Twist Bioscience Variant Libraries are highly diverse, precisely designed DNA libraries that enable you to uncover exactly the genetic variants you need — no compromises, no unwanted sequences. Using our proprietary silicon-based DNA synthesis platform, we generate fully-customized oligo pools and build variant libraries with thousands to billions of unique sequences. Every library is NGS-verified, so what you design is exactly what you get.
Whether you’re working on antibody optimization, enzyme screening, or synthetic biology applications, Twist’s libraries help accelerate your workflow, improve reproducibility, and ensure your experiments are grounded in reliable, high-fidelity genetic material. Our platform removes the uncertainty in library construction, enabling you to focus on discovery, therapeutic development, and clinical research rather than troubleshooting synthesis errors.
Design exactly what you need with user-defined variant libraries. From site-saturation to combinatorial libraries, every sequence is digitally designed and synthesized with high fidelity — no unwanted stop codons or sequence bias.
Access billions of unique variants within a single domain. Our high-complexity libraries allow for deeper exploration of genetic space, enhancing discovery in antibody engineering, enzyme screening, and synthetic biology.
Every library undergoes next-generation sequencing verification, ensuring that what you order is exactly what you receive. Reliable libraries mean faster experiments, higher reproducibility, and reduced troubleshooting.
Simplify your research with our intuitive online ordering platform. Upload sequences, get instant synthesis feasibility, view real-time quotes, and track your order from production to delivery — all while keeping your proprietary data secure.
Twist’s proprietary oligo synthesis technology offers a completely unique approach to library creation. Using our silicon-based platform, we generate high-quality oligo pools that are then assembled into fully-customized, user-defined variant libraries on a single chip. Whether you need thousands or billions of variants, what you design is exactly what you receive, giving you confidence and reproducibility in every experiment.
Twist has developed high-fidelity methods for precisely splicing large oligonucleotide pools, with variations in composition and length, to create NGS-verified combinatorial diversity of up to 10¹⁰ unique variants in a single domain. Every variant is designed in silico and pre-screened, eliminating unwanted sequence bias, premature stop codons, and other undesired motifs — so your library is as precise as your research requires.
In research, every minute counts — and every experiment depends on reliable, high-fidelity DNA libraries. Twist Variant Libraries reduce uncertainty in library construction, meaning you can focus on what really matters: discovery, patient care, and advancing therapeutics.
Accelerate your workflow: Reduce trial-and-error in library creation and spend more time on meaningful experiments.
Improve reproducibility: NGS-verified libraries ensure that what you design is exactly what you get, boosting confidence in your results.
Enhance clinical relevance: High-diversity, precise variant libraries enable better antibody engineering, enzyme screening, and synthetic biology applications — all directly supporting translational research and diagnostics.
Streamline daily routine: Intuitive ordering, real-time quotes, and progress tracking save you administrative time while maintaining security of your proprietary sequences.
Business Development Manager
As the official Twist Bioscience distributor for Australia and New Zealand, Decode Science makes it easy for researchers to access high-quality, scalable DNA synthesis solutions. By connecting local laboratories with Twist’s silicon-based synthesis platform, we ensure you can design, order, and receive variant libraries and oligo pools with precision, reliability, and dedicated local support — so your genomics research keeps moving forward with confidence.
High-Quality Data
Compared to other technologies, Twist libraries show less than 1% deviation from designed amino acid frequencies, allowing scientists to precisely design and customize libraries for comprehensive variant space analysis.
Superior Libraries
Using single-base control and in-silico design, Twist constructs fully-customized, high-diversity libraries without unwanted motifs that could confound your screening. Variants are present at user-defined ratios, ensuring your library reflects exactly what you planned.
ONGOING PROMOTION FOR YOU >
Make Site-Directed Mutagenesis precise, simple, and affordable with Twist’s Mutagenesis by Synthesis. Traditional mutagenesis can be slow and error-prone — our approach eliminates complexity, delivering exactly the sequences you design, whether it’s point mutations, insertions, or deletions.
Why it matters to you:
Precision engineering –
site-directed mutagenesis, custom DNA
Flexible design –
protein engineering, functional genomics
Fast turnaround –
Express Clonal Genes, rapid synthesis
Cost-effective –
affordable variants, scalable synthesis
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Simply add your details below and get quick access to the brochure.
Simply add your details below and get quick access to the brochure.
Simply add your details below and get quick access to the brochure.
