Combinatorial Variant Libraries
Twist’s Precision Variant Library Technology stands out as a groundbreaking approach for focused screening in protein engineering. Powered by Twist’s massively parallel silicon-based DNA synthesis platform, this technology delivers highly uniform and accurate oligos, with an impressive 90% of oligos represented within <2.5x of the mean. Additionally, it boasts an industry-leading low error rate of 1:2,000 nt.
The combination of this cutting-edge synthesis platform with Twist’s well-established molecular biology expertise allows the creation of highly diverse gene mutant libraries. These libraries exhibit excellent variant representation and offer highly specific user-defined compositions, free from unwanted bias or motifs. With precise control over codon usage, amino acid distribution, and length variation, Twist’s library technology enables comprehensive exploration of the variant sequence space. The key benefits include high diversity precision, verified quality through rigorous quality control and NGS verification, and unmatched flexibility in designing sequences, domains, and combinations. This technology outperforms alternatives like TRIM and the degenerate approach, providing researchers with a superior tool for efficient and tailored protein engineering studies.
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