PRODUCTS
Twist Bioscience’s custom target enrichment panels are designed using a silicon-based DNA synthesis platform that produces highly accurate, reliable probes for next-generation sequencing (NGS). These panels can be tailored to suit a wide variety of applications, from small and highly focused panels targeting specific regions to large and complex designs that span broad genomic areas, making them suitable for almost any sequencing project. The combination of advanced design algorithms, proprietary synthesis processes, and a streamlined production pipeline ensures that each panel delivers uniform coverage, reduced off-target effects, and consistent, high-quality performance across sequencing platforms.
Another advantage of Twist’s approach is the flexibility it provides. Researchers can expand existing panels, update or enhance them with new content, or even combine multiple designs into blended panels to support evolving project needs. Turnaround times are fast, and the resulting panels are built to maintain accuracy and reproducibility, ensuring dependable results even in demanding research environments.
Twist’s double-stranded DNA probes undergo NGS-based quality control to ensure balanced representation and minimise dropout
Easily combine two or more panels into a single design, either in your own lab or through Twist’s streamlined blending service.
Submit specifications online and benefit from Twist’s advanced design algorithms that optimize every panel for accuracy and efficiency.
From 100 probes to one million, Twist custom panels can be tailored to projects of any size while maintaining consistency and precision.
Clinical Genomics Manager - ANZ & Country Manager - NZ
DNA
Twist Bioscience’s custom DNA target enrichment panels provide advanced solutions for a variety of sequencing applications. Using proprietary strategies such as probe shifter technology, these panels deliver precise, consistent coverage and high-performance results tailored to specific biological targets.
RNA
Twist Bioscience’s RNA custom target enrichment panels are designed to capture and enrich cDNA libraries for next-generation sequencing (NGS). Using innovative strategies such as exon-aware probe placement, these panels provide precise, high-performance coverage to maximize transcriptional insights from your RNA sequencing experiments.
Methylation
Twist Bioscience’s methylation target enrichment panels are designed to capture libraries prepared to reveal DNA methylation patterns. Using a unique design approach with four probe species per target—fully methylated and unmethylated, sense and antisense—these panels deliver uniform coverage while preserving accurate methylation signatures for reliable NGS analysis.
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Custom panels typically use probes that are 120 base pairs (bp) long. Twist also offers alternative lengths—such as 80 bp or 100 bp—depending on your experimental needs, but all probes within a single panel are uniform in length.
Yes. Twist custom panels can be designed for a variety of targets, including gene fusions, single nucleotide polymorphisms (SNPs), viruses, microsatellite instabilities (MSIs), structural variants, copy number variants (CNVs), and insertion/deletion events (InDels).
Yes. Twist offers custom panels specifically for targeted methylation sequencing, optimized to capture methylation patterns with high accuracy.
Yes, all Twist target enrichment probes are double-stranded DNA, ensuring stable hybridization and reliable performance.
Twist performs NGS-based quality control by sequencing the probes to verify their representation within the pool, ensuring consistent and uniform performance across the panel.
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