

            T7+ is an integrated ultra-high-throughput sequencing platform built for labs that demand speed, accuracy, and scale. Leveraging MGI’s DNBSEQ™ Technology and SM2.0 biochemistry, it delivers over 14Tb of high-quality sequencing data in 24 hours, making large-scale genomics projects—from population studies to clinical pipelines—both feasible and efficient. Its 7-in-1 modular design automates the entire workflow, reducing hands-on time and minimizing potential errors.

            Beyond sheer performance, T7+ is engineered with clinical relevance in mind. Its capacity for up to 35,000 whole-genome sequences annually ensures that your lab can meet high-throughput demands without compromising turnaround times. This efficiency directly translates to faster research insights, improved diagnostic workflows, and smoother integration into daily lab operations, helping you focus on what matters most: accurate, actionable genomic data.



            >14 Tb/24h ultra-fast sequencing



            7-in-1 automation: prep to analysis



            QUAD-Flow Cells: PE150 & PE100 simultaneous



            Q40 >90% high-quality output



            Ergonomic & modular design



            Smart system with diagnostics & self-healing



            Omni-smart hub guides workflows



            Checkpoint resume for uninterrupted runs

            Learn more about how each feature works as you scroll.

            Watch How T7+ Works

            Why It Matters?

            Every hour matters when precision, speed, and reliability determine outcomes. T7+ addresses these challenges by combining ultra-high throughput, rapid turnaround, and intelligent automation, so you can focus on results rather than processes.

            Ultra-Fast Sequencing

            Ultra-Fast Sequencing:

            The proprietary TDI camera and high-density flow cells deliver over 14 Tb of high-quality data in 24 hours, supporting up to 35,000 whole-genome sequences per year. Large-scale projects can now be completed without bottlenecks.

            Seamless Automation

            Seamless Automation:

            The 7-in-1 workflow integrates DNB preparation, loading, sequencing, waste management, data analysis, and compression. This reduces hands-on time, minimizes errors, and produces ready-to-analyze FASTQ files with Q40 >90%.

            Chris Wicky

            Clinical Genomics Manager - ANZ & Country Manager - NZ

            Get a complete overview of T7+ performance, throughput, workflow automation, and configuration options. For guidance on integrating T7+ into your operations, Decode Science can provide personalized support and local assistance.

            Download T7 Plus Brochure

            Unlock with quick sign up!


              Omni Start Hub

              Smart & Intuitive Operation:

              Minimalist design, adjustable screen angles, and the Omni-smart hub guide operations with ease, making daily sequencing as simple as interacting with a smartphone.

              Data compression lossless

              Reliable Data Management:

              Built-in lossless data compression reduces storage and bandwidth needs by up to 5× without compromising accuracy. Intelligent checkpointing ensures sequencing resumes seamlessly after interruptions.

              Empower Multi-Omics

              Versatility for Multi-Omics:

              T7+ supports WGS, spatio-temporal omics, cell-omics, proteomics, epigenomics, transcriptomics, and more, making it adaptable to evolving research and operational needs.

              Related Products

              MGISP-960

              MGISP-960 has validated lots of library kits including WES/WGS/RNA and...

              DNBelab D4 MGI

              DNBelab D series

              Highly integrated technology platform which uniquely uses digital microfluidic...

              DNBSEQ-T7+RS High-Throughput Sequencing Reagent Set

              DNBSEQ-T7+RS Reagent Set

              A sequencing run starts with the hybridization of a DNA anchor, then ...

              FAQs

              What is a TDI Camera?

              A TDI (Time Delay and Integration) camera is a high-performance imaging system used in MGI’s T20×2 ultra-high throughput sequencer to capture fluorescence signals with exceptional sensitivity and speed. Unlike conventional cameras that take static images, a TDI camera continuously scans across the sequencing slide, synchronizing image acquisition with sample movement. This technique integrates multiple exposures of the same area over time, significantly boosting signal strength and reducing noise. In the T20*, the TDI line-scan cameras work alongside a liquid-immersion optical lens and a large field-of-view objective to capture more fluorescence data per unit time with higher resolution. The result is faster, more accurate base identification and greater sequencing throughput — a cornerstone technology enabling MGI’s record-breaking data generation efficiency.

