DNBSEQ is MGI’s proprietary sequencing platform based on DNA Nanoball (DNB) technology. Instead of traditional bridge amplification used by other platforms, DNBSEQ amplifies DNA fragments through rolling circle replication, creating dense, uniform DNA nanoballs that are then arrayed on a patterned flow cell. This approach eliminates amplification errors, reduces duplication rates, and enhances signal precision. Combined with MGI’s two-color fluorescence detection and advanced imaging systems, DNBSEQ delivers high-throughput, low-cost, and highly accurate sequencing results. The platform supports a wide range of applications—from whole genome and single-cell sequencing to metagenomics and oncology research—while offering superior data consistency and scalability compared to conventional NGS systems.

Standard MPS 2.0 (SM 2.0) is MGI’s next-generation sequencing chemistry designed to significantly enhance the accuracy and performance of its DNBSEQ™ platforms. By refining enzyme systems, optimizing fluorescent dyes, and improving data interpretation algorithms, SM 2.0 delivers exceptional sequencing quality—achieving over 85% of bases at Q40, or 99.99% base-calling accuracy. These advancements reduce noise, improve signal clarity, and minimize bias from upstream preparation. As a result, researchers gain higher confidence in detecting low-frequency mutations, SNPs, and InDels across applications such as whole genome sequencing, single-cell studies, and microbiome analysis. In essence, SM 2.0 sets a new industry standard for precision, reliability, and data quality in high-throughput sequencing.