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Knockout CD8+ & CD4+ T Cells

Advanced CRISPR Knock-Ins for iPSC Research

EditCo delivers efficient gene editing with guaranteed >80% efficiency in human primary cells, achieving >90% in many cases, using a smart multi-guide design and a 7-day protocol for results in 2 weeks or faster. Their Primary Cell KO Pools produce functionally consistent cell populations, ideal for drug discovery or biological modeling, while maintaining high viability and functionality. Researchers can use EditCo-supplied cells or their own CD8+/CD4+ T cells, ensuring flexibility and reliability. By minimizing failed experiments and false negatives, EditCo saves time and resources, offering 1M-cell EC Pools for high-quality, rapid, and dependable gene editing.

Image: High editing efficiency across multiple donors.

Image: EditCo KO CD8+ T cell pools can be thawed and expanded for weeks, with or without TCR stimulation.

Next-Level Edited CD8+ T Cells – Powerful, Stable, and Ready for Action

Take your research further with precision-engineered CD8+ T cells that combine high editing efficiency, long-term stability, and exceptional functionality. Designed to maintain their knockout integrity, expand effortlessly post-thaw, and deliver strong antigen-specific responses, these cells are built for performance. Whether you’re exploring immune responses or advancing cell therapy, these edited T cell pools provide the reliability and power you need.

🔬 Unmatched Editing Precision – Achieve over 90% knockout efficiency across multiple donors, maintaining stability before and after cryopreservation.

🧬 Thrives & Expands with Ease – These cells stay healthy and proliferate for weeks, with or without stimulation, ensuring flexibility in your experiments.

⚡ Optimized for Real-World Function – A single round of activation preserves normal function, preventing overstimulation and exhaustion.

🎯 Potent, Targeted Cytotoxicity – Strong antigen-specific activation, with robust CD107a expression, ensures effective tumor-killing potential.

Power up your research with CD8+ T cells engineered to perform when it matters most.

CD4+ T Cells - Stability and Functionality Post-Editing

The editing of CD4+ T cells has shown high efficiency and stability, with a robust ability to maintain functionality after the editing process. The efficiency of the CD4+ T cell editing was determined through ICE analysis, with results demonstrating high editing efficacy across multiple loci while ensuring cell viability during the freezing stage. Post-editing, the cells can be thawed and expanded without loss of functionality or editing efficiency. Cytokine production in edited T cells, including IFNg, IL2, and TNFa, indicates that the editing process does not negatively impact the cells’ ability to produce essential cytokines upon stimulation. These edited pools also show high viability, making them suitable for further downstream assays.

– High editing efficiency of CD4+ T cells determined by ICE analysis.
– No reduction in cell viability after freezing, as indicated by flow cytometry
– Successful expansion and thawing of edited cells without affecting functionality
– Edited cells exhibit high levels of cytokine production (IFNg, IL2, TNFa) post-stimulation
– High viability and expansion potential, with >90% viability after 14 days in culture
– Statistical analysis shows significant cytokine differences between edited and mock cells

Image: Editing Efficiency and Viability for CD4+ T cell pools.

Image: Editing Efficiency leads to protein depletion as shown by flow cytometry

Image: CD4+ pool stability after thaw.

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