              What is DNBSEQ Technology?

              DNBSEQ is MGI’s proprietary sequencing platform based on DNA Nanoball (DNB) technology. Instead of traditional bridge amplification used by other platforms, DNBSEQ amplifies DNA fragments through rolling circle replication, creating dense, uniform DNA nanoballs that are then arrayed on a patterned flow cell. This approach eliminates amplification errors, reduces duplication rates, and enhances signal precision. Combined with MGI’s two-color fluorescence detection and advanced imaging systems, DNBSEQ delivers high-throughput, low-cost, and highly accurate sequencing results. The platform supports a wide range of applications—from whole genome and single-cell sequencing to metagenomics and oncology research—while offering superior data consistency and scalability compared to conventional NGS systems.

              What is SM 2.0?

              Standard MPS 2.0 (SM 2.0) is MGI’s next-generation sequencing chemistry designed to significantly enhance the accuracy and performance of its DNBSEQ™ platforms. By refining enzyme systems, optimizing fluorescent dyes, and improving data interpretation algorithms, SM 2.0 delivers exceptional sequencing quality—achieving over 85% of bases at Q40, or 99.99% base-calling accuracy. These advancements reduce noise, improve signal clarity, and minimize bias from upstream preparation. As a result, researchers gain higher confidence in detecting low-frequency mutations, SNPs, and InDels across applications such as whole genome sequencing, single-cell studies, and microbiome analysis. In essence, SM 2.0 sets a new industry standard for precision, reliability, and data quality in high-throughput sequencing.

              What happens if there’s a power outage or system interruption during a run?

              T7+ features checkpoint resume technology and proactive fault detection, allowing sequencing to continue without data loss once power or system issues are resolved.

              How much hands-on time is required per sequencing run?

              The 7-in-1 integrated workflow minimizes manual intervention—preparation and monitoring are streamlined, so staff can focus on data analysis rather than instrument operation.

              Can T7+ handle varying sample volumes or project scales?

              Yes. The modular QUAD-Flow Cell system allows independent runs, supporting both small batches and large-scale sequencing without compromising speed or accuracy.

              How easy is it to integrate T7+ into an existing lab workflow?

              The platform is designed to fit seamlessly into existing operations, with smart guidance, automated data processing, and flexible output formats that simplify downstream analysis.

              Ready To Order?

              As the authorised distributor for MGI in Australia and New Zealand, Decode Science makes adopting the T7+ effortless. We connect your lab with MGI’s ultra-high-throughput sequencing technology, helping you implement T7+ for faster, more reliable genomic results—with local support and guidance whenever you need it.

              MGI Portfolio

              Twist Oncology – DNA CGP Panel

              PRODUCTS

              Comprehensive Genomic Profiling for Oncology Research

              The new Twist Oncology - DNA CGP panel offers 562-gene coverage for complete tumour profiling

              Comprehensive Genomic Profiling (CGP) uses next-generation sequencing (NGS) to evaluate multiple clinically relevant biomarkers within a solid tumor. It provides detailed genomic resolution, enabling the detection of single nucleotide variants (SNVs), insertions and deletions (indels), copy number variations (CNVs), select gene fusions, and key cancer genomic signatures such as tumor mutational burden (TMB) and microsatellite instability (MSI).

              By consolidating this information into a single assay, CGP offers a complete view of a tumor’s molecular profile, reducing the need for multiple tumor-specific panels or separate testing methods.

              Why CGP Matters



              Unified Testing Platform

              Combines samples from all tumor types into a single test platform, enabling efficient batching and streamlined workflow.



              Actionable Insights

              Focuses on clinically and research-relevant information, supporting treatment decisions and drug development strategies.



