Twist Alliance Long Read Sequencing Panels combine industry-leading target enrichment chemistry with the power of long read platforms. Capture the genomic regions that matter — including medically complex, difficult-to-map genes — with superior uniformity, cost efficiency, and scalable throughput.
🏅 Compatible with Oxford Nanopore Technologies (ONT) | PacBio
Short read sequencing leaves critical genomic regions in the dark — incomplete gene assemblies, unresolved haplotypes, and missed structural variants. Twist Alliance Long Read Sequencing Panels solve this by pairing optimised probe-based target enrichment with long read sequencing platforms, enabling researchers to study complex genes with high uniformity and no coverage gaps.
Two pre-designed panels are available to address the highest-impact clinical and research applications:
Both panels are compatible with Oxford Nanopore Technologies (ONT) and PacBio platforms, and are backed by protocols optimised specifically for long fragment enrichment.
Probes are specifically optimised for long fragment capture — not retrofitted from short read designs. Achieve high on-target uniformity and consistent sequencing efficiency, even across repetitive or GC-extreme regions.
Purpose-built probe designs ensure balanced coverage across difficult-to-sequence and difficult-to-map regions. Full-gene phasing is achieved for genes like GBA, with no coverage gaps — even in regions historically inaccessible by short read approaches.
Protocols are optimised for long fragment enrichment and high-throughput sequencing. Pack more samples into a single run and extend your study across large patient cohorts — without sacrificing data quality or coverage depth.
Achieve high accuracy variant calling for SNPs, SVs, and indels. Unambiguous haplotype resolution and long-range phasing enable confident interpretation — including accurate star allele calling at CYP2D6 and complete GBA gene analysis.
Many of the most clinically significant genes in the human genome are also among the hardest to sequence. Segmental duplications, pseudogenes, and high homology regions make short read sequencing incomplete or unreliable. The Dark Genes Panel is the purpose-built solution.
Key specifications:
Targets 389 genes across 20 Mb
Key targets include GBA, SMN1/2, CYP2D6, and other medically important dark genes
Full-gene phasing and no coverage gap in the GBA gene
Enables sequencing of genes that are difficult or impossible to fully sequence with short read technology
Clinical Genomics Manager - ANZ & Country Manager - NZ
As the official distributor of Twist Bioscience in Australia and New Zealand, Decode Science is providing local access to these panel solutions with region-based technical and application support. Simply talk to me and we can discuss your research needs.
Drug metabolism varies significantly between individuals — often due to complex gene variants and star alleles in pharmacogenomics (PGx) genes. The Long-Read PGx Panel delivers the resolution needed for confident, clinically actionable PGx interpretation.
Key specifications:
Targets 49 pharmaco-genomics genes across 2 Mb
Key targets include CYP2D6, HLA-A, HLA-B — highly polymorphic and critical to therapeutic decision-making
Accurate star allele calling at CYP2D6
Supports precision medicine, oncology, and population-level PGx studies
Twist Alliance Long Read Sequencing Panels are designed for researchers working at the intersection of genomics, clinical science, and translational medicine. Relevant applications include:
Contact Decode Science | support@decodescience.com.au | 1300 581 991
All Twist Alliance Long Read Sequencing Panels are available in 2, 12, and 96 reaction kit formats to support pilot studies through to large-scale cohort sequencing.
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