              Cost-Effective Efficiency

              More efficient and economical than whole-exome sequencing (WES) for oncology, lowering resource use while maintaining comprehensive genomic coverage.

              Chris Wicky

              Clinical Genomics Manager - ANZ & Country Manager - NZ

              If you’d like to see how this fits your current setup, I can walk you through integration options or pilot testing. The new Twist Oncology – DNA CGP Panel provides 562-gene coverage for comprehensive tumor profiling.

              Twist Tumor DNA CGP Panel

              Enable improved Tx Selection and enhanced Clinical Research 

              Fixed Panel + Customisation Options

              • 562 genes analyzed for SNVs and hotspot mutations (+39 genes compared to TSO500)

              • Microsatellite instability (MSI) detection across ~50 sites

              • Copy number variation (CNV) analysis for 57 clinically relevant genes

              • Selected fusions and tumor mutational burden (TMB) scoring for complete tumor profiling

              • Add custom biomarkers to differentiate your lab’s testing capabilities

              • Adaptable for specific clinical or research needs

              End-to-End Twist NGS Workflow Compatibility:

              • Library preparations: EF2.0, cfDNA

              • Hybridization solutions with options for software analytics

              • Streamlined workflow for enhanced lab efficiency

              Now available in Australia and New Zealand through Decode Science.

              Example Data Metrics

              Example sequencing QC metrics averaged across data down sampled to 2000x raw coverage (32M 2×150 reads). 4.5 Gb of Data is enough for VAF detections ranging ~2%. Data available upon request.

              Panel target size 2.4 Mb
              Example input 50 ng
              Mean Target Coverage 515x
              On-Target Rate 77%
              Fold-80 Base Penalty 1.32
              Duplication Rate 20%
              Target bases covered >100x 99.5%

              Advantages of Twist Oncology Panel

              CONTENT

              TSO-500 : Content is locked at 523 genes in 2025 and beyond

              Twist CGP : Offers an updated CPG panel of 562 genes with Twist dsDNA probes

              CUSTOMISATION

              TSO-500 : Not Possible

              Twist CGP : Can easily modify content to add genomic features or new biomarkers

              COMPATIBILITY

              TSO-500 : Product is locked into Illumina Platform Ecosystem

              Twist CGP : Twist can enable Illumina short-read platforms and non-Illumina platforms (Ultima, Element, etc.)

              WORKFLOW

              TSO-500 : Requires an overnight capture + 2nd Hybridization Capture

              Twist CGP : Single overnight hybridization capture (Option Trinity on Element)

              COMPETITIVE PRICING

              TSO-500 : High cost per sample for IVD kit pricing

              Twist CGP : Can offer competitive pricing and modular kit options.

              MODULAR PRODUCT

              TSO-500 : Purchase is an all inclusive kit, no option for purchasing components

              Twist CGP : Twist can sell modules, or custom configurations through OEM services

              Customer Testimonial

              "At LifeStrands Genomics Australia, we rely heavily on Twist’s NGS probes and reagents across nearly all our assays... Twist’s probe design flexibility and scalability have allowed us to tailor both DNA and RNA panels that suit a wide range of solid tumours without compromising sensitivity or turnaround times. We view Twist not just as a vendor, but as a strategic partner in advancing precision oncology."
              Dr. Vivek Rathi, MD MSc FRCPA
              Medical Director LifeStrands Genomics Australia (Genoox User)

              Contact Decode Science Today

              We only need these information to serve you better. Decode Science respects your privacy and will never spam you with unrelated content.




                Antibody EngineeringAquacultureCardiovascularCore FacilityCROsCytogeneticsDrug DiscoveryEarly stage biotechEnzyme EngineeringFood SafetyGermlineHorticulture (plant)ImmunologyInfectious DiseaseLivestockmRNA/RNANeuropathologiesNeuroscienceOncologyOncology Pre ClinicalPhysiologyProtein EngineeringRare DiseaseSoil and EnviromentalStructural BiologySynthetic BiologyTherapeuticsOther

                You agree to receive communications from Decode Science. View our Privacy Policy

                DNBSEQ-T1+

                Accelerate high-throughput genomic testing with DNBSEQ-T1+

                The DNBSEQ-T1+ is one of the fastest T-level benchtop sequencers available globally—built on MGI’s proven DNBSEQ™ technology for accuracy, scalability, and reliability. Designed for clinical and translational genomics labs, the T1+ supports dual flow cell operation, delivering up to 1.2 terabases (Tb) of sequencing data within 24 hours (600 Gb per flow cell).

                For laboratories managing time-sensitive or high-volume projects, this means faster turnaround, improved workflow efficiency, and reduced dependence on external bioinformatics infrastructure. The optional integrated bioinformatics module enables automated secondary analysis immediately after sequencing, helping clinicians and molecular pathologists move from raw data to interpretable results without delay.

                In practice, DNBSEQ-T1+ helps streamline comprehensive genomic profiling (CGP), oncology testing, and clinical research pipelines—supporting both diagnostic accuracy and operational consistency across runs.



                High-Speed, High-Throughput Sequencing

                Generate up to 1.2 Tb of data in a single run with dual flow cell operation.

                Choose from FCL, FCM, or FCS flow cells to match your throughput needs—from small clinical batches to large oncology cohorts.

                Maintain >93% Q30 and >90% Q40 base quality across read lengths up to PE150.

                Complete full runs in as little as 7–24 hours, supporting faster reporting and clinical turnaround.



                Versatile Applications Across Clinical Genomics

                Flexible read lengths (SE50–PE300) suit NIPT, RNA-Seq, oncology panels, WES, WGS, and methylation studies.

                Supports coverage depth from 1 Gb to 120 Gb per sample, enabling both targeted assays and whole-genome workflows.

                Ideal for translational and precision medicine—from pathogen detection to tumour profiling.



                Integrated DNB Make & Load Technology

                DNB M&L (Make & Load) module automates DNB preparation and loading directly within the sequencer.

                Delivers consistent, contamination-free results with minimal hands-on time.

                Each flow cell operates independently, supporting different read lengths or applications in parallel.

                Enables an end-to-end “Make–Sequence–Analyse” workflow that saves time and reduces error.



                Smart Configurations and Automated Analysis

                Available in two setups: DNBSEQ-T1+ RS (flexible throughput) and T1+ ARS (with built-in bioinformatics).

                The ARS configuration automatically triggers advanced data analysis post-run, streamlining bioinformatics pipelines.

                Simplifies data interpretation for clinicians and molecular pathologists, improving workflow efficiency and diagnostic accuracy.

                Chris Wicky

                Clinical Genomics Manager - ANZ & Country Manager - NZ

                Download the DNBSEQ-T1+ brochure for a complete overview of performance metrics, application data, and configuration options. For guidance on how this platform fits your lab’s workflow, Decode Science can walk you through integration and local support options.

                View Brochure Instantly!


                  Watch How T1+ Works

                  Related Products

                  MGISP-100

                  Integrated 8 channel pipettes, it processes samples in batches, eliminates...

                  DNBelab D4 MGI

                  DNBelab D series

                  Highly integrated technology platform which uniquely uses digital microfluidic...

                  DNBSEQ-T1+RS High-throughput Sequencing Reagent Set

                  DNBSEQ-T1+RS Reagent Set

                  Supporting oncology panel, WGS, WES, WGBS, multi-omics sequencing and...

                  FAQs

                  How can the DNBSEQ-T1+ support my existing oncology or CGP workflows?

                  The T1+ integrates seamlessly into oncology and comprehensive genomic profiling (CGP) pipelines, providing the depth and coverage needed for both solid tumour and liquid biopsy applications. With PE150 read lengths and up to 1.2 Tb per run, it supports multi-sample batching without compromising turnaround time.

                  What data quality can I expect for clinical reporting?

                  Across all flow cell types, >93% of bases exceed Q30 and >90% exceed Q40, ensuring high-confidence variant detection for SNVs, indels, CNVs, and fusions. This level of consistency reduces the need for re-runs and strengthens the reliability of reported results.

                  How fast can I expect sequencing results for patient samples?

                  Depending on the mode, runs complete within 7–24 hours, with automated secondary analysis available immediately post-run on the T1+ ARS configuration. This supports faster clinical reporting and improved patient turnaround.

                  Does the DNBSEQ-T1+ simplify lab workflows or require extra setup?

                  The DNB Make & Load module automates DNB preparation within the sequencer, reducing manual steps, contamination risk, and hands-on time. Most labs can run end-to-end sequencing with minimal intervention after library prep.

                  Can I run different assays on the same instrument?

                  Yes. Each flow cell operates independently, allowing different read lengths or applications—for example, running oncology panels alongside RNA-Seq or WES on the same instrument without downtime.

                  Ready To Order?

                  As the authorised distributor for MGI in Australia and New Zealand, Decode Science makes adopting the DNBSEQ-T1+ effortless. We bridge your lab with MGI’s high-throughput sequencing technology, helping you implement the T1+ for faster, more reliable genomic insights—supported locally whenever you need it.

                  MGI Portfolio

                  High Throughput Antibody Production

                  PRODUCTS

                  High Throughput Antibody Production

                  Introducing CHO and HEK293 Antibody Production

                  Twist Bioscience helps researchers speed up antibody discovery with Express Antibody Production using CHO and HEK293 expression systems. Our high-throughput antibody production platform can generate anywhere from dozens to thousands of antibodies, enabling efficient antibody screening for binding specificity and biophysical properties.

                  By leveraging Twist’s end-to-end gene-to-protein workflow, you can eliminate common antibody production bottlenecks—saving valuable time and research costs. Starting with Twist Express Genes ensures faster production times and antibodies built entirely from your custom gene sequences.

                  Key Features

                  CHO Express Antibodies

                  1. From 13 business days*
                  2. 1 mL and 8 mL scales available
                  3. Average Yields = 640 ug

                  HEK293 Express Antibodies

                  1. From 10 business days*
                  2. 1 mL and 8 mL scales available
                  3. Average = Yields 760 ug

                  Why Twist for Antibody Production?



                  Customization

                  Design antibodies with optimal binding affinity, specificity, and reduced immunogenicity.



                  Speed & Efficiency

                  Rapid, sequence-perfect DNA synthesis accelerates your antibody development timeline.



                  Scalable Production

                  From small-scale studies to large-scale drug discovery, scale antibody production with ease.



                  Cutting-Edge Technology

                  Access the latest gene synthesis innovations without high costs.



                  Expert Support

                  Get 24/7 guidance from antibody design to submission.

                  You design it. We build it.

                  IgG Workflow - Antibody Production

                  What Scientists Have to Say

                  Wyatt McDonnell

                  CEO & Founding Scientist • Infinnimune

                  Using Twist’s solutions saves us hundreds of thousands of dollars annually in labor costs. The cost efficiency of Twist Express Antibodies allows us to test four times as many antibodies each year as we otherwise could.

                  Dr. Ahuva Nissim

                  Professor in Antibody and Therapeutic Engineering • Queen Mary University of London

                  Working with Twist…was a great experience…[Twist’s] support was amazing. We have performed the first validation selections which looks promising…

                  Pierre Martineau

                  Deputy Director, Cancer Research Institute of Montpellier • Founder and Scientific Advisor, iMAb

                  We have performed the first selections using the Fab and scFv libraries. No problem in both cases, we got clones and some look really promising.

                  Ready To Order?

                  Our team can help you in placing the order. Click below to get a quote and fast ordering.

                  Have a question?

                  Get a call from your local Decode Science representative to help you find the best fit genomics products for you.


                    Or give us a call at:

                    1300 581 991